Search results for "Mace"
showing 10 items of 4713 documents
Pharmaceutical promotion and guided-prescription in low- and middle-income countries: A need for new regulations.
2020
Development and optimization of confirmatory liquid chromatography—Orbitrap mass spectrometry method for the determination of 17 anticoccidials in po…
2018
A new sensitive and selective multi-residue method based on liquid chromatography - Orbitrap high resolution mass spectrometry (LC-Orbitrap-HRMS) was developed and validated for the determination of 17 anticoccidials in poultry and eggs. Instrumental parameters were optimized by the means of statistical experimental designs to improve the sensitivity, precision, and repeatability of the method. Further optimization of auto-tuned MS parameters led to an increase of signal intensity by 10% to 99% for 16 out of 17 analytes. The sample preparation procedure included extraction from muscle tissue and egg samples with acetonitrile, followed by preconcentration, reconstitution, and filtration. Val…
Latvijas farmaceitu un farmācijas speciālistu viedoklis par papildpakalpojumu lomu farmaceitiskajā aprūpē
2020
Farmaceitiskā aprūpe balstās uz attiecībām starp pacientu un veselības aprūpes sniedzējiem, kuri uzņemas atbildību par pacienta aprūpes nodrošināšanu. Farmaceitiskā aprūpe nozīmē gan pacienta, gan veselības aprūpes sniedzēja aktīvu līdzdalību lēmumu pieņemšanā par zāļu terapiju. Farmaceitiskā aprūpe ietver medikamentu izsniegšanu, nodrošina informāciju par zālēm, pacientu konsultēšanu, zāļu uzraudzību, zāļu blakusparādību uzraudzību un zāļu saskaņošanu. Mūsdienās arvien biežāk ir sastopami dažādi papildus pakalpojumi, ko aptiekas piedāvā saviem pacientiem, ar mērķi piesaistīt klientus un veicināt pacienta-farmaceita attiecību uzlabošanu, kā arī nodrošināt maksimāli kvalitatīvu pacientu vaja…
Ekstemporālās receptūras aktualitāte mazpilsētas aptiekā
2020
Latvijā ne tikai lielajās pilsētās ārsti izraksta ekstemporālās zāļu formas, bet arī mazpilsētās, kurās notiek zāļu gatavošana aptiekās. Visbiežākais iemesls, kāpēc ārsti izraksta aptiekā izgatavojamās zāļu formas ir, lai varētu konkrētam pacientam izrakstīt vispiemērotākās un efektīvākās zāles attiecīgajai ārstēšanai. Darba mērķis bija apkopot, izanalizēt un aprakstīt gada griezumā ekstemporālo zāļu formu apriti un izrakstīšanas tendences atkarībā pēc ārsta specialitātes, pacienta vecuma un dzimuma, kā arī uzzināt farmaceitu un pacientu viedokli par ekstemporālo receptūru. Noskaidrots, ka 2019.gadā 209 receptēs bija izrakstītas 6 dažādas zāļu formas no 7 dažādu specialitāšu ārstiem. Piepra…
Similarities and differences between crystal and enzyme environmental effects on the electron density of drug molecules
2021
Abstract The crystal interaction density is generally assumed to be a suitable measure of the polarization of a low‐molecular weight ligand inside an enzyme, but this approximation has seldomly been tested and has never been quantified before. In this study, we compare the crystal interaction density and the interaction electrostatic potential for a model compound of loxistatin acid (E64c) with those inside cathepsin B, in solution, and in vacuum. We apply QM/MM calculations and experimental quantum crystallography to show that the crystal interaction density is indeed very similar to the enzyme interaction density. Less than 0.1 e are shifted between these two environments in total. Howeve…
Molecular Electron Density Theory: A Modern View of Reactivity in Organic Chemistry
2016
A new theory for the study of the reactivity in Organic Chemistry, named Molecular Electron Density Theory (MEDT), is proposed herein. MEDT is based on the idea that while the electron density distribution at the ground state is responsible for physical and chemical molecular properties, as proposed by the Density Functional Theory (DFT), the capability for changes in electron density is responsible for molecular reactivity. Within MEDT, the reactivity in Organic Chemistry is studied through a rigorous quantum chemical analysis of the changes of the electron density as well as the energies associated with these changes along the reaction path in order to understand experimental outcomes. St…
First Reactions of 2,2′-Bisindolyls with Electrophilic Azo Compounds and Diethyl Mesoxalate
1992
Conformations and some electronic properties of the 2,2′-bisindolyls 6 were calculated for the prediction of probable Diels-Alder reactivity, in analogy to previous work on 2-vinylindoles. First reactions with dienophiles revealed that compounds 6 did not participate in [4 + 2]cycloadditions but rather underwent simple electrophilic substitutions at the enamine function with, above all, some heterodienophiles. Erste Reaktionen von 2,2′-Bisindolylen mit elektrophilen Azoverbindungen und Diethylmesoxalat Zur Vorhersage moglicher Diels-Alder-Reaktionen an 2,2′-Bisindolylen 6 werden Berechnungen zur Konformation und uber elektronische Eigenschaften durchgefuhrt. Die erstmals durchgefuhrten Reak…
Stability of PEI–DNA and DOTAP–DNA complexes: effect of alkaline pH, heparin and serum
2001
Abstract DNA complexes formed with nonviral vectors such as polyethylenimine (PEI) or 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) are widely used in gene therapy. These complexes prevent the interaction of DNA with the fluorescent probes usually employed to quantify DNA. We thus studied the procedures for DNA quantification from DNA complexes as well as their stability in the presence of DNase or mouse, rat and human sera. Release of the DNA from its complexes was accomplished by increasing the pH of the medium (from 7.3 to 13.4) or by adding heparin. The stability against degradation was tested in vitro, by incubating the complexes at 37°C in the presence of DNase I and sera from the …
An allergen-polymeric nanoaggregate as a new tool for allergy vaccination.
2014
Parietaria pollen is one of the major causes of allergic reaction in southern Europe, affecting about 30% of all allergic patients in this area. Specifi immunotherapy is the only treatment able to modify the natural outcome of the disease by restoring a normal immunity against allergens. The preparation of allergen-solid lipid nanoparticles as delivery vehicles for therapeutic proteins, P. judaica major allergen Par j 2, was investigated. The Par j 2 allergen was expressed in a large amount in Escherichia coli and purifid to homogeneity. Its immunological properties were studied by western blotting and enzyme-linked immunosorbent assay inhibition. Solid lipid nanoparticles were obtained by …
Investigation of Different Iontophoretic Currents Profiles for Short-Term Applications in Cosmetics.
2018
[EN] This study aimed at investigating the effect of electrical current profile upon the iontophoretic transport of (i) ascorbic acid (AA) and (ii) ellagic acid (EA), into porcine skin in vitro, and the impact of the physicochemical properties of both actives on their mechanism of transport when formulated in cosmetic compositions. The experiments were performed using a proprietary iontophoretic device containing a roller to apply the formulation. Three current profiles were tested: (i) galvanic direct current (DC), (ii) square unipolar pulse current (SPC), and (iii) galvanic direct current (DC) + pulse current (PC). The skin samples were collected at different sampling points, extracted an…