Search results for "ML"
showing 10 items of 1465 documents
No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Data…
2021
Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers of pathogenic changes in mismatch repair (MMR) genes have an increased risk of developing colorectal (CRC), endometrial, ovarian, urinary tract, prostate, and other cancers, depending on which gene is malfunctioning. In Lynch syndrome, differences in cancer incidence (penetrance) according to the gene involved have led to the stratification of cancer surveillance. By contrast, any differences in penetrance determined by the type of pathogenic variant remain unknown. Objective. To determine cumulative incidences of cancer in carriers of truncating and missense or aberrant splicing pathogenic …
Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mous…
2013
The t(8;21) chromosomal translocation activates aberrant expression of the AML1-ETO (AE) fusion protein and is commonly associated with core binding factor acute myeloid leukaemia (CBF AML). Combining a conditional mouse model that closely resembles the slow evolution and the mosaic AE expression pattern of human t(8;21) CBF AML with global transcriptome sequencing, we find that disease progression was characterized by two principal pathogenic mechanisms. Initially, AE expression modified the lineage potential of haematopoietic stem cells (HSCs), resulting in the selective expansion of the myeloid compartment at the expense of normal erythro- and lymphopoiesis. This lineage skewing was foll…
Teksta iegūšana no HTML5 canvas elementiem
2016
HTML5 canvas elements un visa tajā atveidotā informācija pēc būtības ir attēls, līdz ar to, no lietojamības viedokļa, grūti pieejams lietotājiem, it īpaši redzes invalīdiem, kuri paļaujas uz ekrāna lasīšanas programmatūru. Darbā pētītas vairākas dažādas metodes HTML5 canvas elementos zīmētās teksta informācijas iegūšanai no lietotāja puses, ļaujot tekstu iezīmēt, kopēt un padarot to pieejamu ekrāna lasīšanas programmatūrai, tādējādi uzlabojot tīmekļa vides lietojamību, it īpaši cilvēkiem ar redzes problēmām. Darba rezultātā veiksmīgi izveidots JavaScript spraudnis, kuru tīmekļa lietotņu izstrādātāji var izmantot, lai bez piepūles zīmētu iezīmējamu, kopējamu un ekrāna lasītājiem pieejamu tek…
Unit 3: the capital asset pricing model (capm). parte teórica
2022
La unidad se basa en cml, cml y el modelo capm.
Unit 3: the capital asset pricing model (capm). parte práctica
2022
actividades relacionadas con la cml, sml y capm
New insights for materials science characterisation using different complementary techniques combined with X-ray absorption Spectroscopy
2005
The combination of x-ray absorption spectroscopy (XAS) with UV-Vis and Raman spectroscopies or with Differential Scanning Calorimetry (DSC) has been recently carried out on the D44 beamline of DCI-LURE. The different set-ups used to perform such combinations are described and examples of combined investigations belonging to different field of materials science (coordination chemistry, sol-gel and catalysis) are presented.
Fiberless, Multi-Channel fNIRS-EEG System Based on Silicon Photomultipliers: Towards Sensitive and Ecological Mapping of Brain Activity and Neurovasc…
2020
Portable neuroimaging technologies can be employed for long-term monitoring of neurophysiological and neuropathological states. Functional Near-Infrared Spectroscopy (fNIRS) and Electroencephalography (EEG) are highly suited for such a purpose. Their multimodal integration allows the evaluation of hemodynamic and electrical brain activity together with neurovascular coupling. An innovative fNIRS-EEG system is here presented. The system integrated a novel continuous-wave fNIRS component and a modified commercial EEG device. fNIRS probing relied on fiberless technology based on light emitting diodes and silicon photomultipliers (SiPMs). SiPMs are sensitive semiconductor detectors, whose large…
Java-COM integration with JACOB using XML wrappers
2006
Many Windows-based legacy applications can be programmatically accessed using COM interfaces. However, calling COM components from Java is not straightforward. This report compares four open source Java-COM integration packages. A technique for typesafe Java-COM integration is presented. The technique is based on typesafe COM interface wrappers using jcom, java2com and JACOB libraries. Examples with Microsoft Office applications are presented. XML wrapper and code generator can be bundled with future JACOB releases as an alternative to Jacobgen wrapper generator. nonPeerReviewed
Spatialization of the Semantic Web
2012
syntax for Horn-like rules. The SWRL as the form, antecedentconsequent, where both antecedent and consequent are conjunctions of atoms written a1^ ... ^ an. Atoms in rules can be of the form C(x), P(x,y), Q(x,z), sameAs(x,y), differentFrom(x,y), or builtIn(pred, z1, ..., zn), where C is an OWL description, P is an OWL individual-valued property, Q is an OWL data-valued property, pred is a datatype predicate URIref, x and y are either individual-valued variables or OWL individuals, and z, z1, ... zn are either data-valued variables or OWL data literals. An OWL data literal is either a typed literal or a plain literal. Variables are indicated by using the standard convention of prefixing the…
In the literature: April 2020
2020
Deficient DNA mismatch repair (dMMR) may be caused by germline or somatic mutations in mismatch repair genes ( MLH1 , MSH2 , MSH3 , MSH6 and PMS2 ) or through epigenetic silencing of MLH1 .1 dMMR induces a hypermutator phenotype, also known as microsatellite instability (MSI). Next-generation sequencing identifies MSI in 12 cancer types. The highest prevalence is seen in endometrial cancer (31.4%), followed by colorectal cancer (19.7%) and gastric cancer (GC, 19.1%). MSI was related to better prognosis for colorectal cancer and GC . Moreover, the dMMR/MSI hypermutator phenotype is thought to produce large numbers of immunogenic neoantigens that can be recognised by immune cells, leading to …