Search results for "MT"

Alemtuzumab Plus Oral Dexamethasone, Followed by Alemtuzumab Maintenance or Allogeneic Transplantation in Ultra High-Risk CLL: Updated Results From a…

2012

Abstract Abstract 716 CLL patients characterized by 17p-, TP53 mutation or refractoriness to fludarabine (F)-based therapy show a very poor prognosis (“ultra high-risk CLL”). Although alemtuzumab (A) showed efficacy in these cohorts, the rate and duration of remissions remain unsatisfactory. Aim of the CLL2O study was to achieve higher overall response rates (ORR) by adding high-dose dexamethasone (D) to A during induction and investigating the consolidation effect of prolonged A or allogeneic stem-cell transplantation (allo-SCT), respectively. Induction treatment consisted of subcutaneous A, 30 mg weekly × 3 for 28 days, combined with oral D, 40 mg on days 1–4 and 15–18, and prophylactic p…

Unraveling materials Berry curvature and Chern numbers from real-time evolution of Bloch states

2019

Materials can be classified by the topological character of their electronic structure and, in this perspective, global attributes immune to local deformations have been discussed in terms of Berry curvature and Chern numbers. Except for instructional simple models, linear response theories have been ubiquitously employed in calculations of topological properties of real materials. Here we propose a completely different and versatile approach to get the topological characteristics of materials by calculating physical observables from the real-time evolving Bloch states: the cell-averaged current density reveals the anomalous velocities whose integration leads to the conductivity quantum. Re…

Biphasic Erk1/2 activation sequentially involving Gs and Gi signaling is required in beta3-adrenergic receptor-induced primary smooth muscle cell pro…

2013

Abstract The beta3 adrenergic receptor (B3-AR) reportedly induces cell proliferation, but the signaling pathways that were proposed, involving either Gs or Gi coupling, remain controversial. To further investigate the role of G protein coupling in B3-AR induced proliferation, we stimulated primary human myometrial smooth muscle cells with SAR150640 (B3-AR agonist) in the absence or presence of variable G-protein inhibitors. Specific B3-AR stimulation led to an Erk1/2 induced proliferation. We observed that the proliferative effects of B3-AR require two Erk1/2 activation peaks (the first after 3 min, the second at 8 h). Erk1/2 activation at 3 min was mimicked by forskolin (adenylyl-cyclase a…

Vairogdziedzera mezglu analizēšana, izmantojot attēlu diagnostikas klasifikācijas un datu sistēmu (TIRADS), un salīdzinot ar Bethesda sistēmu

2017

Vairogdziedzera attēlu diagnostikas klasifikācijas un datu sistēma (Thyroid Imaging Reporting and Data System, TIRADS) ir klasifikācijas sistēma, kas iedala mezglu malignitātes riskus. Katra kategorija reprezentē vairogdziedzera mezgla malignitātes risku. Tā izveidota ar mērķi uzlabot reaģēšanu un izmaksu pārvaldību, samazinot vajadzību pēc ar tievu adatu aspirācijas biopsijas pacientiem, kuriem ir vairogdziedzera mezgli. TIRADS sistēma ir riska novērtēšanas sistēma vairogdziedzera audu bojājumu klasificēšanai. TIRADS novērtējums sniedz informāciju par vairogdziedzera struktūru, malignitātes risku un klasifikāciju. Bethesda sistēma vairogdziedzera citopatoloģiju novērtēšanai ir vairogdziedz…

Synergistic antiangiogenic activity of bexarotene in combination with rosuvastatin by targeting ang-ii-mediated akt/mtor/p70s6k signaling pathway

2014

Bezpajumtnieku dzīves telpa un ikdienas prakses Maskavas forštatē

2016

Bezpajumtnieki ir mūsdienu pilsētu sastāvdaļa, kur viņu darbības un dzīvesveids iespaido pilsētu ainavu, tāpēc ir nepieciešams izvērtēt viņu dzīves telpu un ikdienas prakses, lai spētu novērtēt šo ietekmi. Kā pētījuma vieta tika izvēlēta Rīgas pilsētas Maskavas forštates apkaime, kur ikdienā bieži var sastapt bezpajumtniekus. Lai sasniegtu izvirzīto mērķi, tika uzstādīti 4 uzdevumi un 3 jautājumi uz, kuriem pētījuma laikā tika rasta atbilde. Darbā tika pielietotas sekojošās metodes: (1) zinātniskās literatūras apkopošana; (2) plašsaziņas līdzekļu satura analīze; (3) novērojumi; (4) daļēji strukturētas intervijas un (5) līdziešanas metode. Pielietojot pētījuma metodes, tika iegūti rezultāti,…

Spin qubits with electrically gated polyoxometalate molecules

2007

Spin qubits offer one of the most promising routes to the implementation of quantum computers. Very recent results in semiconductor quantum dots show that electrically-controlled gating schemes are particularly well-suited for the realization of a universal set of quantum logical gates. Scalability to a larger number of qubits, however, remains an issue for such semiconductor quantum dots. In contrast, a chemical bottom-up approach allows one to produce identical units in which localized spins represent the qubits. Molecular magnetism has produced a wide range of systems with tailored properties, but molecules permitting electrical gating have been lacking. Here we propose to use the polyox…

Design and computer simulations of 2D MeX2 solid-state nanopores for DNA and protein detection analysis

2020

Solid-state nanopores (SSN) have emerged as versatile devices for biomolecule analysis. One of the most promising applications of SSN is DNA and protein sequencing, at a low cost and faster than the current standard methods. SSN sequencing is based on the measurement of ionic current variations when a biomolecule embedded in electrolyte is driven through a nanopore under an applied electric potential. As a biomolecule translocates through the nanopore, it occupies the pore volume and blocks the passage of ions. Hence, ultrafast monitoring of ionic flow during the passage of a biomolecule yields information about its structure and chemical properties. The size of the sensing region in SSN is…

Mazā ērgļa Aquila pomarina C.L. Brehm taksonomija, izplatība, skaits un ekoloģija Latvijā

1999

Advisor: Vīksne, Jānis

Polarization Modulation Instability in All-Normal Dispersion Microstructured Optical Fibers with Quasi-Continuous 1064 nm Pump

2019

Polarization modulation instability (PMI) is a form of modulation instability that can exist in weakly birefringent optical fibers [1]. Sidebands can be generated by this effect when a polarization mode of the birefringent fiber is excited with an intense optical pump. The polarization state of the sidebands is orthogonal to the polarization of the pump signal. PMI has been observed in microstructured optical fibers (MOFs). PMI was reported in a large-air-filling fraction MOF that was pumped in the normal dispersion regime with visible light [2]. The coherent degradation of femtosecond supercontinuum light generated in all-normal dispersion (ANDi) MOFs due to PMI was recently investigated […