Search results for "MITO"
showing 10 items of 2513 documents
Bioactivity of fractions and constituents of Piper capense fruits towards a broad panel of cancer cells.
2020
Abstract Ethnopharmacological relevance Piper capense is a medicinal spice whose fruits are traditionally used as aqueous decoction to heal several ailments such as trypanosomiasis, helminthic infections, and cancer. Aim of the study. (1) To perform phytochemical investigation of the methanol extract of Piper capense; (2) to evaluate the cytotoxicity of botanicals (PCF, fractions PCFa-e), isolated phytochemicals on a broad panel of animal and human cancer cell lines; (3) to evaluate the induction of apoptosis of the most active samples. Material and methods Resazurin reduction assay (RRA) was used to determine the cytotoxicity of the studied samples. Cell cycle distribution (PI staining), a…
Un discípulo valenciano de Vicente López en Madrid: Antonio Gómez Cros
1992
LA IMAGEN DE LOS SEGUIDORES DE LOS GRANDES PINTORES ES SIEMPRE ECLIPSADA POR EL BRILLO DE LOS MAESTROS, ES EL CASO DEL PINTOR VALENCIANO ANTONIO GOMEZ CROS, DISCIPULO DE VICENTE LOPEZ Y PORTAÑA, QUE SE DESPLAZO A MADRID A ESTUDIAR Y A TRABAJAR AL LADO DE LOPEZ. SU PINTURA Y SU BIOGRAFIA ES, HASTA LA ACTUALIDAD, BASTANTE DESCONOCIDA. ESTE ARTICULO DESARROLLA ESTOS Y OTROS ASPECTOS EN UN INTENTO DE CLARIFICAR SU PERSONALIDAD COMO ARTISTA.
Return flight to the Canary Islands – The key role of peripheral populations of Afrocanarian blue tits (Aves: Cyanistes teneriffae) in multi-gene rec…
2012
Abstract Afrocanarian blue tits (Cyanistes teneriffae) have a scattered distribution on the Canary Islands and on the North African continent. To date, the Canary Islands have been considered the species’ main Pleistocene evolutionary center, but their colonization pathways remain uncertain. We set out to reconstruct a dated multi-gene phylogeny and ancestral ranges for Cyanistes tit species including the currently unstudied, peripheral Libyan population of C. t. cyrenaicae. In all reconstructions the most easterly and westerly peripheral populations (in Libya and on La Palma) represented basal offshoots of C. teneriffae. These two peripheral populations shared all four major indels and dif…
Mitochondrial dysfunction and host immune response during pneumococcal pneumonia : impact of mechanical ventilation?
2020
Lung damage induced by mechanical ventilation (MV) worsens the prognosis of pneumonia. Mitochondrial dysfunctions could account for such deleterious effects. Accordingly, data obtained from both in vitro and in vivo experimental studies, as well as in ventilated patients with acute respiratory distress syndrome, show that mitochondrial alarmins, especially mitochondrial DNA, are released in the alveolar compartment as a result of the cyclic stretch, and could thus represent one link between the mechanical insult and the sterile inflammation leading to VILI (ventilator-induced lung injury). In rabbits, we show herein that adverse and prolonged MV worsens the prognosis of pneumococcal pneumon…
Navigando destini. La geografia umana di Elio Pecora
2017
Studio monografico sul poeta, narratore, drammaturgo Elio Pecora, con bibliografia aggiornata
Compagno di strada
2012
Introduzione alla figura e all'opera del primo Premio Nobel per la Letteratura africano, Wole Soyinka, autore prolifico e attivista nigeriano, e alla sua ricezione in Italia
Proyección y reivindicación de los poetas yahilíes en la poesía árabe contemporánea.
2001
Veglison Elias de Molins, Josefina - Josefina.Veglison@uv.es Este articulo analiza las referencias a poetas de la Yahiliyya presentes en la poesía árabe contemporánea en calidad de mitos y arquetipos. Cabe destacar el hecho de que éstos sean beduinos pertenecientes a la categoría de autores de mu'allaqa o al grupo de poetas bandoleros (sa'álik). El autor contemporáneo rescata sus figuras porque interpreta como signo de modernidad su talante innovador y su rebeldía contra la norma, tanto en lo formal como en los contenidos. Esta reivindicación se lleva a cabo, en los contenidos, mediante la evocación de sus nombres en poemas o títulos de diwanes, la inclusión de sus versos o la réplica a sus…
Amorphous Ca2+ polyphosphate nanoparticles regulate the ATP level in bone-like SaOS-2 cells
2015
ABSTRACT Polyphosphate (polyP) is a physiologically occurring polyanion that is synthesized especially in bone-forming osteoblast cells and blood platelets. We used amorphous polyP nanoparticles, complexed with Ca2+, that have a globular size of ∼100 nm. Because polyP comprises inorganic orthophosphate units that are linked together through high-energy phosphoanhydride bonds, we questioned whether the observed morphogenetic effect, elicited by polyP, is correlated with the energy-generating machinery within the cells. We show that exposure of SaOS-2 osteoblast-like cells to polyP results in a strong accumulation of mitochondria and a parallel translocation of the polyP-degrading enzyme alka…
“Mitotic Slippage” and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres
2020
Mitotic slippage (MS), the incomplete mitosis that results in a doubled genome in interphase, is a typical response of TP53-mutant tumors resistant to genotoxic therapy. These polyploidized cells display premature senescence and sort the damaged DNA into the cytoplasm. In this study, we explored MS in the MDA-MB-231 cell line treated with doxorubicin (DOX). We found selective release into the cytoplasm of telomere fragments enriched in telomerase reverse transcriptase (hTERT), telomere capping protein TRF2, and DNA double-strand breaks marked by γH2AX, in association with ubiquitin-binding protein SQSTM1/p62. This occurs along with the alternative lengthening of telomeres (ALT) and DNA repa…
Cracking the nut: Geographical adjacency of sister taxa supports vicariance in a polytomic salamander clade in the absence of node support
2008
The urodelan genus Lyciasalamandra, which inhabits a relatively small area along the southern Turkish coast and some Aegean islands, provides an outstanding example of a diverse but phylogenetically unresolved taxon. Molecular trees contain a single basal polytomy that could be either soft or hard. We here use the information of nuclear (allozymes) and mitochondrial (fractions of the 16S rRNA and ATPase genes) datasets in combination with area relationships of lineages to resolve the phylogenetic relationships among Lyciasalamandra species in the absence of sufficient node support. We can show that neither random processes nor introgressive hybridization can be invoked to explain that the m…