Search results for "MLL"
showing 6 items of 6 documents
A novel high-spin heterometallic Ni12K4cluster incorporating large Ni–azide circles and an in situ cyanomethylated di-2-pyridyl ketone
2005
Reaction of di-2-pyridyl ketone (dpk) with nickel acetate and azide in the presence of potassium tert-butylate as a catalytic base generates the title compound, which contains the largest [Ni(m1,1-N3)]6 circles in the discrete ferromagnetically-coupled MII–azide cluster family, and shows an unprecedented in situ cyanomethylation of ketone. Clemente Juan, Juan Modesto, Juan.M.Clemente@uv.es
Symplekin, a polyadenylation factor, prevents MOZ and MLL activity on HOXA9 in hematopoietic cells
2013
International audience; MOZ and MLL encoding a histone acetyltransferase and a histone methyltransferase, respectively, are targets for recurrent chromosomal translocations found in acute myeloblastic or lymphoblastic leukemia. We have previously shown that MOZ and MLL cooperate to activate HOXA9 gene expression in hematopoietic stem/progenitors cells. To dissect the mechanism of action of this complex, we decided to identify new proteins interacting with MOZ. We found that the scaffold protein Symplekin that supports the assembly of polyadenylation machinery was identified by mass spectrometry. Symplekin interacts and co-localizes with both MOZ and MLL in immature hematopoietic cells. Its …
Heavy quark flavour dependence of multiparticle production in QCD jets
2010
After inserting the heavy quark mass dependence into QCD partonic evolution equations, we determine the mean charged hadron multiplicity and second multiplicity correlators of jets produced in high energy collisions. We thereby extend the so-called dead cone effect to the phenomenology of multiparticle production in QCD jets and find that the average multiplicity of heavy-quark initiated jets decreases significantly as compared to the massless case, even taking into account the weak decay products of the leading primary quark. We emphasize the relevance of our study as a complementary check of b-tagging techniques at hadron colliders like the Tevatron and the LHC.
Three-particle correlations in QCD jets and beyond
2011
In this paper, we present a more detailed version of our previous work for three-particle correlations in quark and gluon jets [1]. We give theoretical results for this observable in the double logarithmic approximation and the modified leading logarithmic approximation. In both resummation schemes, we use the formalism of the generating functional and solve the evolution equations analytically from the steepest descent evaluation of the one-particle distribution. In addition, in this paper we include predictions beyond the limiting spectrum approximation and study this observable near the hump of the single inclusive distribution. We thus provide a further test of the local parton hadron d…
Control of the HOXA9 gene expression in the hematopoietic stem/progenitor cells : role of the epigenetic factors MOZ, MLL and of the polyadenylation …
2013
My thesis project has consisted of the study of MOZ, and MLL. They are epigenetic regulators. MOZ and MLL activate transcription of HOX genes, which are transcription factors essential during haematopoiesis. MOZ and MLL have some target genes in common. In our study, we characterised a cooperation between MOZ and MLL in human haematopoietic stem/progenitor cells CD34+. They are both recruited onto HOX promoters. MOZ is essential for MLL recruitment, and this is reciprocal. In conclusion, we provided an example of a mechanism involving a direct cross-talk between two histone modifying enzymes.In order to dissect the mechanism of action of this complex, we decided to identify novel proteins i…
Leucemia linfoblástica aguda en niños menores de 1 año. Análisis de la supervivencia tras tratamiento con un protocolo específico (LAL-LACTANTES/SHOP…
2019
Mientras que en el niño mayor de 1 año la leucemia linfoblástica aguda (LLA) es el cáncer más frecuente, en los menores de 1 año se trata de una enfermedad rara y supone entre el 2-5% de la LLA pediátrica. Pese a su rareza, la LLA del lactante es de gran interés debido a la presentación clínica agresiva en un huésped especialmente vulnerable. A pesar de los múltiples avances en el tratamiento de la LLA en la infancia, el pronóstico de los niños menores de 12 meses sigue siendo pobre presentando este grupo mayor morbimortalidad que los niños mayores. La supervivencia global oscila entre el 40-50%, según los últimos estudios. En España los datos registrados de los lactantes con LLA incluidos …