Search results for "MRI"

What we learn about bipolar disorder from large-scale neuroimaging

2020

Abstract MRI‐derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta‐Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis‐driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Workin…

The relationship between navigation abilities and mental disorders: Poster

2021

This study examined the relationship between aspects of navigational ability and behavioral traits associated with various mental disorders. We propose that navigational ability may utilize the same brain circuitry that has dysfunction in certain mental disorders and may be a beneficial early marker for these disorders. This study was inspired by the Research Domain Criteria (RDoC), a framework outlined by NIMH to study the basic dimensions of functioning that span the range of behavior from normal to abnormal. For example, we hypothesized that spatial perspective taking, which is important for navigation, could be associated with social perspective taking in disorders such as autism spectr…

The relationship between navigation abilities and mental disorders: Oral presentation

2021

Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI

2004

Gradient echo T2*-weighted MRI has high sensitivity in detecting cerebral microbleeds, which appear as small dot-like hypointense lesions. Microbleeds are strongly associated with intracerebral haemorrhage, hypertension, lacunar stroke and ischaemic small vessel disease, and have generated interest as a marker of bleeding-prone microangiopathy. Microbleeds have generally been considered to be clinically silent; however, since they are located in widespread cortical and basal ganglia regions and are histologically characterized by tissue damage, we hypothesized that they would cause cognitive dysfunction. We therefore studied patients with microbleeds (n = 25) and a non-microbleed control gr…

Consistency of Independent Component Analysis for FMRI

2021

Background Independent component analysis (ICA) has been widely used for blind source separation in the field of medical imaging. However, despite of previous substantial efforts, the stability of ICA components remains a critical issue which has not been adequately addressed, despite numerous previous efforts. Most critical is the inconsistency of some of the extracted components when ICA is run with different model orders (MOs). New Method In this study, a novel method of determining the consistency of component analysis (CoCA) is proposed to evaluate the consistency of extracted components with different model orders. In the method, “consistent components” (CCs) are defined as those whic…

Tensor clustering on outer-product of coefficient and component matrices of independent component analysis for reliable functional magnetic resonance…

2019

Background. Stability of spatial components is frequently used as a post-hoc selection criteria for choosing the dimensionality of an independent component analysis (ICA) of functional magnetic resonance imaging (fMRI) data. Although the stability of the ICA temporal courses differs from that of spatial components, temporal stability has not been considered during dimensionality decisions. New method. The current study aims to (1) develop an algorithm to incorporate temporal course stability into dimensionality selection and (2) test the impact of temporal course on the stability of the ICA decomposition of fMRI data via tensor clustering. Resting state fMRI data were analyzed with two popu…

Effects of the static magnetic field generated by a 1,5 T MRI unit on TNF-a release and TNF-receptor II expression of human monocyes

2008

NEW FRICKE GEL WITH HIGH SENSITIVITY AND LOW DIFFUSION FOR3D-MRI DOSIMETRY

2019

Analysis of signal-to-noise ratio for a 2-channels coil developed to enable transcranial Magnetic Resonance-guided Focused Ultrasound Surgery (tcMRgF…

2018

The relationship between electrophysiological and hemodynamic measures of neural activity varies across picture naming tasks: A multimodal magnetoenc…

2022

Funding Information: This work was financially supported by the Academy of Finland (Finnish Center of Excellence in Computational Inference Research COIN and grants #292334, #294238 to SK; #255349, #315553 to RS; #257576 to JK; #286405 funding for TM), the Sigrid Jusélius Foundation (grant to RS), the Finnish Cultural Foundation (grant to ML), the Swedish Cultural Foundation in Finland (grant to ML), the Maud Kuistila Memorial Foundation (grant to ML), and Aalto Brain Center. Publisher Copyright: Copyright © 2022 Mononen, Kujala, Liljeström, Leppäaho, Kaski and Salmelin. Different neuroimaging methods can yield different views of task-dependent neural engagement. Studies examining the relat…