Search results for "MICE"
showing 10 items of 6027 documents
Small airways in sedentary and endurance-trained dystrophic (mdx) mice.
2015
The effects of mild endurance exercise training on the small airways in mdx mice are unknown. We compared epithelial thickness and turnover, apoptosis, and stress marker expression in small airways of mdx mice and wild-type (WT) controls, at rest and during exercise training. Mdx and WT mice were randomly assigned to sedentary (mdx-S, n=17; WT-S, n=19) or trained (mdx- EX, n=14; WT-EX, n=16) groups. Low-intensity endurance training (running on a wheel) was done 5 d/wk for 6 wk at progressively increasing speed (rpm from 16 to 24) and time (15 min to 1 h). Lungs were processed for light microscopy and periodic acid Schiff (PAS) staining. Hsp60 and PCNA were quantified by immunohistochemistry…
Ocular Drug Delivery Systems per la veicolazione di molecole bioattive al segmento posteriore dell'occhio
Development of stimulus-sensitive electrospun membranes based on novel biodegradable segmented polyurethane as triggered delivery system for doxorubi…
2022
In this work, redox-sensitive polyurethane urea (PUU) based electrospun membranes have been exploited to chemically tether a pH-sensitive doxorubicin derivative achieved by linking a lipoyl hydrazide to the drug via a hydrazone linkage. First, the lipoyl-hydrazone-doxorubicin derivative labelled as LA-Hy-Doxo has been syn- thesized and characterized. Then, the molecule has been tethered, via a thiol-disulfide exchange reaction, to the redox-sensitive PUU (PolyCEGS) electrospun membrane. The redox-sensitive PolyCEGS PUU has been produced by using PCL-PEG-PCL polyol and glutathione-tetramethyl ester (GSSG-OMe)4 as a chain extender. The LA-Hy- Doxo tethered electrospun membrane has showed a du…
Inulin derivatives obtained via enhanced microwave synthesis as potential drug delivery system.
2013
PRODUCTION OF MICELLES FROM HYALURONIC ACID AMPHIPHILIC DERIVATIVES FOR TARGETED RELEASE OF DOXORUBICIN
2010
NOVEL AMPHIPHILIC COPOLYMERS BASED ON POLYASPARTAMIDE GRAFT WITH SQUALENE RESIDUES TO OBTAIN MICELLES AS COLLOIDAL DRUG CARRIERS.
2009
POLYMERIC MICELLES AS TUNABLE OFF-ON-OFF pH WINDOW BIOSENSORS.
2009
POLYMERIC MICELLES BASED ON A PHOSPHOLIPID/ POLYASPARTAMIDIC COPOLYMER FOR BECLOMETHASONE DIPROPIONATE DELIVERY TO THE LUNGS
2010
POLYMERIC MICELLES FOR DRUG TARGETING TO THE BRAIN
2008
The use and beauty of ultra-high-resolution seismic reflection imaging in Late Quaternary marine volcaniclastic settings, Napoli Bay, Italy
2019
A Nápolyi-öbölben felvett ultra nagy felbontású egycsatornás (IKB-Seistec™) reflexiós szeizmikus szelvények korábbi geológiai és geofizikai vizsgálatok eredményeivel együtt kivételes, eddig soha nem látott felbontású szeizmikus leképezését nyújtják a Flegrei-mezők és a Somma-Vezúv felszín alá süllyedt késő-pleisztocén–holocén rétegtani felépí - tésének. A szeizmikus szelvényeken látott geometria és gravitációs magvevővel nyert üledékek adatainak összevetéséből Campania partközeli kontinentális talapzatán számos olyan üledékes és vulkáni szerkezet, valamint hidrotermális jelenség került leképezésre, melyek a legutolsó glaciális maximum (kb. 18 000 év) óta keletkeztek. A Pozzuoli-öbölben mért…