Search results for "MEMBER"
showing 10 items of 491 documents
In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic chang…
2011
Abstract Background P-glycoprotein (P-gp), an efflux transporter of the blood–brain barrier, limits the access of multiple xenobiotics to the central nervous system (CNS). Thus drug-dependent inhibition, induction or genetic variation of P-gp impacts drug therapy. Methods We investigated atypical antipsychotics and their interaction with P-gp. Amisulpride, clozapine, N-desmethylclozapine, olanzapine, and quetiapine were assessed in vitro on their inhibitory potential and in vivo on their disposition in mouse serum and brain, and behaviourally on the RotaRod test. In vivo wildtype (WT) and mdr1a/1b double knockout mice (mdr1a/1b (−/−, −/−); KO) were investigated. Results In rhodamine 123 eff…
Concensus Rorschach interaction patterns of families with an asthmatic child
1987
This paper reports a study of interaction in families with a child suffering from bronchial asthma. Eighteen families, subdivided into two groups according to the severity of the child's illness, were given the Consensus Rorschach following Willi's procedure. Quantitative assessments of family members on cognitive-affective functioning and social interaction were obtained. Factor analysis of quantitative scores revealed diversified interactional strategies among family member groups. Families as wholes varied as to patterns of cross-generational alliances and/or domination of different family members and could be clustered into four interactional pattern groups. There was no correlation bet…
DEVELOPMENT OF SMALL AND MEDIUM-SIZED ENTERPRISES IN REGIONS OF LATVIA
2021
For successful economic transition to the new stage of development improvements in business environment, as also the entrepreneurswho are ready to start your own business and to set up new companies. One of the main challenges the EU Member States face isthe need to boost their level of entrepreneurship and to become more competitive in the global market. That was one of the mainobjectives set by the Lisbon European Council, in March 2000, with a view to improving the Union’s performance in terms of employment,economic reform and social cohesion. Entrepreneurship is not only a driving force in the creation of new jobs, but it alsoincreases and enhances competitiveness and growth, personal f…
Competence Aspects of Responsible State Institutions
2014
One of the specific features of the law on IGOs relates to the fact that competence of state institutions of EU Member States for prosecution of the infringements of IGOs is envisaged within their jurisdictions. Therefore, in the case of IGOs, their infringements will be prosecuted both by right-holders of IGOs and state institutions of EU Member States. Considering these both prosecution possibilities, right-holders of IGOs have a choice either to prosecute infringements of IGOs themselves, i.e. bringing a case to a court if out-of-court settlement procedures were not successful or were not even chosen, or to apply to a state institution having competence to prosecute infringements of IGOs…
Interrelation Between European Union Protection and National Protection
2014
In addition to registration requirements, registration procedure, and the protection of registered IGOs, namely PDOs and PGIs, as well as protected indications of origin (within the Aromatised Wines Regulation), the EU law on IGOs also includes the regulation of other aspects. Competence of state institutions of EU Member States to ensure the observance of the regulation of IGOs as it is provided in the EU law or interrelation with other EU legal acts relating to IGOs already discussed in Part II of this book should be mentioned among such aspects.
A Machine Learning-Based Prediction Platform for P-Glycoprotein Modulators and Its Validation by Molecular Docking
2019
P-glycoprotein (P-gp) is an important determinant of multidrug resistance (MDR) because its overexpression is associated with increased efflux of various established chemotherapy drugs in many clinically resistant and refractory tumors. This leads to insufficient therapeutic targeting of tumor populations, representing a major drawback of cancer chemotherapy. Therefore, P-gp is a target for pharmacological inhibitors to overcome MDR. In the present study, we utilized machine learning strategies to establish a model for P-gp modulators to predict whether a given compound would behave as substrate or inhibitor of P-gp. Random forest feature selection algorithm-based leave-one-out random sampl…
Application of model quality evaluation to systems biology
2008
Application of model quality evaluation to the quasispecies models is presented. These models are useful for the analysis of the DNA and RNA evolution and for the description of the population dynamics of viruses and bacteria. An estimate of the parameters together with their interval of variability is computed and the quality evaluation is tested on the basis of the model prediction error capability.
Mediation and Private International Law: Improving Free Circulation of Mediation Agreements Across the EU
2016
This paper, commissioned by the European Parliament’s Policy Department for Citizens’ Rights and Constitutional Affairs upon request by the JURI Committee, examines the issues arising in the context of cross-border mediation. Cross-border litigation has increased steadily in recent years in Europe as a consequence of the consolidation of the European unification process. The enactment of Directive 2008/52/EC has certainly led to the presence of mediation legislation in the EU Member States. But many important differences can still be ascertained in relation to the legal framework developed, which affect key aspects of mediation. For mediation to obtain full endorsement by citizens in the fu…
The Migration Crisis: An Introduction
2020
In 2015, the EU and its member states struggled to coordinate, communicate, and cooperate on the migration crisis as the chapters in this section show. Schilde and Wallace Goodman point out that while border security contains examples of deeper integration, asylum management policy has followed the scenarios of breaking down and muddling through. All the authors highlight the Dublin convention as particularly ill-devised and thus paving the way for the refugee crisis. Bosilca finds evidence for breaking down in addition to minimal reforms of border security policy that constitute muddling through. Crawford argues that the migration crisis provides evidence both of muddling through and headi…
Implementing Cultural Diversity Within and Outside the European Union: A Test for the Delineation of Competences in Cultural Matters?
1970
The purpose of this paper is to evaluate the European Union’s (EU) involvement in the protection of cultural diversity, both within and outside the EU, after the entering into force of the Lisbon Treaty, in 2009, and the adoption of the UNESCO Convention of 2005. The author examines whether this involvement can be depicted in concrete measures aiming at the effective internal and external implementation of the provisions of the UNESCO Convention of 2005. The author further seeks to analyse whether the entailed consequences of EU’s actions, including the erosion of the Member State's competences in the cultural field, was translated in concrete measures or if it still remains at the politica…