Search results for "MT1"

The Histone Deacetylase Inhibitor JAHA Down-Regulates pERK and Global DNA Methylation in MDA-MB231 Breast Cancer Cells

2015

The histone deacetylase inhibitor N-1-(ferrocenyl)-N-8-hydroxyoctanediamide (JAHA) down-regulates extracellular-signal-regulated kinase (ERK) and its activated form in triple-negative MDA-MB231 breast cancer cells after 18 h and up to 30 h of treatment, and to a lesser extent AKT and phospho-AKT after 30 h and up to 48 h of treatment. Also, DNA methyltransferase 1 (DNMT1), 3b and, to a lesser extent, 3a, downstream ERK targets, were down-regulated already at 18 h with an increase up to 48 h of exposure. Methylation-sensitive restriction arbitrarily-primed (MeSAP) polymerase chain reaction (PCR) analysis confirmed the ability of JAHA to induce genome-wide DNA hypomethylation at 48 h of expos…

“DNA Methyl transferase 1 post-trascriptional silencing indues aneuploidy and cell cycle arrest in human cells”,

2009

Reactivation of SNURF-SNRPN gene by DNA Methyltransferase inhibitors in a Prader-Willi lymphoblastoid cell line.

2014

Análisis del repertorio musical en los manuales escolares

2021

Una de las concreciones de la pedagogía crítica en la educación musical es la utilización de un repertorio que incorpore las preferencias del alumnado. En este estudio se aborda la presencia de dicho repertorio en los manuales escolares más utilizados en la actualidad. Para ello, se ha accedido a 15 libros de texto, analizando 985 piezas distintas. Las variables empleadas han sido el período histórico o género musical, el estilo dentro del repertorio de la música popular urbana, la antigüedad del autor y la tipología de propuesta didáctica asociada. Los resultados indican que la música popular urbana tiene una escasa presencia en los manuales (8.20%) y no coincide con las preferencias de lo…

Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells

2012

Abstract Background Aneuploidy has been acknowledged as a major source of genomic instability in cancer, and it is often considered the result of chromosome segregation errors including those caused by defects in genes controlling the mitotic spindle assembly, centrosome duplication and cell-cycle checkpoints. Aneuploidy and chromosomal instability has been also correlated with epigenetic alteration, however the molecular basis of this correlation is poorly understood. Results To address the functional connection existing between epigenetic changes and aneuploidy, we used RNA-interference to silence the DNMT1 gene, encoding for a highly conserved member of the DNA methyl-transferases. DNMT1…

R. Cremades (Coord.), D. García Gil, MªB. Lizaso Azcune, A. Morales Fernández, MªJ. Del Olmo Barros, M. Román Álvarez e I. Sustaeta Llombart (2017). …

2020

Reseña del libro de R. Cremades (Coord.), D. García Gil, MªB. Lizaso Azcune, A. Morales Fernández, MªJ. Del Olmo Barros, M. Román Álvarez e I. Sustaeta Llombart (2017). Didáctica de la Música en Educación Infantil. Madrid: Ediciones Paraninfo.

Overespression of MT1-MMP modified the integrity of endothelial cell contact

2009

Homology models of melatonin receptors: challenges and recent advances

2013

Melatonin exerts many of its actions through the activation of two G protein-coupled receptors (GPCRs), named MT1 and MT2. So far, a number of different MT1 and MT2 receptor homology models, built either from the prototypic structure of rhodopsin or from recently solved X-ray structures of druggable GPCRs, have been proposed. These receptor models differ in the binding modes hypothesized for melatonin and melatonergic ligands, with distinct patterns of ligand-receptor interactions and putative bioactive conformations of ligands. The receptor models will be described, and they will be discussed in light of the available information from mutagenesis experiments and ligand-based pharmacophore …

Excess of de novo variants in genes involved in chromatin remodelling in patients with marfanoid habitus and intellectual disability.

2020

PurposeMarfanoid habitus (MH) combined with intellectual disability (ID) (MHID) is a clinically and genetically heterogeneous presentation. The combination of array CGH and targeted sequencing of genes responsible for Marfan or Lujan–Fryns syndrome explain no more than 20% of subjects.MethodsTo further decipher the genetic basis of MHID, we performed exome sequencing on a combination of trio-based (33 subjects) or single probands (31 subjects), of which 61 were sporadic.ResultsWe identified eight genes with de novo variants (DNVs) in at least two unrelated individuals (ARID1B, ATP1A1, DLG4, EHMT1, NFIX, NSD1, NUP205 and ZEB2). Using simulation models, we showed that five genes (DLG4, NFIX, …

Estudio comparativo de dos metodologías aplicadas para la comprensión de la música contemporánea en la educación secundaria obligatoria

2016

In this paper we try to discover which methodology is more appropriate for the comprehension of the contemporary music in the Secondary Education. For that purpose by a quasi-experiment, mixed, qualitative and quantitative, the preserved results through the application of two different methodologies have been compared: a traditional one base on the masterly class and another based in different kinds of audition. The obtained results after the didactical application on the quantitative level weren´t significant, however, on the qualitative level we could also observe that the pupils who subjected to that methodology had more advantageous results regarding to the comprehension of the contempo…