Search results for "MIF"
showing 10 items of 246 documents
5' and 3' RACE Method to Obtain Full-Length 5' and 3' Ends of Ciona robusta Macrophage Migration Inhibitory Factors Mif1 and Mif2 cDNA
2019
The 5' and 3' RACE is a method to obtain full-length 5' and 3' ends of cDNA using known cDNA sequences from expressed sequence tags (ESTs), subtracted cDNA, differential display, or library screening. Here is described the identification of full-length 5' and 3' ends of Ciona robusta Mif1 and Mif2 cDNA by using 5' and 3' RACE method.
Radioprotection and Radiomitigation: From the Bench to Clinical Practice.
2020
The development of protective agents against harmful radiations has been a subject of investigation for decades. However, effective (ideal) radioprotectors and radiomitigators remain an unsolved problem. Because ionizing radiation-induced cellular damage is primarily attributed to free radicals, radical scavengers are promising as potential radioprotectors. Early development of such agents focused on thiol synthetic compounds, e.g., amifostine (2-(3-aminopropylamino) ethylsulfanylphosphonic acid), approved as a radioprotector by the Food and Drug Administration (FDA, USA) but for limited clinical indications and not for nonclinical uses. To date, no new chemical entity has been approved by …
Gamificación en la docència de lingüística clínica : un Cluedo per als trastorns del llenguatge
2018
La experiencia que presentamos en este articulo surge como respuesta a la dificultad manifestada por el alumnado en la asignatura Intervencion de los Trastornos del Aprendizaje, de la Comunicacion y del Lenguaje y de la Conducta en el Grado de Educacion Infantil de la Universidad Internacional de Valencia, para la aplicacion de los conocimientos teoricos a la practica. Para que el alumnado mejore la competencia en el saber, saber hacer y ser y aplique de forma eficaz los conocimientos adquiridos sobre los trastornos se ha disenado una propuesta con dos objetivos: 1: afianzar los aprendizajes conceptuales sobre las caracteristicas que componen los trastornos, y 2: aplicar los conocimientos s…
La gamificación como estrategia metodológica para la inclusión en Educación Primaria
2020
Una de las necesidades fundamentales de la educación actual es proporcionar un aprendizaje inclusivo y adaptado al alumnado que presenta Necesidades Específicas de Apoyo Educativo (NEAE). En este propósito, ocupa un papel muy importante la estrategia metodológica que se emplea en el proceso de enseñanza y aprendizaje. Ya que cada vez son más notables las carencias de modelos educativos que buscan enseñar los mismos contenidos, de la misma manera, pero a alumnado muy diverso. Por este motivo, en esta investigación se va analizar una estrategia metodológica relativamente novedosa, la gamificación, que se define como el uso de mecánicas, estéticas y elementos propios del diseño de juegos con e…
Côté mauvaises herbes, tir de barrage sur trois envahissantes
2006
National audience; Les plantes envahissantes sont évoquées à la conférence sur les zones non agricoles de l'AFPPà Avignon les 11 et 12octobre 2006. La situation à leur égard en France et en Europe est présentée, notamment les dispositions réglementaires et l'identité des 34 principales espèces. Deux communications traitent de l'ambroisie à feuille d'armoise Ambrosia artemisiifolia. Un point sur les méthodes de lutte mécanique, chimique, etc.) insiste sur l'intérêt de la prévention (enherbement, etc.)et de la concertation entre acteurs agricoles et non agricoles. Des essais de lutte chimique (glyphosate ou glufosinate-ammonium en 2004 et 2005, les montrent équivalents et intéressants en débu…
Data from: Assessing metabolic constraints on the maximum body size of actinopterygians: locomotion energetics of Leedsichthys problematicus (Actinop…
2019
Maximum sizes attained by living actinopterygians are much smaller than those reached by chondrichthyans. Several factors, including the high metabolic requirements of bony fishes, have been proposed as possible body-size constraints but no empirical approaches exist. Remarkably, fossil evidence has rarely been considered despite some extinct actinopterygians reaching sizes comparable to those of the largest living sharks. Here, we have assessed the locomotion energetics of Leedsichthys problematicus, an extinct gigantic suspension-feeder and the largest actinopterygian ever known, shedding light on the metabolic limits of body size in actinopterygians and the possible underlying factors th…
The effect of amifostine or IMRT to preserve the parotid function after radiotherapy of the head and neck region measured by quantitative salivary gl…
2008
Purpose: In this retrospective study, two approaches to preserve the parotid function after radiotherapy (RT) were compared: application of the radioprotective agent amifostine during RT and parotid sparing intensity-modulated radiotherapy (IMRT). Patients and methods: Patients were qualified for this analysis if (1) both parotid glands received a radiation dose of P50 Gy using conventional radiotherapy techniques (cRT) or if they received a parotid sparing IMRT as alternative, if (2) salivary gland scintigraphies before and after RT were performed, and if (3) a normal parotid function was present before RT. Quantitative salivary gland scintigraphy was used to assess the parotid gland funct…
The Endogenous Opioid System Is Not Involved in Modulation of Opioid-Induced Hyperalgesia
2009
Abstract Some recent studies suggested a role of the endogenous opioid system in modulating opioid-induced hyperalgesia (OIH). In order to test this hypothesis, we conducted a prospective randomized, placebo-controlled, 2-way crossover study in healthy human volunteers. We utilized a well-established model of inducing OIH after a brief exposure to the μ-opioid agonist remifentanil using intradermal electrical stimulation. Patients were exposed to a randomized 90-minute infusion of remifentanil or saline placebo during 2 separate occasions. Development of OIH was quantified using changes in the average radius of the area of secondary hyperalgesia generated by electrical pain stimulation. A 2…
Protective effect of amifostine on dental health after radiotherapy of the head and neck.
2000
Abstract Purpose: The cytoprotective agent amifostine has been shown to reduce the radiation-induced acute and chronic xerostomia in head and neck cancer patients. The purpose of this study was to evaluate whether or not amifostine also reduces the incidence of dental caries associated with the radiation-induced xerostomia. Methods and Materials: The dental status before and 1 year after radiotherapy was retrospectively compared in 35 unselected patients treated as part of the prospective randomized and multicenter open-label Phase III study (WR-38) at the University Hospitals of Heidelberg, Freiburg, and Erlangen. The WR-38 study compared radiotherapy in head and neck cancer with and witho…
Human cerebral microcirculation and oxygen saturation during propofol-induced reduction of bispectral index †
2011
† This study investigates the effects of propofol-induced changes in bispectral index (BIS) on cerebral microcirculation and oxygenation during craniotomies. † In 2 mm cerebral depth, an increase in propofol dosage resulted in increased oxygen saturation (srvO2 )w ithout reduction of capillary venous blood flow (rvCBF). † Difference in oxygen content (avDO2) and approximated cerebralmetabolicrateofoxygen (aCMRO2) decreased with an increase in propofol dosage in 2 mm cerebral depth. † Alterations in BIS showed no effect on rvCBF, srvO2 ,a nd haemoglobin amount (rvHb) or on avDO2 or aCMRO2 in 8 mm cerebral depth. † These findings suggest that the CBF/CMRO2 ratio is altered by propofol in a re…