Search results for "MIME"
showing 10 items of 311 documents
Fabrication of elastomeric scaffolds with curvilinear fibrous structures for heart valve leaflet engineering
2014
Native semi-lunar heart valves are composed of a dense fibrous network that generally follows a curvilinear path along the width of the leaflet. Recent models of engineered valve leaflets have predicted that such curvilinear fiber orientations would homogenize the strain field and reduce stress concentrations at the commissure. In the present work, a method was developed to reproduce this curvilinear fiber alignment in electrospun scaffolds by varying the geometry of the collecting mandrel. Elastomeric poly(ester urethane)urea was electrospun onto rotating conical mandrels of varying angles to produce fibrous scaffolds where the angle of fiber alignment varied linearly over scaffold length.…
Clinical and molecular data in cases of prenatal localized overgrowth disorder: major implication of genetic variants in PI3K‐AKT‐mTOR signaling path…
2021
To describe clinical and molecular findings in a French multicenter cohort of fetuses with prenatal diagnosis of congenital abnormality and suspicion of a localized overgrowth disorder (LOD) suggestive of genetic variants in the PI3K-AKT-mTOR signaling pathway.We analyzed retrospectively data obtained between 1 January 2013 and 1 May 2020 from fetuses with brain and/or limb overgrowth referred for molecular diagnosis of PI3K-AKT-mTOR pathway genes by next-generation sequencing (NGS) using pathological tissue obtained by fetal autopsy. We also assessed the diagnostic yield of amniotic fluid.During the study period, 21 subjects with LOD suspected of being secondary to a genetic variant of the…
2019
Despite substantial advances in many different fields of neurorobotics in general, and biomimetic robots in particular, a key challenge is the integration of concepts: to collate and combine research on disparate and conceptually disjunct research areas in the neurosciences and engineering sciences. We claim that the development of suitable robotic integration platforms is of particular relevance to make such integration of concepts work in practice. Here, we provide an example for a hexapod robotic integration platform for autonomous locomotion. In a sequence of six focus sections dealing with aspects of intelligent, embodied motor control in insects and multipedal robots-ranging from comp…
Auditory Phenomena and Human Life: Phenomenological Experience
2018
The present study analyzes auditory phenomena from the point of view of hermeneutical phenomenology and shows their interconnectedness with the understanding of man, hearing and listening within the context of human life as the horizon of meaningful sonority and silence. The central questions to be answered in this study are these: What is experienced as sound and sonority? How does a human see himself in inclusion of his being from where he listens, understands, and speaks? The study explores the classical standpoints of Husserl’s phenomenology and other philosophical apprehensions which confirm that auditory phenomena is not to be apprehended solely as an isolated horizon but as being per…
Nuorten identiteetti-ilmaisu IRC-Galleriassa : ilmaisukeinoina nimimerkit, profiilikuvat ja kuvatekstit
2010
NUORTEN IDENTITEETTI-ILMAISU IRC-GALLERIASSA Ilmaisukeinoina nimimerkit, profiilikuvat ja kuvatekstit Piia Pyykkönen Sosiologia Pro gradu-tutkielma Yhteiskuntatieteiden ja filosofian laitos Jyväskylän yliopisto Ohjaaja: Terhi-Anna Wilska Syksy 2010 Sivumäärä: 113 Pro gradu-tutkielmani käsittelee nuorten identiteetti-ilmaisua IRC-Galleriassa. Identiteettiilmaisun selvittämisessä ovat apuna nuorten profiilikuvat, niihin liittyvät tekstit sekä nuorten itselleen keksimät nimimerkit. Aineisto on kerätty internetin sosiaalisesta yhteisöpalvelusta IRC-Galleriasta. Aineisto koostuu neljässä eri yhteisössä olevien jäsenten profiilikuvista, niihin liittyvistä kuvateksteistä ja jäsenten nimimerkeistä.…
Forchlorfenuron-mimicking haptens: From immunogen design to antibody characterization by hierarchical clustering analysis
2011
To obtain highly-specific and selective forchlorfenuron binders, a collection of functionalized derivatives with different spacer arm locations and lengths was prepared. By immunization with target-mimicking haptens, a large battery of monoclonal and polyclonal antibodies against this synthetic cell regulator was produced and exhaustively characterized in two immunoassay formats using homologous and heterologous conjugates. Antibodies with IC50 values lower than 0.3 nM were successfully raised from the prepared immunogens, thus evidencing the efficacy of the explored strategies. In order to identify significant epitopes in the antibody-antigen interaction, a series of new chemical forchlorf…
Arginine-Rich Peptidomimetic Ampicillin/Gentamicin Conjugate To Tackle Nosocomial Biofilms: A Promising Strategy To Repurpose First-Line Antibiotics
2023
: Combined therapy with penicillins and aminoglycosides has been proved beneficial to address many persistent bacterial infections with possible synergistic effects. However, the different pharmacokinetic profiles of these two antibiotic classes may not guarantee a concerted spatio-temporal delivery at the site of action, decreasing the efficacy of this combination and promoting resistance. Herein, we propose a multifunctional antibiotic-polymer conjugate, designed to colocalize ampicillin and gentamicin to tackle persistent biofilm infections. The two antibacterial molecules were grafted along with the amino acid l-arginine to a biocompatible polymer backbone with peptidomimetic hydrophili…
Biomimetic Alginate/Gelatin Cross-Linked Hydrogels Supplemented with Polyphosphate for Wound Healing Applications
2020
In the present study, the fabrication of a biomimetic wound dressing that mimics the extracellular matrix, consisting of a hydrogel matrix composed of non-oxidized and periodate-oxidized marine alginate, was prepared to which gelatin was bound via Schiff base formation. Into this alginate/oxidized-alginate-gelatin hydrogel, polyP was stably but reversibly integrated by ionic cross-linking with Zn2+ ions. Thereby, a soft hybrid material is obtained, consisting of a more rigid alginate scaffold and porous structures formed by the oxidized-alginate-gelatin hydrogel with ionically cross-linked polyP. Two forms of the Zn-polyP-containing matrices were obtained based on the property of polyP to f…
Challenge of tacit knowledge in acquiring information in cognitive mimetics
2019
Intelligent technologies are rising. This is why methods for designing them are important. One approach is to study how people process information in carrying out intelligence demanding tasks and use this information in designing new technology solutions. This approach can be called cognitive mimetics. A problem in mimetics is to explicate tacit or subconscious knowledge. Here, we study a combination of thinking aloud in ship simulator driving and focus group commenting the solutions of subjects. On the ground of these early experiments, a multiple method combination seems to be the best way forward to solve problems of tacit or subconscious knowledge. peerReviewed