Search results for "MT"

Dissipation of post-pulse laser-induced alignment of CO2through collisions with Ar

2015

In this paper, laser-induced field-free alignment of CO2 in mixtures with Ar is investigated under dissipative conditions (up to 15 bars) at room temperature. The degree of alignment is temporally monitored by a polarization spectroscopy technique, where a weak probe pulse measures the transient birefringence resulting from the alignment. The data are analyzed with a quantum mechanical density matrix formalism using properly J-dependent and M-dependent state-to-state transfer rates, which was previously successfully tested on pure CO2 and CO2–He mixtures. The same consistency is obtained between experiments and calculations, in particular the decay times of both the transient revivals and t…

Les appellations d'origine en héritage : une AOP se transmet-elle ? Le cas des appellations d'origine fromagères franc-comtoises

2022

Les appellations d’origine fromagères de la Franche-Comté possèdent une renommée en partie basée sur une histoire longue et des pratiques transmises par les générations successives. Mais outre la transmission des moyens de production, et la succession des activités d’agriculteur, de fromager et d’affineur, y a-t-il en plus une transmission de l’AOP elle-même ?

Le Bleu de Gex, une petite production pour un grand fromage

2001

Le fromage le plus connu du massif jurassien est bien sûr le Comté, avec ses 46 000 tonnes de production. sa présence sur l'ensemble du massif, sa commercialisation à large échelle. Nous parlerons ici d'un autre fromage fabriqué en Franche-Comté et qui fait un peu figure de lilliputien : la production annuelle de Bleu de Gex. appelé aussi Bleu du Haut-Jura ou Bleu de Septmoncel. se situe en effet depuis 25 ans entre 500 et 600 tonnes. Il s'agit de la plus petite AOC fromagère au lait de vache en France !

Chronological Age Interacts with the Circadian Melatonin Receptor 1B Gene Variation, Determining Fasting Glucose Concentrations in Mediterranean Popu…

2020

Gene-age interactions have not been systematically investigated on metabolic phenotypes and this modulation will be key for a better understanding of the temporal regulation in nutrigenomics. Taking into account that aging is typically associated with both impairment of the circadian system and a decrease in melatonin secretion, we focused on the melatonin receptor 1B (MTNR1B)-rs10830963 C&gt

ENDOCRINE SIDE EFFECTS OF ANTI-CANCER DRUGS: Effects of anti-cancer targeted therapies on lipid and glucose metabolism

2014

During the past years, targeted therapies for cancer have been developed using drugs that have significant metabolic consequences. Among them, the mammalian target of rapamycin (mTOR) inhibitors and, to a much lesser extent, the tyrosine kinase inhibitors (TKIs) are involved. mTOR plays a key role in the regulation of cell growth as well as lipid and glucose metabolism. Treatment with mTOR inhibitors is associated with a significant increase in plasma triglycerides and LDL cholesterol. mTOR inhibitors seem to increase plasma triglycerides by reducing the activity of the lipoprotein lipase which is in charge of the catabolism of triglyceride-rich lipoproteins. The increase in LDL cholesterol…

Gene Expression Profiling of Epithelial–Mesenchymal Transition in Primary Breast Cancer Cell Culture

2014

Background/Aim: Epithelial–mesenchymal transition (EMT) is a process co-opted by cancer cells to invade and form metastases. In the present study we analyzed gene expression profiles of primary breast cancer cells in culture in order to highlight genes related to EMT. Materials and Methods: Microarray expression analysis of primary cells isolated from a specimen of a patient with an infiltrating ductal carcinoma of the breast was performed. Real-Time Quantitative Reverse Transcription PCR (qRT-PCR) analyses validated microarray gene expression trends. Results: Thirty-six candidate genes were selected and used to generate a molecular network displaying the tight relationship among them. The …

Different modulatory effect of the synthetic cannabinoid WIN55,212-2 on tumor cell migration.

2015

MicroRNAs are small non-coding regulatory molecules exerting pleiotropic action in different biological processes such as proliferation, differentiation, apoptosis, migration and metastasis. Deregulation of miRNA expression has been observed in various cancers, and accumulating data suggest that miRNAs can display an oncogenic, antioncogenic or an ambiguous behavior in relationship to tumor environment. In a previous research we showed that the synthetic cannabinoid WIN55,212-2 is able to reduce the migratory activity of osteosarcoma MG63 cells analyzed by means of wound healing assay. So we undertook a study to evaluate the biochemical mechanism through which WIN plays this action. To this…

336P PI3K pathway biomarkers and clinical response in a phase I/Ib study of GDC-0077 in hormone receptor-positive/HER2-negative breast cancer (HR+/HE…

2020

Incidence of oncogenes in PI3K/AKT and MAPK signaling pathways in breast cancer

2015

Personalized multimedia touristic services for hybrid broadcast/broadband mobile receivers

2010

This paper presents the topology of a multimedia tourism service that targets mobile devices equipped with broadband and either multicast or broadcast access capabilities. Multicast / Broadcast access is used to handle the delivery of multimedia data to many simultaneous users in the service area. The solution adopted is based on existing standards for mobile TV services, but introducing features that enable the provision of generic multimedia services on top of mobile hybrid broadband and broadcast networks. Furthermore, this paper shows how to use standardized interfaces originally defined for interactive mobile TV broadcasting to build personalized mobile multimedia services that do not …