Search results for "MULTIPLE"
showing 10 items of 2678 documents
Differential Gene Expression of Medullary Thyroid Carcinoma Reveals Specific Markers Associated with Genetic Conditions
2013
Maliszewska, Agnieszka et al.
Medullary Thyroid Carcinoma With Exon 2 p.L56M RET Variant: Clinical Particular Features in Two Patients
2018
RET (REarranged during Transfection) proto-oncogene variants are essential for the development of familial and sporadic forms of medullary thyroid carcinoma (MTC). The most frequent variants are usually located in exons 10, 11, and 13 through 16 of the RET gene. We report two cases of apparently sporadic MTC associated with the variant in exon 2 of RET gene. Patient 1, a 62-year old man who had undergone adrenalectomy for a 5 cm pheochromocytoma, was screened for type 2 multiple endocrine neoplasia (MEN 2) which showed elevated basal and post-intravenous calcium gluconate calcitonin levels. A fine needle aspiration biopsy (FNAB) confirmed the suspicion of MTC. The patient underwent total th…
What is the relationship between chronic cerebrospinal venous insufficiency and multiple sclerosis?
2013
Abstract Although most of the research on multiple sclerosis was focused on its autoimmune aspects, researchers were also considering the roles of other factors, including vascular background of the disease. The idea that multiple sclerosis might be caused by stenoses of the veins draining the brain and spinal cord (the so-called chronic cerebrospinal venous insufficiency), is currently hotly debated by scientific community. Despite conflicting reports, chronic cerebrospinal venous insufficiency seems to be a real clinical phenomenon. However, it remains uncertain how it should be defined and which tests should be used for its detection. Probably this vascular abnormality should be primaril…
Four cases of progressive multifocal leukoencephalopathy in iatrogenic immunocompromised patients
2020
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) caused by John Cunningham Virus (JCV). We report four PML cases in immunocompromised patients, respectively treated with (1) Natalizumab, (2) Rituximab, (3) autologous stem-cell transplantation, and (4) Tacrolimus. All patients underwent neurological examination, magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), JCV-DNA research on biological samples, and lymphocytes subpopulation study. All cases presented with motor, behavioural, and cognitive disorders. Visual, sensitive, and cerebellar deficits developed in three cases. MRI revealed widespread progressiv…
Fingolimod (FTY720-P) Does Not Stabilize the Blood–Brain Barrier under Inflammatory Conditions in an in Vitro Model
2015
Breakdown of the blood-brain barrier (BBB) is an early hallmark of multiple sclerosis (MS), a progressive inflammatory disease of the central nervous system. Cell adhesion in the BBB is modulated by sphingosine-1-phosphate (S1P), a signaling protein, via S1P receptors (S1P\(_1\)). Fingolimod phosphate (FTY720-P) a functional S1P\(_1\) antagonist has been shown to improve the relapse rate in relapsing-remitting MS by preventing the egress of lymphocytes from lymph nodes. However, its role in modulating BBB permeabilityin particular, on the tight junction proteins occludin, claudin 5 and ZO-1has not been well elucidated to date. In the present study, FTY720-P did not change the transendotheli…
EDUCAREACOMPRENDERE IN UNACOMUNITÀ DI RICERCA L'EVOLVERSI DELLA TEORIA DIHOWARD GARDNER PER UNA VALIDA FILOSOFIA DI RIFORMA DELL’AGIRE FORMATIVO, ATT…
2013
Mācību metožu izvēle matemātikā 10. klasei, balstoties H.Gārdnera daudzveidīgo inteliģenču teorijā
2014
Bakalaura darba tēma ir „Mācību metožu izvēle matemātikā 10. klasei, balstoties H. Gārdnera daudzveidīgo inteliģenču teorijā”. Teorētiskajā daļā apkopotas mācību metodes atbilstoši 7 inteliģencēm, bet pētnieciskajā daļā tās ir iekļautas mācību procesā ar mērķi pārbaudīt to labvēlīgo ietekmi uz mācību sasniegumu uzlabošanos. Darbs sastāv no 3 nodaļām – teorētiskā apskata, metodoloģijas un pētījuma daļas. Tajā iekļautas 9 tabulas, 12 attēli, 17 literatūras avoti.
Daudzveidīgo spēju teorija angļu valodas vārdu krājuma apguves veicināšanai 5. klasē
2017
Diplomdarbā autore aplūko daudzveidīgo spēju teoriju angļu valodas vārdu krājuma apguves veicināšanai stundās pamatskolā. Angļu valodas vārdu krājuma apguve tiek uzskatīta par skolēnu galveno izaicinājumu. Ņemot vērā, ka katram skolēnam piemīt savs mācīšanās veids, ikviens izprot pasauli un uzlabo valodas prasmes savādāk, tika sagatavoti dažādi jauno vārdu prezentēšanas un praktizēšanas uzdevumi, kas balstīti uz daudzveidīgo spēju teoriju. Diplomdarba mērķis ir izpētīt, kā daudzveidīgo spēju teorija var tikt izmantota angļu valodas vārdu krājuma apguves veicināšanā 5.klasē. Lai sasniegtu Diplomdarbā izvirzīto mērķi, tika veikts teorētiskās literatūras apkopojums un, kā pētniecības metode, t…
Correlation between neonatal outcomes of twins depends on the outcome : Secondary analysis of twelve randomised controlled trials
2018
ObjectiveTo estimate the magnitude of the correlation between neonatal outcomes of twins and demonstrate how this information can be used in the design of randomised controlled trials (RCTs) in women with twin pregnancies.DesignSecondary analysis of data from 12 RCTs.SettingObstetric care in multiple countries, 2004-2012.Population or sample4504 twin pairs born to women who participated in RCTs to assess treatments given during pregnancy.MethodsIntraclass correlation coefficients (ICCs) were estimated using log-binomial and linear models.Main outcome measuresPerinatal death, respiratory distress syndrome, bronchopulmonary dysplasia, intraventricular haemorrhage, necrotising enterocolitis, s…
Patient with Kabuki syndrome and acute leukemia
2003
Kabuki syndrome is a multiple congenital anomaly/mental retardation syndrome which often involves recurrent infections. There is cumulative evidence of an immunodeficiency in Kabuki patients. We report a 2-year-old girl with typical Kabuki syndrome, who developed acute lymphocytic leukemia. The patient showed low levels of immunoglobulins G and A and a history of recurrent infections, that might indicate an immunodeficiency leading to an increased susceptibility to cancer. The girl was treated according to BFM protocols adapted to the patient's impaired cardiac situation and severe underweight. She achieved continual complete remission. Classical and molecular cytogenetic analyzes did not d…