Search results for "MOBILITY"
showing 10 items of 922 documents
p53-Mediated downregulation of H ferritin promoter transcriptional efficiency via NF-Y.
2008
The tumor suppressor protein p53 triggers many of the cellular responses to DNA damage by regulating the transcription of a series of downstream target genes. p53 acts on the promoter of the target genes by interacting with the trimeric transcription factor NF-Y. H ferritin promoter activity is tightly dependent on a multiprotein complex called Bbf; on this complex NF-Y plays a major role. The aim of this work was to study the modulation of H ferritin expression levels by p53. CAT reporter assays indicate that: (i) p53 overexpression strongly downregulates the transcriptional efficiency driven by an H ferritin promoter construct containing only the NF-Y recognition sequence and that the phe…
Satb2 Regulates Callosal Projection Neuron Identity in the Developing Cerebral Cortex
2008
SummarySatb2 is a DNA-binding protein that regulates chromatin organization and gene expression. In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the corpus callosum. To assess the role of Satb2 in neurons, we analyzed mice in which the Satb2 locus was disrupted by insertion of a LacZ gene. In mutant mice, β-galactosidase-labeled axons are absent from the corpus callosum and instead descend along the corticospinal tract. Satb2 mutant neurons acquire expression of Ctip2, a transcription factor that is necessary and sufficient for the extension of subcortical projections by cortical neurons. Conversely, ectopic expression of Satb2 in neural stem cells m…
Molecularly imprinted polymer-based device for field collection of oral fluid samples for cocaine identification.
2020
In this paper, a low-cost, rapid, easy, and potentially portable tool for the identification of cocaine and its semi-quantitative determination in oral fluid has been proposed. A field collection device has been designed, based on a cotton pad with an indicator and a molecularly imprinted polymer (MIP) sorbent, to selective retain cocaine from oral fluid components. After sample collection, cocaine is transferred by using phosphate buffer to the MIP and then eluted with 2-propanol. The obtained extract is analysed by ion mobility spectrometry (IMS), providing a cut-off value of 20 µg L-1 that identifies 100 % true-positive and 95 % true-negative samples. The MIP-IMS procedure has been valid…
Bio-phenols determination in olive oils: Recent mass spectrometry approaches
2021
Extra virgin olive oil (EVOO) is largely used in Mediterranean diet, and it is also worldwide apprised not only for its organoleptic properties but also for its healthy effects mainly attributed to the presence of several naturally occurring phenolic and polyphenolic compounds (bio-phenols). These compounds are characterized by the presence of multiple phenolic groups in more or less complex structures. Their content is fundamental in defining the healthy qualities of EVOO and consequently the analytical methods for their characterization and quantification are of current interest. Traditionally their determination has been conducted using a colorimetric assay based on the reaction of Folin…
European National Road Authorities and Circular Economy: An Insight into Their Approaches
2020
The pavement engineering industry, having realized the significance of the impacts that it imposes on the environment through the production, construction and management of its products and assets, has been driven towards a more sustainable and circular way of operating. This has partly been through asphalt recycling, which is an area that many road authorities have prioritized. However, not all the National Road Authorities (NRAs) and/or sector stakeholders seem to be adequately familiar with the Circular Economy (CE) concept. This paper attempts to assist the transition of NRAs to a more circular way of doing business, by analyzing the current situation of CE within national/regional auth…
Conversion as Negotiation. Converts as Actors of Civil Society
2020
This article focuses on the religious movement of the Ahmadiyya and its civil society organization, Humanity First, in West-Africa and in Europe. Particular attention is paid to the place of converts within these two institutions. Conversions to an Islamic minority and the actions of this minority are studied through the prism of social commitment. I examine the intersections between religious values, the ideas of solidarity in the societies under scrutiny and, the kaleidoscopic range of Muslim charities. The paper investigates conversion as negotiation in regard to gender, social mobility, and power. Conversion is approached here as a matter of social relations and not personal belief. I a…
Producing social mobility. Class and Travel in the Romanian Novel 1901-1932
2020
The present article addresses the Romanian novelistic production between 1901 and 1932 in the attempt of identifying a series of patterns regarding the protagonists’ social mobility. Starting with the most mentioned destinations throughout the novels, I analyse how and why the different social classes travel and try to determine the landmarks between which they dispute their physical presence, on the one hand, and their aspirations, on the other. On this basis, the second part of the article conducts a quantitative analysis of the major means of transport in the period – the train, the tramway, the coach/carriage, the automobile, the aeroplane, the ship, and the waggon – and attempts to pin…
Unveiling anion-induced folding in tripodal imidazolium receptors by ion-mobility mass spectrometry.
2021
The anion-induced folding of tripodal imidazolium receptors has been investigated by NMR spectroscopy, electrospray ionization ion mobility mass spectrometry and DFT calculations. Such folding can be switched by anion release upon collision induced dissociation.
Why do Norwegian nurses leave the public health service to practice CAM?
2009
Accepted version of an article published in Complementary Therapies in Clinical Practice, 15 (2009), 147-151 This paper explores a number of issues associated with the recent increase in nurses choosing to leave the Norwegian health care system in order to become independent practitioners of complementary and alternative medicine (CAM). The paper suggests that in Norway, nurses perceive medical hegemony continues to persist. Nurses perceive restrictions in their ability to develop their professional roles and status. CAM would appear to offer many nurses, the opportunity to develop their clinical skills in an autonomous, egalitarian and more holistic environment.
Comment on: A critical analysis of the internal logic in the Life-Space Assessment (LSA) composite score and suggested solutions
2016
Background:An individual’s ability to live independently is commonly measured in health research interested in identifying risk factors associated with disablement processes. In order to inform clinical practice, population research has attempted to identify the contraction of “lived-space” by using various survey instruments.Problem:Studies assessing habitual movements over the environment with the Life-Space Assessment (LSA) survey instrument should carefully consider how the LSA Composite Score (LSA-CS) is computed. Until now, no publication has carefully delineated the assumptions guiding the internal logic used in the computation of the LSA-CS.Core argument:Because the internal logic o…