Search results for "MSC"

Reduced Neck Muscle Strength and Altered Muscle Mechanical Properties in Cervical Dystonia Following Botulinum Neurotoxin Injections : A Prospective …

2016

Cervical dystonia (CD) is a focal dystonia causing involuntary activation of neck and shoulder muscles resulting in abnormal, sustained and painful posturing that may lead to physical disability and social withdrawal [1]. In recent years, botulinum neurotoxin (BoNT) has become the first line therapy for CD [2]. A subjective feeling of neck weakness has been reported as one of the most common localized adverse events of BoNT [2-7]. In clinical practice, this may sometimes be reported as having difficulty keeping the head upright. Although the effects of BoNT have been widely studied [2,5], there have been no prospective studies quantifying changes in maximal isometric neck muscle strength. O…

Oral Propranolol for Circumscribed Choroidal Hemangioma

2011

Introduction: Several therapeutic approaches have been developed to treat choroidal hemangioma. However, all these therapies are associated with a potential risk of damaging the overlying retina. Case Report: We report a case of circumscribed choroidal hemangioma (CCH) in a 59-year-old man refractory to laser treatment. Visual acuity was 20/200 and a serous macular detachment was present. The CCH was treated with oral propanolol, whereupon visual acuity improved to 20/20 and the macular detachment resolved without systemic or local adverse effects. Discussion: Propanolol is a β-blocker commonly used in cardiology that may induce endothelium vasoconstriction and inhibit endothelial prolifera…

CHARACTERIZATION AND ENERGETIC METABOLISM ANALYSIS OF DIFFERENT POPULATIONS OF UMBILICAL CORD MESENCHYMAL STEM CELLS FOR THE TREATMENT OF STROKE

Stroke is a leading cause of death and disability worldwide. A direct consequence of oxygen and glucose deprivation during stroke is the dysfunction of mitochondria that impairs oxidative metabolism and contributes to oxidative stress, neuronal death and inflammation. Human umbilical cord (UC)-derived MSCs (UC-MSCs) are an attractive source for regenerative medicine purposes due to their self-renewal and multipotent differentiation potential, immunomodulatory and anti-inflammatory abilities. Notably, because UC is supplied from only three blood vessels, the UC-MSCs are physiologically adapted to survive in a relatively hypoxic and glucose poor environment leading to the hypothesis that thes…

Moment Map and Gelfand Transform for the Enveloping Algebra

2019

International audience; Describing the Gelfand construction for the analytic states on an universal enveloping algebra, we characterize pure states and re-find the main result of a preceding work with L. Abdelmoula and J. Ludwig on the separation of unitary irreducible representations of a connected Lie group by their generalized moment sets.

On time-harmonic Maxwell equations with nonhomogeneous conductivities : Solvability and FE-approximation

1989

The solvability of time-harmonic Maxwell equations in the 3D-case with non­homogeneous conductivities is considered by adapting Sobolev space technique and variational formulation of the probJem in question. Moreover, a finite element approximation is presented in the 3D·case together with an error estimate in the energy norm. Some remarks are given to the 2D-problem arising from geophysics. peerReviewed

Shape optimization in contact problems based on penalization of the state inequality

1986

The paper deals with the approximation of optimal shape of elastic bodies, uni­laterally supported by a rigid, frictionless foundation. Original state inequality, describing the behaviour of such a body is replaced by a family of penalized state problems. The relation between optimal shapes for the original state inequality and those for penalized state equations is established. peerReviewed

Nebanku kredītdevēju ”SMScredit” un ”InCREDIT GROUP” lojalitātes programmas un to novērtējums

2016

Bakalaura darba temats ir „Nebanku kredītdevēju ”SMScredit” un ”InCREDIT GROUP” lojalitātes programmas un to novērtējums.” Darba mērķis ir lojalitātes programmu komunikācijas kanālu vērtējums un klientu vērtējums par programmu noderīgumu, to priekšrocībām un vai programmu darbības principi klientiem ir saprotami. Darbs sastāv no trīs daļām: teorētiskās, metodoloģiskās un empīriskās daļas. Teorētiskajā daļā tiek pētīta literatūra par mārketingu, integrētā mārketinga komunikāciju, patērētāju uzvedību un klientu lojalitāti. Darba metodoloģiskajā daļā tiek aplūkota teorija par kvantitatīvo un kvalitatīvo pētījuma metodi – aptauju un fokusa grupu. Darba nobeigumā tiek izdarīti secinājumi, izvērt…

On a nonlinear Schrödinger equation for nucleons in one space dimension

2021

We study a 1D nonlinear Schrödinger equation appearing in the description of a particle inside an atomic nucleus. For various nonlinearities, the ground states are discussed and given in explicit form. Their stability is studied numerically via the time evolution of perturbed ground states. In the time evolution of general localized initial data, they are shown to appear in the long time behaviour of certain cases.

The Interconnecting Hairpin Extension "Arm": An Essential Allosteric Element of Phytochrome Activity

2023

In red-light sensing phytochromes, isomerization of the bilin chromophore triggers structural and dynamic changes across multiple domains, ultimately leading to control of the output module (OPM) activity. In between, a hairpin structure, "arm", extends from an interconnecting domain to the chromophore region. Here, by removing this protein segment in a bacteriophytochrome from Deinococcus radiodurans (DrBphP), we show that the arm is crucial for signal transduction. Crystallographic, spectroscopic, and biochemical data indicate that this variant maintains the properties of DrBphP in the resting state. Spectroscopic data also reveal that the armless systems maintain the ability to respond t…

Does reviewing experience reduce disagreement in proposals evaluation? Insights from Marie Skłodowska-Curie and COST Actions

2021

Abstract We have limited understanding of why reviewers tend to strongly disagree when scoring the same research proposal. Thus far, research that explored disagreement has focused on the characteristics of the proposal or the applicants, while ignoring the characteristics of the reviewers themselves. This article aims to address this gap by exploring which reviewer characteristics most affect disagreement among reviewers. We present hypotheses regarding the effect of a reviewer’s level of experience in evaluating research proposals for a specific granting scheme, that is, scheme reviewing experience. We test our hypotheses by studying two of the most important research funding programmes i…