Search results for "MVA"
showing 10 items of 89 documents
Anti-inflammatory properties of simvastatin on leukocyte-endothelial cell interactions following hemorrhagic shock
2002
Background Hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have been shown to lower serum cholesterol levels. Recent studies reported that statins have vasculoprotective effects independent of their cholesterol-lowering properties. We studied simvastatin for its ability to modulate leukocyte-endothelial cell interactions under acute inflammation following hemorrhage and reperfusion. Methods The effects of simvastatin on leukocyte-endothelial cell interactions were observed by intravital microscopy in the rat mesenteric microcirculation and by immunohistochemical analyzes. Simvastatin (50 μg/kg or 100 μg/kg) was administrated intraperitoneally 18 h before study. Inf…
New Forms of Work in the Light of Globalization in Software Development
2009
Globalization in software development introduced significant changes in the way organizations operate today. Software is nowadays produced by team members from geographically, temporally and culturally remote sites. Organizations seek for benefits that global market offers and face new challenges. Naturally resistant to change, these organizations often do not realize necessity for tailoring existing methods for distributed collaboration. Our empirical investigation shows a great variety in the ways organizations distribute responsibilities across remote sites and conclude that these can be divided into two main categories: joint collaboration that requires investments in team building and …
Ezetimibe with or without simvastatin increases small dense low-density lipoproteins in healthy men – a randomized trial
2010
Critical comments on EEG sensor space dynamical connectivity analysis
2019
Many different analysis techniques have been developed and applied to EEG recordings that allow one to investigate how different brain areas interact. One particular class of methods, based on the linear parametric representation of multiple interacting time series, is widely used to study causal connectivity in the brain. However, the results obtained by these methods should be interpreted with great care. The goal of this paper is to show, both theoretically and using simulations, that results obtained by applying causal connectivity measures on the sensor (scalp) time series do not allow interpretation in terms of interacting brain sources. This is because (1) the channel locations canno…
Poliprenolu iedarbība un to ietekme uz atorvastatīna efektiem WISTAR līnijas žurkām uzvedības, atmiņas un analgēzijas testos
2015
Poliprenoli (PP) ir izdalīti no augiem, tai skaitā, no skujkokiem. To ietekme uz centrālās nervu sistēmas (CNS) procesiem ir ļoti maz pētīta. Ir zināms, ka gan PP, gan holesterols un doliholi veidojas caur mevalonskābes atkarīgiem ceļiem (MVA) ar 3-hidroksi-3-metilglutaril-koenzīma A reduktāzes palīdzību. Šo enzīmu inhibē holesterola biosintēzes inhibītori statīni, kuru ilgstoša lietošana slimniekiem nelabvēlīgi ietekmē kognitīvās funkcijas (Schilling et al., 2014). Darba mērķis bija noteikt PP, atorvastatīna (AT), kā arī to kombinācijas ietekmi uz izmēģinājuma dzīvnieku (žurku) vispārējo aktivitāti, atmiņas procesiem un sāpju slieksni. Iegūtie dati liecina, ka AT piemīt pretsāpju iedarbība…
Effect of simvastatin on desaturase activities in liver from lean and obese zucker rats
1993
The effect of simvastatin, a hypocholesterolemic drug, on the biosynthesis of arachidonic acid was studied in obese and lean Zucker rats. After administration of 2 mg/kg body weight/d for 13 d, delta 6 and delta 5 desaturase activities were measured in liver microsomes at two substrate concentrations. In untreated rats, the delta 6 desaturation rate was similar in the obese and lean rats when measured at saturating substrate levels, whereas delta 5 desaturation was lower in the obese animals. Treatment with simvastatin did not change delta 6 desaturation in either phenotype but increased delta 5 desaturation in obese rats to reach the unchanged rate observed in lean animals. The changes wer…
Plasma clearance of human low-density lipoprotein in human apolipoprotein B transgenic mice is related to particle diameter.
2004
To test for intrinsic differences in metabolic properties of low-density lipoprotein (LDL) as a function of particle size, we examined the kinetic behavior of 6 human LDL fractions ranging in size from 251 to 265 A injected intravenously into human apolipoprotein (apo) B transgenic mice. A multicompartmental model was formulated and fitted to the data by standard nonlinear regression using the Simulation, Analysis and Modeling (SAAM II) program. Smaller sized LDL particles (251 to 257 A) demonstrated a significantly slower fractional catabolic rate (FCR) (0.050 +/- 0.045 h(-1)) compared with particles of larger size (262 to 265 A) (0.134 +/- -0.015 h(-1), P.03), and there was a significant …
Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activatio…
1999
To test the Kirsten-Ras (Ki-Ras) alternative prenylation hypothesis in malignant transformation, we used a novel farnesyltransferase inhibitor competitive to farnesyl-pyrophosphate, RPR130401, and a CaaX peptidomimetic geranylgeranyltransferase-1 inhibitor GGTI-298. In Ki-Ras-overexpressing transformed adrenocortical cells, RPR130401 at 1-10 microM inhibited very efficiently the [(3)H]farnesyl but not [(3)H]geranylgeranyl transfer to Ras. However, proliferation of these cells was only slightly sensitive to RPR130401 (IC(50)=30 microM). GGTI-298 inhibited the growth of these cells with an IC(50) of 11 microM but cell lysis was observed at 15 microM. The combination of 10 microM RPR130401 and…
Piecdesmit sestās zinātniskās konferences Bibliotēkzinātnes sekcija (1997.gada 24.septembris): tēzes
1997
Saturs: 1. Akadēmiskā bibliotēka un lasītājs: tagadne un nākotne 2. Bibliotekārā psiholoģija 3. Bibliogrāfija kā darbība un līdzekļi (Ieskats rietumvalstu bibliogrāfijas teorētiķu publikācijās) 4. Bibliotēka informācijas sabiedrībā 5. Informācijas meklējumvalodas informācijas meklēšanā 6. Informācijas meklējumvalodu uzbūve un lietošanas problēmas datorkatalogā 7 Ārzemju profesori LU 20. 30. gados 8. Kārlis Rasiņš (1886 - 1974) un apgāds "Literatūra"
Bibliotēka un sabiedrība, 3
2002
Krājumā ievietoti raksti, kuros aplūkoti jauni virzieni informācijas izplatībā un bibliotēku darbībā, kā arī informācijas sakārtošanā un apstrādē. Atsevišķos rakstos analizētas vēsturiskas parādības. Raksti izkārtoti četrās tematiskās iedaļās: "Grāmata vērtību sistēmā", "Bibliotēku vēstures pētījumi", "Publiskās bibliotēkas mūsdienu sabiedrībā" un "Informācijas avotu apstrādes problēmas".