0000000000776914

AUTHOR

Simone Herber

showing 3 related works from this author

Two-dimensional analysis of tear protein patterns of diabetic patients

2001

In diabetic patients, dry eye and other ocular surface diseases occur more often than in healthy subjects. The aim of this study was to analyze the tear protein patterns of patients suffering from diabetes mellitus type II (dia) and to compare them to the patterns of healthy volunteers (ctrl). Tear proteins of nonstimulated tears of 20 patients (ctrl n=10, dia n=10) were separated using two-dimensional electrophoretic techniques. The protein patterns of each group were analyzed by a multivariate analysis of discriminance. Furthermore, for all spots of each gel, a 50 x 50 variables pH/Mr (molecular weight) array was generated and subsequently analyzed by a multivariate analysis of discrimina…

medicine.medical_specialtyMultivariate analysisbusiness.industryClinical BiochemistryTear proteinsSignificant differenceDiabetes mellitus type IIHealthy subjectsmedicine.diseaseBiochemistryAnalytical ChemistryOphthalmologyDiabetes mellitusHealthy volunteersMedicineTearsbusinessELECTROPHORESIS
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CHANGES IN THE TEAR PROTEIN PATTERNS OF DIABETIC PATIENTS USING TWO-DIMENSIONAL ELECTROPHORESIS.

2000

Four to five million Germans suffer from diabetes mellitus, and worldwide there are about 100 million people that suffer with the disease. In diabetic patients, dry eye and other ocular surface diseases occur more often than in healthy subjects. Very little is known about the alterations in tears caused by diabetes mellitus, or its influence on the pathogenesis of e.g., the dry eye disease. Recent studies from our group showed that there are differences in the one-dimensional electrophoretic tear protein separations between diabetic patients and healthy volunteers.1,2 The aim of this study is to analyze the tear protein patterns of patients suffering from diabetes (DIA) (Fig.l), and to comp…

medicine.medical_specialtybusiness.industryTear proteinsHealthy subjectsDiseasemedicine.diseaseeye diseasesPathogenesisOphthalmologyTwo dimensional electrophoresisOphthalmologyDiabetes mellitusMedicineTearssense organsbusinessOcular surfaceCornea
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Changes in the Tear Protein Patterns of Diabetic Patients Using Two-Dimensional Electrophoresis

2002

Four to five million Germans suffer from diabetes mellitus, and worldwide there are about 100 million people that suffer with the disease. In diabetic patients, dry eye and other ocular surface diseases occur more often than in healthy subjects. Very little is known about the alterations in tears caused by diabetes mellitus, or its influence on the pathogenesis of e.g., the dry eye disease. Recent studies from our group showed that there are differences in the one-dimensional electrophoretic tear protein separations between diabetic patients and healthy volunteers.1,2 The aim of this study is to analyze the tear protein patterns of patients suffering from diabetes (DIA) (Fig.l), and to comp…

medicine.medical_specialtybusiness.industryTear proteinsHealthy subjectsDiseasemedicine.diseaseeye diseasesPathogenesisTwo dimensional electrophoresisInternal medicineDiabetes mellitusmedicineTearssense organsbusinessOcular surface
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