Search results for "MFS"
showing 7 items of 7 documents
Efficacy of an internet-based psychological intervention for problem gambling and gambling disorder: study protocol for a randomized controlled trial
2021
Gambling Disorder is a prevalent non-substance use disorder, which contrasts with the low number of people requesting treatment. Information and Communication Technologies (ICT) could help to enhance the dissemination of evidence-based treatments and considerably reduce the costs. The current study seeks to assess the efficacy of an online psychological intervention for people suffering from gambling problems in Spain. The proposed study will be a two-arm, parallel-group, randomized controlled trial. A total of 134 participants (problem and pathological gamblers) will be randomly allocated to a waiting list control group (N = 67) or an intervention group (N = 67). The intervention program i…
A Meshfree Solver for the MEG Forward Problem
2015
Noninvasive estimation of brain activity via magnetoencephalography (MEG) involves an inverse problem whose solution requires an accurate and fast forward solver. To this end, we propose the Method of Fundamental Solutions (MFS) as a meshfree alternative to the Boundary Element Method (BEM). The solution of the MEG forward problem is obtained, via the Method of Particular Solutions (MPS), by numerically solving a boundary value problem for the electric scalar potential, derived from the quasi-stationary approximation of Maxwell’s equations. The magnetic field is then computed by the Biot-Savart law. Numerical experiments have been carried out in a realistic single-shell head geometry. The p…
The loss of the inducible Aspergillus carbonarius MFS transporter MfsA leads to ochratoxin A overproduction
2014
Ochratoxin A (OTA), a nephrotoxic compound produced by certain Aspergillus and Penicillium species, is one of the most abundant mycotoxins in food commodities. Aspergillus carbonarius is the main source of OTA in wine, grape juice and dried vine fruits. Although many studies have focused on OTA production by A. carbonarius, little is known about the genes related to OTA production and transport. We have found a transporter that belongs to the major facilitator superfamily (MfsA) which is highly expressed with a 102-fold induction in an ochratoxigenic A. carbonarius strain compared to a low OTA producer strain. The encoding mfsA gene shows similarity to the multidrug efflux transporter flu1 …
Some numerical modelings beyond the mesh
2015
In recent years meshless methods have gained much attention in several application areas of science. These methods benefit of savings due to the elimination of meshing process and are suite to handle changes in the geometry of the domain of interest. Further advantages come from the ease of implementation, which makes computer codes very flexible. We present some numerical experiences lying in the meshless framework dealing with domain and boundary-type methods.
Detection of the human brain activity with fundamental solution method
2018
Human brain activity mapping is a fundamental task for the neurophysiological research and for the diagnostic purposes too. Non-invasive techniques such as Electroencephalography (EEG) and magnetoencephalography (MEG) allow the reconstruction of the cerebral electrical currents providing useful information on the neuronal activity in the human brain. Based on a typical inverse problem the M/EEG imaging techniques require to solve more times a forward one. In this paper we discuss on a numerical tool based on the Method of the Fundamental Solutions(MFS) to efficiently solve the M/EEG forward problem going over the BEM state-of-the-art procedure. Inspired by the Leave-One-Out Cross Validation…
A meshfree approach for brain activity source modeling
2015
Weak electrical currents in the brain flow as a consequence of acquisition, processing and transmission of information by neurons, giving raise to electric and magnetic fields, which are representable by means of quasi-stationary approximation of the Maxwell’s equations. Measurements of electric scalar potential differences at the scalp and magnetic fields near the head constitute the input data for, respectively, electroencephalography (EEG) and magnetoencepharography (MEG), which allow for reconstructing the cerebral electrical currents and thus investigating the neuronal activity in the human brain in a non-invasive way. This is a typical erectromagnetic inverse problem, since measuremen…
Designing Dynamic Sustainable Business Models to Assess the Feasibility of an Industrial Symbiosis: The Case of the Retro-Port Area of Trieste
2023
This study evaluates the managerial sustainability of implementing a decision support system for industrial symbiosis through a recent business modeling methodology. The decision support system is intended to facilitate the identification of implementable industrial symbiosis good practices in a pilot project located in the industrial retro-port area of Trieste. To evaluate the feasibility of this project, a qualitative “Dynamic business model canvas for sustainability” was designed and supported by a system dynamics approach using causal loop diagrams. The study analyzed various governance scenarios for managing the decision support system (public, private, or public–private partnership) a…