Search results for "MEL"
showing 10 items of 6009 documents
STUDY OF LIFE QUALITY AND TREATMENT SATISFACTION OF ROMANIAN DIABETIC PATIENTS
2019
In Romania, antidiabetic medication is free, based on a program of the Ministry of Public Health: “Treatment of patients with diabetes mellitus”. Since October 1, 2006, antidiabetic drugs have been delivered through open circuit pharmacies in contractual relationship with the National Health Insurance House, after four years of centralized delivery through hospital pharmacies.
 Objectives: This study aims to describe the influences of the diabetes treatment regarding patients’ quality of life and their satisfaction.
 Methods: A cross-sectional descriptive study was performed in pharmacies. The study includes 477 patients with diabetes mellitus from Cluj County, Romania. The interv…
New and classical methods to compare oxidative stress levels and parameters of vascular function in rat models of hypertension, diabetes and nitrate …
2020
Longitudinal investigation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in older patients in the province of Palermo (So…
2020
IntroductionClinical presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in old adults from Southern Italy is little known. This study aims to investigate the mortality risk related to risk factors, therapy and clinical course and to suggest prognostic indicators based on day-to-day follow-up of clinical and laboratory findings.Material and methodsIt was designed as a retrospective longitudinal cohort study of adult SARS-CoV-2 patients admitted at Partinico COVID Hospital in Palermo, Southern Italy. Patients were recruited between 4 March and 25 April and followed up until 31 May 2020, day-to-day until death or hospital discharge. Clinical data, laboratory…
CHANGES IN THE TEAR PROTEIN PATTERNS OF DIABETIC PATIENTS USING TWO-DIMENSIONAL ELECTROPHORESIS.
2000
Four to five million Germans suffer from diabetes mellitus, and worldwide there are about 100 million people that suffer with the disease. In diabetic patients, dry eye and other ocular surface diseases occur more often than in healthy subjects. Very little is known about the alterations in tears caused by diabetes mellitus, or its influence on the pathogenesis of e.g., the dry eye disease. Recent studies from our group showed that there are differences in the one-dimensional electrophoretic tear protein separations between diabetic patients and healthy volunteers.1,2 The aim of this study is to analyze the tear protein patterns of patients suffering from diabetes (DIA) (Fig.l), and to comp…
Changes in the Tear Protein Patterns of Diabetic Patients Using Two-Dimensional Electrophoresis
2002
Four to five million Germans suffer from diabetes mellitus, and worldwide there are about 100 million people that suffer with the disease. In diabetic patients, dry eye and other ocular surface diseases occur more often than in healthy subjects. Very little is known about the alterations in tears caused by diabetes mellitus, or its influence on the pathogenesis of e.g., the dry eye disease. Recent studies from our group showed that there are differences in the one-dimensional electrophoretic tear protein separations between diabetic patients and healthy volunteers.1,2 The aim of this study is to analyze the tear protein patterns of patients suffering from diabetes (DIA) (Fig.l), and to comp…
Influence of Metabolic Control on Thromboxane Biosynthesis and Plasma Plasminogen Activator Inhibitor Type-1 in Non-insulin-dependent Diabetes mellit…
1996
SummaryWe have previously shown that tight metabolic control by insulin therapy reduced thromboxane-dependent platelet activation in noninsulin-dependent diabetes mellitus (NIDDM) patients. The present study was undertaken to determine whether a similar effect could be obtained without switching diabetics in secondary failure to insulin treatment. For this purpose, we gave strict diet and exercise advise program and adjusted on a weekly basis the oral antidiabetic therapy (glipizide) that 26 patients with NIDDM had been given over the previous months.Basal measurements of urinary ll-dehydro-TXB2 and PAI-1 confirmed previous findings of enhanced levels of these parameters in NIDDM patients w…
2019
Background Endothelial dysfunction is a consequence of type 2 diabetes mellitus, but it is unclear whether endothelial dysfunction of conductance versus resistance vessels may also precede type 2 diabetes mellitus development. Methods and Results In a population‐based cohort of 15 010 individuals from the GHS (Gutenberg Health Study) (aged 35–74 years at enrollment in 2007–2012), we identified 1610 cases of incident pre–diabetes mellitus and 386 cases of incident type 2 diabetes mellitus by hemoglobin A 1c (HbA 1c ) and/or medical history between 2012 and 2017. Endothelial function of conductance and resistance vessels was measured by flow‐mediated dilation and digital volume plethysmograp…
Platelet Activity and Blood Lipid Changes in Diabetes Mellitus
1984
An altered platelet function can often be found in diabetes mellitus (2, 3, 4, 10, 13, 16, 17, 23, 24). Several studies have pointed towards an increased sensitivity of platelets to ADP induced aggregation (3, 6, 23) in diabetic patients; this phenomenon can also be found in diabetics without apparent vasculopathy and in subjects with altered glucose tolerance (3, 23).
Acute myocardial infarction occurring in versus out of the hospital: patient characteristics and clinical outcome
2000
OBJECTIVES We describe the baseline characteristics and clinical course of patients who had an acute myocardial infarction (AMI) during their hospital stay. BACKGROUND In comparison with patients who had an AMI outside of the hospital (prehospital AMI), the data on patients who had an AMI in the hospital are poorly described. METHODS Patients with an in-hospital AMI were prospectively registered in the Southwest German Maximal Individual TheRapy in Acute myocardial infarction (MITRA) study and compared with patients with prehospital AMI. RESULTS Of 5,888 patients with AMI, 403 patients (6.8%) had an in-hospital AMI. These patients were older, more often male and sicker as compared with the …
Environmental stressors and cardiovascular risk: Impact of environmental noise exposure on vascular oxidative stress and damage
2018
Epidemiological studies have demonstrated that traffic noise exposure is associated with cardiovascular diseases such as arterial hypertension, myocardial infarction and stroke. Persistent chronic noise exposure increases the risk of cardiovascular and metabolic diseases such as arterial hypertension, coronary artery disease, diabetes and stroke. Large epidemiological studies (reviewed in Munzel et al. Eur. Heart J. 2017, 38 (8):550–556) point towards a link between the incidence of ischemic heart diseases and exposure to noise, supporting its role as an independent cardiovascular risk factor. Recently, the underlying molecular mechanisms leading to noise-dependent adverse effects on the va…