Search results for "MOBILIZATION"
showing 10 items of 142 documents
Rituximab in vivo purging is safe and effective in combination with CD34-positive selected autologous stem cell transplantation for salvage therapy i…
2002
The purpose of this study was to evaluate feasibility and efficacy of Rituximab included into a sequential salvage protocol for CD20(+) B-NHL in relapse or induction failure. Twenty-seven patients with CD20(+) B-NHL in relapse or induction failure received Rituximab combined with DexaBEAM (R-DexaBEAM) for stem cell mobilization. Additional ex vivo selection of CD34-positive cells was performed using the CliniMacs device. Two doses of Rituximab were included in the high-dose therapy regimen (HDT). R-DexaBEAM was well tolerated and 26 of 27 patients mobilized sufficient numbers of CD34(+) blood stem cells. Application of R-DexaBEAM resulted in significant depletion of peripheral B cells. No t…
Rituximab combined with DexaBEAM followed by high dose therapy as salvage therapy in patients with relapsed or refractory B-cell lymphoma: mature res…
2014
Summary Salvage therapy followed by high-dose therapy (HDT) remains a mainstay for patients with relapsed lymphoma, however no optimal regimen has been defined. Here we report on the results of R-DexaBEAM (rituximab, dexamethasone, carmustine, etoposide, cytarabine, melphalan) followed by HDT. Patients aged 18–65 years, Eastern Cooperative Oncology Group performance score 0–2, with relapsed/refractory B-cell non-Hodgkin lymphoma (NHL) were eligible. R-Dexa-BEAM was given for two cycles followed by stem cell mobilization and HDT. Primary endpoint of the trial was progression-free-survival (PFS). One hundred and three patients were included: aggressive NHL (aNHL): diffuse large B-cell lymphom…
Effect of Streptomyces coelicolor M145 cell immobilization on actinorhodin production
2016
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Fracturas de radio distal. ¿Progresa el desplazamiento entre la segunda y la sexta semana?.
2020
espanolLas fracturas de radio distal son las mas frecuentes en nuestra especialidad. El tratamiento conservador con inmovilizacion, basado en una serie de parametros radiologicos, sigue siendo el mas utilizado hoy en dia. El objetivo de nuestro estudio ha sido evaluar el desplazamiento secundario de estas fracturas entre la segunda y sexta semana de evolucion. Para ello hemos evaluado las fracturas de radio distal tratadas de forma conservadora en nuestro Servicio, durante el ano 2016. De un total de 53 fracturas de muneca tratadas de forma conservadora, un 49% de los casos presento algun tipo de desplazamiento, si bien la mayor parte de estos tuvieron lugar antes de la segunda semana. Nues…
‘Dead men walking?’ Party identification in Germany, 1977–2002
2006
Abstract Scholars engaged in the discourse on ‘Parteienverdrossenheit’ claim that a breakdown of party attachments in West Germany occurred during the early 1990s. Employing data from a series of monthly polls that were conducted from 1977 to 2002, this paper demonstrates that the notion of such a rapid decline is wrong. Rather than being swept away by political crises, party identification declines slowly and fairly constantly over time, which is in line with theories of a secular dealignment. Furthermore, it can be shown that this dealignment is driven by a weakening of traditional social ties, while cognitive mobilization and change in the composition of the society have no effect on par…
Historicizing Divergence: A Comparative Analysis of the Revolutionary Crises in Russia and Finland
2016
Beginning 1917, Russia and Finland both experienced revolutionary situations, the seizure of power by radical political groups, and civil wars. However, the ultimate outcomes of the revolutionary crises in the two countries turned out to be different: the Russian Bolsheviks won the struggle for power whereas the Finnish Red Guard suffered a defeat. Why did the radical socialists win in Russia but lose in Finland? This chapter argues that the Russian revolutionaries benefited from the existence of two coalition alliances that had not fully materialized in Finland: the workers–soldiers’ alliance, which was critical for the radicals’ seizure of power, and the workers–peasants’ alliance, which …
C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair After Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-R…
2019
Background: Acute myocardial infarction (MI) elicits an inflammatory response that drives tissue repair and adverse cardiac remodeling. Inflammatory cell trafficking after MI is controlled by C-X-C motif chemokine ligand 12 (CXCL12) and its receptor, C-X-C motif chemokine receptor 4 (CXCR4). CXCR4 antagonists mobilize inflammatory cells and promote infarct repair, but the cellular mechanisms are unclear. Methods: We investigated the therapeutic potential and mode of action of the peptidic macrocycle CXCR4 antagonist POL5551 in mice with reperfused MI. We applied cell depletion and adoptive transfer strategies using lymphocyte-deficient Rag1 knockout mice; DEREG mice, which express a diphth…
De las rentas mínimas a la renta básica de las iguales y mucho más
2010
El presente artículo describe la Renta Básica de las Iguales y la contrapone a las rentas mínimas, incluyendo una descripción de la renta garantizada de ciudadanía del País Valencià. La Renta Básica de las Iguales es una herramienta de transformación social vinculada a una intervención social emancipadora The present article describes Citizens' Basic Income, and sets this in contrast to minimum incomes, including a description of the guaranteed citizenship income of the País Valencià. Citizens' Basic Income is a tool for social transformation linked to emancipating social intervention.
Palermo si cura. Pratiche culturali di mutuo soccorso come risposta alle fragilità della città (post)pandemica
2023
In un quadro di riferimento in cui la crisi è globalizzata ma diseguale e in mancanza di un sistema di welfare capace di rispondere alle urgenze dei contesti e dei gruppi sociali più marginalizzati, una risposta ai nuovi bisogni sociali ed individuali è stata offerta da reti solidali e da pratiche di mobilitazione dal basso che svolgono un ruolo di agency territoriale, spesso indipendentemente o in assenza di Istituzioni. Nel contesto palermitano un impegno agito da una pluralità di soggetti culturali già attivi sul territorio, riuniti in un’assemblea pubblica (Palermo si cura), durante il periodo del primo lockdown hanno dato vita ad azioni di mutuo soccorso per rispondere all’emergenza ec…
PCL/PEG based membranes for bacterial cells immobilization stimulate actinorhodin antibiotic production in S. coelicolor
2015
The actinomycetes, Gram-positive filamentous bacteria, are the most prolific source of natural antibiotics. At industrial level, antibiotics from actinomycetes are usually produced at low levels by mean of fermentative processes in submerged cultivations, where one of the major factors negatively affecting bioproductivity is the phenomenon of a pellet-shaped biomass growth. The strategies based on cell-immobilization, which were already proven improving bacterial bioprocess productivity, could stimulate antibiotic production in actinomycetes.