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RESEARCH PRODUCT

Changes in the Tear Protein Patterns of Diabetic Patients Using Two-Dimensional Electrophoresis

Franz H. GrusPerihan SabuncuoAlbert J. AugustinSimone Herber

subject

medicine.medical_specialtybusiness.industryTear proteinsHealthy subjectsDiseasemedicine.diseaseeye diseasesPathogenesisTwo dimensional electrophoresisInternal medicineDiabetes mellitusmedicineTearssense organsbusinessOcular surface

description

Four to five million Germans suffer from diabetes mellitus, and worldwide there are about 100 million people that suffer with the disease. In diabetic patients, dry eye and other ocular surface diseases occur more often than in healthy subjects. Very little is known about the alterations in tears caused by diabetes mellitus, or its influence on the pathogenesis of e.g., the dry eye disease. Recent studies from our group showed that there are differences in the one-dimensional electrophoretic tear protein separations between diabetic patients and healthy volunteers.1,2 The aim of this study is to analyze the tear protein patterns of patients suffering from diabetes (DIA) (Fig.l), and to compare them to the patterns of healthy subjects (CTRL) using two-dimensional electrophoretic techniques.

yearjournalcountryeditionlanguage
2002-01-01
https://doi.org/10.1007/978-1-4615-0717-8_88