Search results for "MEN1"

showing 3 items of 13 documents

Malignancy course of pituitary adenoma in MEN1 syndrome: Clinical-Neuroradiological signs

2020

Pituitary carcinomas (PCa) are extremely rare, indistinguishable from pituitary adenomas on histopathological grounds and have a poor prognosis. Most PCa start as PRL or ACTH secreting tumors in males, with relapsing invasive behaviour, refractoriness to medical and radiotherapy and increasing hormonal levels. The presence of distant metastases is still required for the diagnosis of PCa. The association with genetic endocrine diseases must be taken into account, since it adds further risk of evolution towards malignancy. Intradural spinal metastases have also been reported, so a complete craniospinal MR evaluation is recommended, when clinically indicated. We report a case of PCa, associate…

lcsh:Medical physics. Medical radiology. Nuclear medicinePathologymedicine.medical_specialtymedicine.medical_treatmentlcsh:R895-920Neoplasm metastasisTentorium cerebelliPituitary neoplasmPituitary neoplasmsMalignancyArticle030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicinePituitary adenomamedicineEndocrine systemRadiology Nuclear Medicine and imagingMEN1Ki-67 antigenNeoplasm metastasiPituitary carcinomabusiness.industryMagnetic resonance imaging MRISettore MED/37 - Neuroradiologiamedicine.diseasePituitary adenomaRadiation therapy030220 oncology & carcinogenesisPituitary neoplasms Pituitary carcinoma Pituitary adenoma Neoplasm metastasis Ki-67 antigen Magnetic resonance imaging MRIPituitary carcinomaSettore MED/36 - Diagnostica Per Immagini E RadioterapiabusinessEuropean Journal of Radiology Open
researchProduct

Lanreotide Therapy vs Active Surveillance in MEN1-Related Pancreatic Neuroendocrine Tumors2 Centimeters.

2019

Abstract Purpose Pancreatic neuroendocrine tumors (pNETs) are frequent in multiple endocrine neoplasia type 1 (MEN1) syndrome. They are usually not surgically treated unless larger than 1 to 2 cm or a growth rate > 0.5 cm per year. Somatostatin analogues represent one of the main therapeutic options in pNETs, but they have never been prospectively investigated in MEN1-related pNETs. The aim of this study was to prospectively evaluate the effectiveness of lanreotide in patients with MEN1-related pNETs < 2 cm. Methods MEN1 patients with 1 or more pNETs < 2 cm of maximal diameter were considered. Study design was prospective observational, comparing patients treated with l…

MaleEndocrinology Diabetes and MetabolismClinical BiochemistryNeuroendocrine tumorsLanreotideBiochemistryGastroenterologychemistry.chemical_compoundEndocrinologyactive surveillance lanreotide MEN1 pancreatic neuroendocrine tumors somatostatin analoguesProspective StudiesProspective cohort studyMultiple endocrine neoplasiasomatostatin analoguesMiddle AgedPrognosisTumor BurdenNeuroendocrine TumorsSomatostatinMEN1Disease ProgressionFemalelanreotideSomatostatinAdultmedicine.medical_specialtyAntineoplastic Agentspancreatic neuroendocrine tumorPeptides CyclicYoung AdultInternal medicinemedicineMultiple Endocrine Neoplasia Type 1HumansMEN1Watchful WaitingAgedCentimeterpancreatic neuroendocrine tumorsbusiness.industryBiochemistry (medical)active surveillancemedicine.diseasePancreatic NeoplasmsEndocrinologychemistryactive surveillance; lanreotide; MEN1; pancreatic neuroendocrine tumors; somatostatin analoguesTumor progressionCase-Control StudiesbusinessFollow-Up StudiesThe Journal of clinical endocrinology and metabolism
researchProduct

Breast-cancer predisposition in multiple endocrine neoplasia type 1

2014

Women with multiple endocrine neoplasia type 1 related to mutations in the gene encoding menin (MEN1) have approximately twice the risk of breast cancer as do women in the general population.

OncologyAdultRiskcongenital hereditary and neonatal diseases and abnormalitiesendocrine systemmedicine.medical_specialtyendocrine system diseasesGenotypePopulationVascular damage Radboud Institute for Health Sciences [Radboudumc 16]Breast Neoplasmsmedicine.disease_causeArticleBreast cancerSDG 3 - Good Health and Well-beingInternal medicineProto-Oncogene ProteinsGenotypemedicineCarcinomaMultiple Endocrine Neoplasia Type 1HumansMEN1Genetic Predisposition to DiseaseLongitudinal StudiesMultiple endocrine neoplasiaeducationGeneralLiterature_REFERENCE(e.g.dictionariesencyclopediasglossaries)GeneNetherlandsMutationeducation.field_of_studybusiness.industryCarcinoma Ductal BreastGeneral MedicineMiddle Agedmedicine.diseaseCarcinoma PapillaryImmunologyMutationFemalebusiness
researchProduct