0000000000505485
AUTHOR
Perihan Sabuncuo
showing 4 related works from this author
Analysis of Tear Protein Patterns for the Diagnosis of Dry Eye
2002
Dry eye syndrome occurs very frequently in the industrial world. In the United States, one of five people, 59 millions patients, suffer from symptoms of this disease (Eagle Vision, Yankelovich and Partners, 1997), and the number of patients has doubled in the last 10 years. 1-4 Diagnosis and treatment of dry eye syndrome are challenging. In fact, a curative therapy of this disease does not exist. Dry eye is a disease with various symptoms resulting from aqueous, mucin or lipid deficiency. Different diseases, among them Sjogren’s syndrome, can cause this deficiency, but most patients do not have accompanying disorders.
Two-dimensional analysis of tear protein patterns of diabetic patients
2001
In diabetic patients, dry eye and other ocular surface diseases occur more often than in healthy subjects. The aim of this study was to analyze the tear protein patterns of patients suffering from diabetes mellitus type II (dia) and to compare them to the patterns of healthy volunteers (ctrl). Tear proteins of nonstimulated tears of 20 patients (ctrl n=10, dia n=10) were separated using two-dimensional electrophoretic techniques. The protein patterns of each group were analyzed by a multivariate analysis of discriminance. Furthermore, for all spots of each gel, a 50 x 50 variables pH/Mr (molecular weight) array was generated and subsequently analyzed by a multivariate analysis of discrimina…
CHANGES IN THE TEAR PROTEIN PATTERNS OF DIABETIC PATIENTS USING TWO-DIMENSIONAL ELECTROPHORESIS.
2000
Four to five million Germans suffer from diabetes mellitus, and worldwide there are about 100 million people that suffer with the disease. In diabetic patients, dry eye and other ocular surface diseases occur more often than in healthy subjects. Very little is known about the alterations in tears caused by diabetes mellitus, or its influence on the pathogenesis of e.g., the dry eye disease. Recent studies from our group showed that there are differences in the one-dimensional electrophoretic tear protein separations between diabetic patients and healthy volunteers.1,2 The aim of this study is to analyze the tear protein patterns of patients suffering from diabetes (DIA) (Fig.l), and to comp…
Changes in the Tear Protein Patterns of Diabetic Patients Using Two-Dimensional Electrophoresis
2002
Four to five million Germans suffer from diabetes mellitus, and worldwide there are about 100 million people that suffer with the disease. In diabetic patients, dry eye and other ocular surface diseases occur more often than in healthy subjects. Very little is known about the alterations in tears caused by diabetes mellitus, or its influence on the pathogenesis of e.g., the dry eye disease. Recent studies from our group showed that there are differences in the one-dimensional electrophoretic tear protein separations between diabetic patients and healthy volunteers.1,2 The aim of this study is to analyze the tear protein patterns of patients suffering from diabetes (DIA) (Fig.l), and to comp…