Search results for "MEL"
showing 10 items of 6009 documents
Melanconia e immaginazione. Una genealogia fantastica per Melencolia I
2007
Il saggio indaga il concetto di melanconia nell'opera di R. Caillois Trois lecons des Ténèbres, tenendo conto della tradizione iconografica dureriana e della "scrittura" delle pietre. La mistica materiale suggerita dall'osservazione del mondo minerale permette a Caillois di assimilarsi alla natura delle pietre.
Continuous subcutaneous Insulin infusion leads to immediate, table, and long-term changes in metabolic control
2008
Background: Evaluations of continuous subcutaneous insulin infusion (CSII) usually focus on one pre- and one post-CSII measurement to assess metabolic therapy outcome. Aim: Extending this research, the aim of the present study was to provide a more fine-grained analysis of achieved glycaemic control. Methods: In 52 patients with type 1 diabetes (mean age of 37.85 years at CSII begin; s.d. ± 12.41), haemoglobin A1c (HbA1c) levels were assessed every 3 months over a period of 5 years (1 year before and 4 years after the introduction of CSII). Mixed models were utilized to describe changes in glycaemic control. Results: The pre–post course showed that already in the first quarter, a statis…
A Velocity Estimation Technique for a Monocular Camera Using mmWave FMCW Radars
2021
Perception in terms of object detection, classification, and dynamic estimation (position and velocity) are fundamental functionalities that autonomous agents (unmanned ground vehicles, unmanned aerial vehicles, or robots) have to navigate safely and autonomously. To date, various sensors have been used individually or in combination to achieve this goal. In this paper, we present a novel method for leveraging millimeter wave radar’s (mmW radar’s) ability to accurately measure position and velocity in order to improve and optimize velocity estimation using a monocular camera (using optical flow) and machine learning techniques. The proposed method eliminates ambiguity in optical flow veloci…
Response to comment on Properties and interactions – melting point of tribromobenzene isomers
2022
Melanomas klīniski morfoloģisks raksturojums
2018
Tēmas aktualitāte: Pēdējos gados saslimstība ar ādas melanomu pasaulē ir ievērojami palielinājusies, t.s. arī Latvijā, kur dzīvo pārsvarā gaišādainie cilvēki. Turklāt, onkoloģisko pacientu skaits, tajā skaitā arī melanomas pacientu mirstība pieaug. Mērķis: Raksturot melanomas histopatoloģiskos un klīniskus rādītājus nejauši izvēlētajā retrospektīvajā kohortā Rīgas Austrumu klīniskajā Universitātes slimnīcā. Pacienti un metodes: Retrospektīvs pētījums, kurā tika analizēti un apkopoti Patoloģijas centra arhīva histopatoloģiskie dati un klīniskie dati, izmantojot datu bāzi „ Ārstu birojs“. Pētījumā tika iekļauti pacienti, kuriem tika veikta ādas melanomas ķirurģiskā ārstēšana laika posmā no 20…
Análisis del la relación del genotipado y marcadores de estrés oxidativo con la presencia y grado de vasculopatía periférica en pacientes con diabete…
2014
RESUMEN: Padecer diabetes tipo 2 (DM2) ejerce un efecto independiente y multiplicador en la incidencia de complicaciones vasculares, añadido a la presencia de factores de riesgo clásicos. No todos los diabéticos desarrollan con la misma gravedad la vasculopatía periférica (VP). Este riesgo está presente en la fase de prediabetes, donde las complicaciones vasculares pueden preceder a la aparición de la propia diabetes. La biología vascular ha puesto de manifiesto la participación de otros factores como el estrés oxidativo (EO) y el estado crónico inflamatorio en el incremento de este riesgo. Los principales sistemas conocidos de EO a nivel endotelial generan especies reactivas de oxígeno. Pa…
Segmental resection for the excision of two multicystic ameloblastoma
2014
Objectives. The purpose of this study was addressed at the understanding and management in the ameloblastoma treatment, performing a segmental surgical resection. Ameloblastoma represents nearly 1% of all neoplasm located  Annali di Stomatologia 2014; Suppl. 3 to n. 2: 1-41 15 in the oral cavity. In 80% of cases it could be found in the mandible, of these lesions 70% are located in the molar re- gion or the ascending ramus, 20% in the premolar region and 10% in the anterior part. It is considered as a benign neoplasm with slow growing-pattern and locally aggressive behaviour. Methods. On the basis of clinicoradiological findings, ameloblastoma is divided into 3 groups: solid or multicyst…
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma
2011
International audience; So far, no common environmental and/or phenotypic factor has been associated with melanoma and renal cell carcinoma (RCC). The known risk factors for melanoma include sun exposure, pigmentation and nevus phenotypes; risk factors associated with RCC include smoking, obesity and hypertension. A recent study of coexisting melanoma and RCC in the same patients supports a genetic predisposition underlying the association between these two cancers. The microphthalmia-associated transcription factor (MITF) has been proposed to act as a melanoma oncogene; it also stimulates the transcription of hypoxia inducible factor (HIF1A), the pathway of which is targeted by kidney canc…
Availability of psychological care in pediatric diabetes centers – a real need?
2023
Rolę multidyscyplinarnego zespołu diabetologicznego w leczeniu osoby z cukrzycą podkreślają zarówno polskie, jak i międzynarodowe zalecenia. Znaczenie dostępności opieki psychologicznej dla samopoczucia i zdrowia psychicznego osób z cukrzycą (i ich opiekunów), a także dla wyników leczenia cukrzycy jest przedmiotem licznych analiz. Pomimo rekomendacji i badań pokazujących korzyści z interwencji i wsparcia psychologicznego, brakuje danych na temat rzeczywistej dostępności takiej opieki zarówno w Polsce, jak i na świecie.
Derepressing muscleblind expression by miRNA sponges ameliorates myotonic dystrophy-like phenotypes in Drosophila
2016
AbstractMyotonic Dystrophy type 1 (DM1) originates from alleles of the DMPK gene with hundreds of extra CTG repeats in the 3′ untranslated region (3′ UTR). CUG repeat RNAs accumulate in foci that sequester Muscleblind-like (MBNL) proteins away from their functional target transcripts. Endogenous upregulation of MBNL proteins is, thus, a potential therapeutic approach to DM1. Here we identify two miRNAs, dme-miR-277 and dme-miR-304, that differentially regulate muscleblind RNA isoforms in miRNA sensor constructs. We also show that their sequestration by sponge constructs derepresses endogenous muscleblind not only in a wild type background but also in a DM1 Drosophila model expressing non-co…