Search results for "MR"
showing 10 items of 3001 documents
Growth rate of small (≤2 cm) HCC in cirrhotic patient: determining optimal screening interval with serial CT or MRI.
2009
Vascular disorders of the liver
2008
Evidence for Human Adaptation and Foodborne Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus
2016
We investigated the evolution and epidemiology of a novel livestock-associated methicillin-resistant Staphylococcus aureus strain, which colonizes and infects urban-dwelling Danes even without a Danish animal reservoir. Genetic evidence suggests both poultry and human adaptation, with poultry meat implicated as a probable source.
Localizzazione ipocentrale e clustering degli eventi sismici registrati durante la campagna OBS condotta nel Tirreno meridionale
2011
IGF2BP3 Associates with Proliferative Phenotype and Prognostic Features in B-Cell Acute Lymphoblastic Leukemia
2021
Simple Summary Although the prognosis of acute lymphoblastic leukemia (ALL) has improved significantly during the past decades, ALL remains a major cause of pediatric cancer mortality, and more accurate risk-stratification is required. We investigated IGF2BP3, which has previously been associated with aggressive cancers, and found high and subtype-specific expression of IGF2BP3 in B-cell ALL, that was associated with good outcome in high-risk patients. Results suggest that IGF2BP3 could be useful to improve stratification and prognosis of B-ALL. Abstract The oncofetal protein insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) belongs to a family of RNA-binding proteins involved i…
Xrn1 influence on gene transcription results from the combination of general effects on elongating RNA pol II and gene-specific chromatin configurati…
2020
mRNA homoeostasis is favoured by crosstalk between transcription and degradation machineries. Both the Ccr4-Not and the Xrn1-decaysome complexes have been described to influence transcription. While Ccr4-Not has been shown to directly stimulate transcription elongation, the information available on how Xrn1 influences transcription is scarce and contradictory. In this study we have addressed this issue by mapping RNA polymerase II (RNA pol II) at high resolution, using CRAC and BioGRO-seq techniques in Saccharomyces cerevisiae. We found significant effects of Xrn1 perturbation on RNA pol II profiles across the genome. RNA pol II profiles at 5ʹ exhibited significant alterations that were com…
Molecular cloning and characterization of the complementary DNA coding for the B-chain of murine Clq
1989
AbstractcDNA clones coding for the B-chain of murine Clq were isolated from a mouse macrophage library. The characterized clones include the total coding region plus a leader sequence. High homology was found with human Clq B-chain in the coding region (81%). Northern blot analysis of total RNA from different tissues of Balb/c mice showed one band of approximately 1.2 kb. The highest signal was found in RNA preparations of thioglycolate-activated peritoneal macrophages. The probe also hybridized with mRNA from spleen, thymus and heart. Extremely weak signals were found in liver, kidney, lung and intestine tissues.
Detection of mRNA with DNA probes using transmission electron microscope
2006
Alfavīrusu genomiskās RNS piegāde audzēju šūnu kultūrās, izmantojot lipofilos 1,4-dihidropiridīna atvasinājumus
2015
Alfavīrusu genoms ir aptuveni 11,5 kb gara vienpavediena, pozitīvas ķēdes RNS, kuru ir potenciāls izmantot antigēnu kodējošu, pašamplificējošu RNS vakcīnu izstrādē. Lai veidotu stabilu piegādes sistēmu bieži tiek izmantoti lipofili aģenti ar katjonu īpašībām, piemēram, 1,4-dihidropiridīna atvasinājumi. Šādi lipopleksi jau ir uzrādījuši teicamus rezultātus nukleīnskābju vakcīnu preparātu izstradē. Salīdzinot ar virālajām piegādes sistēmām, tiek apietas problēmas, kas saistītas ar anti-vektora imunitāti, citotoksicitāti un biodrošību. Šajā darbā tika veikta alfavīrusu genomiskās RNS rekSFV1/Ds-Red un 1,4-dihidropiridīnu atvasinājumu lipopleksu veidošanas optimizācija, lai panāktu maksimāli ef…
Kardiovaskulāro riska faktoru un slimību profils pacientiem pēc pārciesta cerebrāla infarkta a.cerebri media sinistra baseinā
2019
Insults ir viens no vadošajiem nāves cēloņiem pasaulē un vadošais nespējas cēlonis. Pacienta funkcionālā nespēja pēc pārciesta insulta ir daudz būtiskāka salīdzinot ar mirstību, pasliktinot dzīves kvalitāti, izolējot pacientu no sabiedrības un ietekmējot veselības aprūpes izmaksu slogu gan pacientam, gan valstij. Pētījuma mērķis: Noskaidrot cerebrāla infarkta (CI) kardiovaskulāros riska faktorus un slimību profilu, izvērtēt kuri faktori ietekmē CI neiroloģisko iznākumu. Metodika un materiāli: Tika veikts retrospektīvs pētījums Paula Stradiņa Klīniskās Universitātes slimnīcas arhīvā. Pētāmā populācija: 20. nodaļas pacienti ar diagnozi pēc SKK-10 šifra I63.3- išēmisks insults. No tiem tika at…