6533b833fe1ef96bd129c3b7

RESEARCH PRODUCT

Fiberless, Multi-Channel fNIRS-EEG System Based on Silicon Photomultipliers: Towards Sensitive and Ecological Mapping of Brain Activity and Neurovascular Coupling

Giuseppe GrecoLeonardo MistrettaGiuseppe Costantino GiaconiaRupert OrtnerFilippo ZappasodiGünter EdlingerPier Giorgio FallicaDavid PerpetuiniPierpaolo CroceArcangelo MerlaMario Francesco RomeoVincenzo VinciguerraAntonio Maria ChiarelliRaimondo Rizzo

subject

clinical brain monitoringBrain activity and meditationComputer scienceneurovascular couplingElectroencephalographylcsh:Chemical technologySettore ING-INF/01 - Elettronica01 natural sciencesBiochemistryArticleAnalytical Chemistry010309 optics03 medical and health sciences0302 clinical medicineSilicon photomultiplierNeuroimagingInterference (communication)Component (UML)0103 physical sciencesmedicineHumanslcsh:TP1-1185electroencephalography (EEG)Electrical and Electronic EngineeringSpectroscopyInstrumentationBrain MappingSpectroscopy Near-Infraredmedicine.diagnostic_testEcologyHemodynamicsmultimodal neuroimagingBrainMultimodal neuroimagingElectroencephalographyNeurophysiologyAtomic and Molecular Physics and Opticsmedicine.anatomical_structureFPGA Brain Oxygenation Map clinical brain monitoringScalpSettore ING-INF/06 - Bioingegneria Elettronica E Informaticasilicon photomultipliers.Neurovascular couplingsilicon photomultipliers030217 neurology & neurosurgeryfunctional near infrared spectroscopy (fNIRS)

description

Portable neuroimaging technologies can be employed for long-term monitoring of neurophysiological and neuropathological states. Functional Near-Infrared Spectroscopy (fNIRS) and Electroencephalography (EEG) are highly suited for such a purpose. Their multimodal integration allows the evaluation of hemodynamic and electrical brain activity together with neurovascular coupling. An innovative fNIRS-EEG system is here presented. The system integrated a novel continuous-wave fNIRS component and a modified commercial EEG device. fNIRS probing relied on fiberless technology based on light emitting diodes and silicon photomultipliers (SiPMs). SiPMs are sensitive semiconductor detectors, whose large detection area maximizes photon harvesting from the scalp and overcomes limitations of fiberless technology. To optimize the signal-to-noise ratio and avoid fNIRS-EEG interference, a digital lock-in was implemented for fNIRS signal acquisition. A benchtop characterization of the fNIRS component showed its high performances with a noise equivalent power below 1 pW. Moreover, the fNIRS-EEG device was tested in vivo during tasks stimulating visual, motor and pre-frontal cortices. Finally, the capabilities to perform ecological recordings were assessed in clinical settings on one Alzheimer&rsquo

yearjournalcountryeditionlanguage
2020-05-16Sensors
https://doi.org/10.3390/s20102831