Search results for "MST"
showing 10 items of 363 documents
Toxicological interactions between the mycotoxins beauvericin, deoxynivalenol and T-2 toxin in CHO-K1 cells in vitro.
2011
Abstract Beauvericin (BEA), deoxynivalenol (DON) and T-2 toxin (T-2) are important food-borne mycotoxins that have been implicated in human health. In this study, the acute toxicity of individual and combined mycotoxins (BEA, DON and T-2) were tested in immortalized hamster ovarian cells (CHO-K1) at 24, 48 and 72 h of exposure, by the tetrazolium salt (MTT) and neutral red (NR) assays. The IC50 values obtained for all mycotoxins by the MTT and NR assays ranged from 0.017 to 12.08 μM and from 0.042 to 17.22 μM, respectively. Both, individual and combined mycotoxins demonstrated a significant cytotoxic effect in CHO-K1 cells in a dose-dependent manner. When mycotoxins were assayed individuall…
Nosacīta pirmstermiņa atbrīvošana no soda
2021
Nosacīta pirmstermiņa atbrīvošanas no soda ir iespēja, kā ar brīvības atņemšanu notiesātajam izkļūt no ieslodzījuma vietas ātrāk nekā tas noteikts ar notiesājošu spriedumu. Pirms nosacītas pirmstermiņa atbrīvošanas tiek veikta padziļināta notiesātā izpēte nosacītas pirmstermiņa atbrīvošanas atbilstībai, kā arī pēc atbrīvošanas notiesātajam ir virkne pienākumu, kas viņam jāveic. Bakalaura darba mērķis ir izprast nosacītas pirmstermiņa atbrīvošanas no soda institūtu, tā attīstību Latvijā, salīdzinājumā ar citām valstīm, kā arī gūt priekšstatu par tā efektivitāti vai problēmām. Bakalaura darba uzdevumi ir izpētīt nosacītas pirmstermiņa atbrīvošanas jēdziena attīstību Latvijā, izanalizēt nosacī…
High-precision momentum measurements of projectile fragments in Sn+Sn collisions at 1·A GeV
2012
Production cross-sections and longitudinal velocity distributions of the projectilelike residues produced in peripheral and mid-peripheral reactions 112Sn + 112Sn and 124Sn + 124Sn both at an incident beam energy of 1 A GeV were measured with the high-resolution magnetic spectrometer, the Fragment Separator of GSI. For both reactions the characteristics of the velocity distributions and nuclide production cross-sections were determined for residues with nuclear charge Z 10. A comparison of the results of the two reactions is presented and the results are studied in the frame of dynamical transport calculations coupled with a statistical multifragmentation code. In mid-peripheral collisions …
A collision timing monitor for SuperKEKB
2017
Abstract The analysis of beamstrahlung radiation, emitted from a beam of charged particles due to the electromagnetic interaction with a second beam of charged particles, provides a diagnostic tool that can be used to monitor beam–beam collisions in a e + e − storage ring. In this paper we show that the beamstrahlung time profile is related to the timing of the collisions and the length of the beams, and how its measurement can be used to monitor and optimize collisions at the interaction point of the SuperKEKB collider. The method has a unique passive monitor capability, since it allows to monitor the timing of the collision without disturbing (scanning) the beam–beam timing, which needs t…
Experimental techniques for testing the sensitivity of bladder tumours to antineoplastic drugs
1973
A number of laboratory tests can be employed to examine the sensitivity of human bladder tumour cells to various chemotherapeutic agents.-Their principles and methods, and some preliminary results, are described with special reference to certain in vitro and in vivo cytotoxicity tests and to heterotransplantation in the hamster. Satisfactory agreement has sometimes been observed between experimental results and clinical responses, but our experience is still very limited.-The employment of several such tests would probably lead to a greater degree of reliability in the laboratory assessment of the sensitivity of bladder tumours to cytotoxic drugs.
The taint of torture and the brazilian legal system
2019
In Brazil, the practice of torture intertwines deeply with its own history. The literature on the subject has had a greater intensification on its registers during the Dictatorial Regime (1964 to 1985). In spite of the Brazilian Constitution of 1988, Brazil only makes efforts to investigate the crimes of torture of this period to comply with the provisions of the United Nations in 2011. Within this scenario, the NationalTruth Commission (Law 12.528, of November 2011) was created with the purpose of clarifying the facts and circumstances of cases concerning human rights violations, as well as the Law on Access to Information (Law 12.527 of November 2011), which have regulated the constitutio…
Hvordan skapes rom for «omvendt deltakelse» i bærekraftig lokal samfunnsutvikling – aksjonsforskningens roller og bevegelser
2021
Det er økende oppmerksomhet på potensialer for borgeres engasjement i bærekraftig omstilling og lokaliseringen av FNs bærekraftsmål. Flere forsknings- og policyrapporter etterlyser bedre forståelse for hvordan bærekraft kan «oversettes» og implementeres i lokal planlegging og handling. Bærekraftig samfunnsomstilling krever bedre forståelser for hvordan offentlige/kommunale systemer kan samarbeide med borgerinitiativer – samtidig som de lokale initiativene bevarer selvstendighet og lokal forankring. I denne artikkelen tar vi utgangspunkt i en aksjonsforskningsprosess med borgerinitiativer i Oslo og ByKuben, Oslo kommunes senter for byøkologi. Vi utforsker hvordan det kan skapes rom for delta…
The experimental study of the hybrid fixation in ACL reconstruction
2012
Abstract The article is approaching an interesting topic regarding ACL reconstruction using the hamstring tendons (semitendinosus and gracilis) as the graft. The initial graft fixation after ACL reconstruction is mechanical and it must assure the stability of the system until the biologic integration takes place. No fixation system is as strong as the native ACL insertion. Therefore, hibrid fixation like an improvement of simple fixation is a field worth studying. The fixation shown in this article is the Hybrid fixation consisting of direct fixation with interference screw and an extra cortical fixation over a cortical screw.
MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate
2019
Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain (PBD), which has a key regulatory function for kinase activity and substrate recognition. We report on 3-bromomethyl-benzofuran-2-carboxylic acid ethyl ester (designated: MCC1019) as selective PLK1 inhibitor targeting PLK1 PBD. Cytotoxicity and fluorescence polarization-based screening were applied to a library of 1162 drug-like compounds to identify potential inhibitors of PLK1 PBD. The activity of compound MC1019 against the PLK1…
An in vitro model to study cellular photosensitizer uptake and photodynamic dose-response relationships of tumor cells
1993
Cellular fluorescence intensity (CFI) after incubation with varying concentrations of the photosensitizer Photofrin and the photodynamically induced dose-response relationships of hamster melanoma cells (A-MEL-3) were studied in a recently developed in vitro model. After administration of Photofrin to the extracellular serum-free medium, CFI was evaluated by flow cytometry together with constantly fluorescing latex particles used as a reference. After 5 min, 50% of maximal CFI was found, and after 60 min CFI was maximal. No further increase was obtained during the exposure to Photofrin over the incubation period of 4 h. During this plateau phase, CFI was significantly related to the concent…