Search results for "MOA"
showing 10 items of 103 documents
Strength Training Improves Metabolic Health Markers in Older Individual Regardless of Training Frequency
2019
The main purpose of the present study was to investigate the effect of frequency, thereby increasing training volume, of resistance training on body composition, inflammation markers, lipid and glycemic profile in healthy older individuals (age range 65–75 year). Ninety-two healthy participants were randomly assigned to one of four groups; performing strength training one- (EX1), two- (EX2), or three- (EX3) times-per-week and a non-training control (CON) group. Whole-body strength training was performed using 2–5 sets and 4–12 repetitions per exercise and 7–9 exercises per session. All training groups attended supervised resistance training for 6 months. Body composition was measured by dua…
Pokolenie X i Y - podobieństwa i różnice w osobowości i hierarchii wartości między kierownikami a pracownikami na tle poczucia jakości życia
2014
Professional competences: Personality and Axiological Model (MOA) in verifying the sense of life quality
2016
Testowane w prezentowanym badaniu hipotezy zostały sformułowane w oparciu Model Osobowościowo-Aksjologiczny MOA B. Mróz, który zakłada, że poczucie jakości życia u pracowników wyższego szczebla jest uwarunkowane takimi wymiarami osobowościowo-aksjologicznymi, jak: struktura potrzeb, przystosowanie, osiągnięcia i wartości. W badaniach zastosowano: Test ACL, Wskaźnik Osiągnięć Zawodowych WOZ, Test Niedokończonych Zdań (RISB), Skalę Wartości Rokeacha oraz Kwestionariusz Poczucia Jakości Życia (KPJŻ). Za pomocą analizy regresji oraz równań strukturalnych oceniono wpływ badanych zmiennych. Okazało się, że model MOA różnicuje pracowników wyższego szczebla. Współczynnik determinacji uzyskał 47% wa…
Art of Acting and Management Style. Results of psychological research on personality and hierarchy of values of outstanding Polish actors and manager…
2018
The article – which is based on the need theory proposed by McClelland and the author’s theoretical and empirical Personality and Axiological Model – deals with the research on two groups of professionally engaged individuals: outstanding Polish actors and managers in the area of services. The results obtained indicate a significant diversity of the groups in terms of personality traits and the hierarchy of values as well as the consistency of the image in the scope of significance of dimensions related to competence and autonomy. The sphere of motivation in both groups studied is remarkably similar as well. The results show that individuals who are effective and expect professional achieve…
Monoclonal antibodies for the treatment of non-haematological tumours: update of an expanding scenario.
2015
Abstract: Introduction: The identification of cell membrane-bound molecules with a relevant role in cancer cell survival prompted the development of moAbs to block the related pathways. In the last few years, the number of approved moAbs for cancer treatment has constantly increased. Many of these drugs significantly improved the survival outcomes in patients with solid tumours. Areas covered: In this review, all the FDA-approved moAbs in solid tumours have been described. This is an update of moAbs available for cancer treatment nowadays in comparison with the moAbs approved until few years ago. The moAbs under development are also discussed here. Expert opinion: The research on cancer ant…
Profiling microbial communities in hyperalkaline waters of the Kizildag ophiolite complex (Turkey).
2016
It has recently been hypothesized that life on Earth could have been originated in hyperalkaline waters related to serpentinization of ophiolitic rocks, despite their extreme conditions (high pH and very low levels of nutrients). Five hyperalkaline springs of the Kizildag ophiolite complex (Turkey) were characterized. The dominant gases are either H2, CH4 or N2 . Bacterial diversity, analysed by RISA (Ribosomal Intergenic Spacer Analysis) revealed different profles for each spring. Sequencing of excised DNA bands allowed to identify the presence of Bacillus, Ralstonia, Pseudoalteromonas., Ureibacillus, Alicycliphilus, Anaerococcus. 16S ribosomal DNA sequencing by Illumina is in progress. Th…
The Role of Fc Receptors on the Effectiveness of Therapeutic Monoclonal Antibodies.
2021
Since the approval of the first monoclonal antibody (mAb) in 1986, a huge effort has been made to guarantee safety and efficacy of therapeutic mAbs. As of July 2021, 118 mAbs are approved for the European market for a broad range of clinical indications. In order to ensure clinical efficacy and safety aspects, (pre-)clinical experimental approaches evaluate the respective modes of action (MoA). In addition to antigen-specificity including binding affinity and -avidity, MoA comprise Fc-mediated effector functions such as antibody dependent cellular cytotoxicity (ADCC) and the closely related antibody dependent cellular phagocytosis (ADCP). For this reason, a variety of cell-based assays have…
Monoklonālās antivielas - mūsdienu ārstēšanas iespējas
2018
Biozāles ir viens no straujāk augošajiem farmaceitiskās rūpniecības segmentiem veselības aprūpē. Rekombinantās DNS tehnoloģijas un hibridomu tehnoloģijas progress, ir izraisījis liela mēroga proteīnu ražošanu, kuriem ir potenciāli terapeitiski pielietojumi. Kopš 1975. gada, kad pirmo reizi ziņots par monoklonālo antivielu (moAv) attīstību, pagājuši vairāk kā 40 gadi un apmēram 100 terapeitiskās moAv ir apstiprinātas kā zāles, kuras galvenokārt pielieto onkoloģisku un autoimūnu slimību terapijā. Šī pētījuma mērķis bija apzināt ārstu zināšanas par moAv un, noskaidrot ārstu pieredzi un iespējas moAv terapijas pielietošanai Latvijā. Tika veikta aptauja, kurā piedalījās 67 respondenti. Pēc aptau…
Neridronate prevents bone loss in patients receiving androgen deprivation therapy for prostate cancer.
2004
Today, androgen deprivation therapy is a cornerstone of treatment for advanced prostate cancer, although it presents important complications such as osteoporosis. Neridronate, a relatively new bisphosphonate, is able to prevent bone loss in patients with prostate cancer during androgen ablation. Introduction: Androgen-deprivation therapy (ADT) is a cornerstone of treatment for advanced prostate cancer. This therapy has iatrogenic complications, such as osteoporosis. The aim of our study was to evaluate the efficacy of neridronate, a relatively new bisphosphonate, to prevent bone loss during androgen ablation. Materials and Methods: Forty-eight osteoporotic patients with prostate cancer, tre…
La genitorialità nella coppia omoaffettiva
2020
Il saggio affronta il delicato tema della aspirazione alla genitorialità procreativa da parte delle coppie omoaffettive nel nostro ordinamento alla luce dei divieti legislativi e del diritto vivente, considerati nel quadro dei principi costituzionali di riferimento. Indica argomenti e possibili soluzioni ermeneutiche per affermare un diritto alla genitorialità e per offrire adeguata copertura giuridica alla posizione del nato. The essay deals with the delicate issue of the aspiration to procreative parenthood by homosexual couples in our legal system in the light of the relevant legislative prohibitions and the recent case-law, considered within the framework of the constitutional principle…