Search results for "MMP"

Verenkierron MMP-entsyymien ja Fas-ligandin yhteydet eri-ikäisten naisten kehonkoostumukseen ja hormonaaliseen tilaan

2016

Ikääntyvillä ihmisillä kehon koostumuksen muuttuminen yhdessä lihaksiston heikentymisen kanssa on merkittävä toimintakykyyn ja elämänlaatuun vaikuttava tekijä. Ikääntyessä yleisesti vaikeutunut liikkuminen, korkeampi kaatumisen riski sekä metaboliseen oireyhtymään ja/tai tyypin II diabetekseen sairastuminen voivat olla seurauksia heikentyneestä toimintakyvystä. Naisilla vaihdevuosien aikana estrogeenin tuotanto vähenee huomattavasti, ja estrogeenin vähenemisen on havaittu olevan yhteydessä rasvakudoksen määrän lisääntymiseen, lihasten koon pienenemiseen ja lihasvoiman heikkenemiseen. Vaihdevuosien oireita hoidetaan mm. estrogeenia sisältävällä hormonikorvaushoidolla, mutta estrogeenin vaiku…

Formulative and stability studies of a Citrus extract to produce novel “healthy food"

2015

DSM-5 alternatīvajā personības traucējumu modelī iekļauto personības traucējumu iezīmju saistība ar MMPI-2 testa skalām

2019

Pētījuma mērķis bija izvērtēt saistību starp Psihisko traucējumu diagnostikas un statistikas rokasgrāmatas piektajā izdevumā (Diagnostic and Statistical Manual of Mental Disorders, 5th edition – DSM-5) iekļautā alternatīvā modeļa (Sadaļa III) dimensionālām personības traucējumiem raksturīgām personības iezīmēm, mērītām ar DSM-5 Personības Aptauju (PID-5) un Minesotas daudzfaktoru personības testa otrās redakcijas (Minnesota Multiphasic Personality Inventory 2 - MMPI-2) testa skalām, psihiatrisko pacientu izlasē. Kā papildus mērķis tika izvirzīts PID-5 (Personality Inventory for DSM-5) adaptācija un psihometrisko rādītāju pārbaude Latvijas izlasē. Pētījuma kopēju izlasi veidoja 317 Latvijas …

ADIPONECTIN, LEPTIN AND MMP-3 PLASMATIC LEVELS CANNOT IDENTIFY HIGH-RISK PROSTATE CANCER IN PATIENTS UNDERGOING BIOPSY

2016

PMMP:n lyriikoiden naiskuvat rockin maskuliinisessa maailmassa

2012

AGE6. Skin Ageing: Focus on the Role of Inflammatory Genetic Factors in Cutaneous Neoplasia

2014

AGE6. Skin Ageing: Focus on the Role of Inflammatory Genetic Factors in Cutaneous Neoplasia C. M. Gambino1, F. Crapanzano1, G. Accardi1, A. Aiello1, C. Virruso1, G. Pistone1, M. R. Bongiorno1, D. Lio1, C. R. Balistreri1, G. Candore1 1University of Palermo, Palermo, Italy Background: Skin aging is a complex process that involves intrinsic and exogenous causes. Photo-oxidative damage caused by UV is the leading cause of extrinsic aging of the skin, known as photo-ageing. UV damages can be linked mostly to overproduction of ROS that induces a complex molecular cascade able to accelerate physiological aging, determining a typical dermal/epidermal inflammation with an increased risk of getting s…

Effects of ectopic expression of NGAL on doxorubicin sensitivity.

2012

Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are important in the transport of iron. NGAL also has important biological functions involved in immunity and inflammation as well as responses to kidney damage. NGAL expression has also been associated with certain neoplasia and is important in the metastasis of breast cancer. Many advanced cancer patients have elevated levels of NGAL in their urine and it has been proposed that NGAL may be a prognostic indicator for certain cancers (e.g. breast, brain, and others). NGAL exp…

The matrix metalloproteinase and insulin-like growth factor system in oral cancer : a prospective clinical study

2017

Aim The absence of reliable single serum biomarkers for oral premalignant lesion (OPL) and oral squamous cell carcinoma (OSCC) limits early diagnosis, monitoring of advanced disease, and prediction of prognosis. Methods In this prospective study, serum levels of matrix metalloproteinase (MMP)-2, MMP-3, MMP-13, insulin-like growth factor (IGF)-1, and IGF-binding protein (IGFBP)-3 were measured in 81 untreated OSCC patients, 49 healthy subjects, and 75 individuals with OPLs, and correlated with clinicopathological parameters. Results Serum levels of MMP-3 were significantly higher in OSCC patients compared to healthy subjects (p=0.004). Mean IGF-1 and IGFBP-3 levels in OSCC patients were sign…

Genetic Factors as Promising Biomarkers of Sporadic Ascending Aortic Aneurysm

2014

Thoracic aorta shows various changes with advancing age and a progressive deterioration in structure and function. As a result, vascular remodeling (VR) and medial degeneration (MD) occur. VR and MD are typical entities of sporadic thoracic aortic aneurysm (TAA), actually considered a common and serious health risk and a pathology by unclear mechanisms. Increased activity of the coagulation system, inflammation, activation of extracellular matrix remodeling and endothelial dysfunction pathways have been recently evidenced to have a key role in its onset. Thus, polymorphisms of the coagulation system [fibrinogen (rs1800790); Factor II ( rs1799963); Factor V (rs6025); Factor VII (rs121964926)…