Search results for "Mace"
showing 10 items of 4713 documents
Políticas culturales y nuevas tecnologías
2019
espanolEl siguiente ensayo tiene como proposito explorar la conformacion de tres blogs literarios y uno perteneciente al mundo del arte a la luz del concepto de politica cultural sostenido por el antropologo y filosofo argentino Nestor Garcia Canclini. Analizaremos en que consisten cada uno de ellos, veremos que practicas culturales instituyen en relacion a practicas y saberes previos; como otorgan visibilidad a nuevos actores sociales; de que manera generan vinculos nuevos en relacion a la produccion, la circulacion y la recepcion del arte y la literatura; desde que concepcion de la cultura trabajan; que aspectos podrian tomar para replicar otras instituciones ya sean publicas, privadas o …
Citizen Coherence and Cultivated Cleanliness: Using Technology-Induced Social Norms to Strengthen Sustainable Household Bonds
2022
Social identity and social capital are critical to human well-being and sustainable development. However, existing research on sustainable behavior typically treats these factors merely as taken-for-granted preconditions to environmental protection. This paper argues that they can also be direct outcomes of environment-oriented efforts, thus becoming drivers of sustainable societies. As part of a larger research project on household recycling and waste behavior, the authors assess and compare perceived social identity and social capital of residents in a multi-family residential dwelling in Sweden before (N = 66) and after (N = 18) exposure to a social norm-based intervention delivered thro…
Polski eurosceptycyzm w kontekście dylematów teoretycznych i porównawczych
2015
Polish Euroscepticism in the context of theoretical and comparative dilemmas The aim of this article is an analysis of two of the most inflammatory issues in the debate over Euroscepticism – the typology of anti‑European attitudes and the main conditioning factors of these attitudes. The first aspect constitutes a certain substitute for a definitional debate, since despite the abundance of studies related to Euroscepticism, such studies contain only trace definitional concepts. In the Polish perspective, the two issues above have been presented in the context of the specificity of Poland’s political scene in the 1990s and early 2000s. This confirms that Euroscepticism is a phenomenon that e…
Apresentação
2018
L'articolo confronta il sistema educativo 0-6 italiano e brasiliano, alla luce delle nuove normative e dell'idea di qualità educativa sottostante. Presenta successivamente,in termini critici e riflessivi, gli articoli contenuti nel numero monografico sulla "Valutazione di contesto", di ricercatori italiani e brasiliani, ricavando una sintesi che problematizza e apre nuove prospettive The article compares Italian and Brazilian 0-6 education system, considering the new laws and the underlying idea of educational quality. It then presents, in critical and reflective terms, the papers in the monographic issue on "Educational Evaluation", from Italian and Brazilian researchers, obtaining a synth…
Hepatotoxicity of systemic therapies for unresectable hepatocellular carcinoma
2021
Manifiesto de Niños, o la escenificación de la violencia
2019
espanolSin lugar a dudas con Manifiesto de Ninos, el colectivo teatral El periferico de Objetos redobla su apuesta en lo que viene siendo una propuesta estetica altamente arriesgada al ofrecernos algo asi como una “instalacion teatral de la violencia” mediante la utilizacion recrudecida del impacto emocional sobre el espectador. La obra fuerza hasta limites insospechados la tolerancia visual del receptor y plantea la anatomia de una claustrofobica experimental que intenta denunciar la violencia ejercida sobre los ninos. Los resultados de esta experiencia invocan hacia una reflexion sobre una poetica que explora la profunda abyeccion de la pulsion escopica del espectador mediante una organiz…
Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics
2021
To date, computational approaches have been recognized as a key component in drug design and discovery workflows. Developed to help researchers save time and reduce costs, several computational tools have been developed and implemented in the last twenty years. At present, they are routinely used to identify a therapeutic target, understand ligand–protein and protein–protein interactions, and identify orthosteric and allosteric binding sites, but their primary use remains the identification of hits through ligand-based and structure-based virtual screening and the optimization of lead compounds, followed by the estimation of the binding free energy. The repurposing of an old drug for the tr…
Structure‐Activity Relationships of Benzamides and Isoindolines Designed as SARS‐CoV Protease Inhibitors Effective against SARS‐CoV‐2
2020
Abstract Inhibition of coronavirus (CoV)‐encoded papain‐like cysteine proteases (PLpro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure‐activity relationships (SAR) of the noncovalent active‐site directed inhibitor (R)‐5‐amino‐2‐methyl‐N‐(1‐(naphthalen‐1‐yl)ethyl) benzamide (2 b), which is known to bind into the S3 and S4 pockets of the SARS‐CoV PLpro. Moreover, we report the discovery of isoindolines as a new class of potent PLpro inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS‐CoV‐2 replication in …
New Anti-Neoplastics Obtained by a Molecular Connectivity Method
2000
Molecular Connectivity is a method, which allows to discriminate different pharmacological activities on the basics of numeric parameters of the molecules in study, related with specific and exclusive indexes. In the present study, we propose two potentially anti-neoplasic compounds: tricromil and zomepirac, by analyzing more than a hundred different chemicals.
Sample Preparation to Determine Pharmaceutical and Personal Care Products in an All-Water Matrix: Solid Phase Extraction
2020
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