Search results for "Mace"
showing 10 items of 4713 documents
Aerosolization Performance of Jet Nebulizers and Biopharmaceutical Aspects
2019
In this work, 13 jet nebulizers, some of which in different configurations, were investigated in order to identify the biopharmaceutical constraints related to the quality attributes of the medicinal products, which affect their safety, efficiency, compliance, and effectiveness. The aerosolization parameters, including the aerosol output, aerosol output rate, mass median aerodynamic diameter, and fine particle fraction, were determined according to the European Standard EN 13544-1, using sodium fluoride as a reference formulation. A comparison between the aerosol output nebulization time and the fine particle fraction displayed a correlation between the aerosol quality and the nebulization …
La responsabilità da prodotto difettoso
2014
Optimization of Spray-Drying Process of
2019
Jerusalem artichoke is an important natural matrix for inulin production. In this experiment, response surface methodology (RSM) was employed to optimize the spray-drying parameters in order to determine the maximal inulin yield. For this study, three independent variables (heating temperature (Tª, 110–120 °C), creep speed (V, 18–22 rpm) and pressure (P, 0.02–0.04 MPa)) were used in the experimental design. Using the Box–Behnken design, the optimal parameters obtained were: drying temperature 114.6 °C, creep speed 20.02 rpm, and pressure: 0.03 MPa. The inulin yield, water content and particle size of inulin obtained by spray-drying and freeze-drying were compared. In this regard, the spray-…
Phytochemical investigation of the needles of Abies nebrodensis (Lojac.) Mattei
2019
Abies nebrodensis (Lojac.) Mattei (Pinaceae) is a species living in a very small population only in a confined area of Sicily. In this study, the dichloromethane extract of the leaves was analyzed. Apart from three already known metabolites namely dehydroabietic acid; maltol; and rheosmin, previously detected in other species of Abies, a lanostane derivative was isolated. Its chemical structure was elucidated by means of extensive spectroscopic methods.
Photoluminescent Detection of Human T-Lymphoblastic Cells by ZnO Nanorods.
2020
The precise detection of cancer cells currently remains a global challenge. One-dimensional (1D) semiconductor nanostructures (e.g., ZnO nanorods) have attracted attention due to their potential use in cancer biosensors. In the current study, it was demonstrated that the possibility of a photoluminescent detection of human leukemic T-cells by using a zinc oxide nanorods (ZnO NRs) platform. Monoclonal antibodies (MABs) anti-CD5 against a cluster of differentiation (CD) proteins on the pathologic cell surface have been used as a bioselective layer on the ZnO surface. The optimal concentration of the protein anti-CD5 to form an effective bioselective layer on the ZnO NRs surface was selected. …
NMR-based quantification of rosmarinic and carnosic acids, GC-MS profile and bioactivity relevant to neurodegenerative disorders of Rosmarinus offici…
2013
Abstract A comparative study of phytochemicals content and biological properties of eight Rosmarinus officinalis (rosemary) populations (RO1–RO8) collected in different areas of Tunisia was carried out. Two of the main rosemary constituents, rosmarinic and carnosic acids, were quantified by an NMR technique. Carnosic acid content was higher than that of rosmarinic acid. The non-polar constituents were examined by GC and GC–MS. Total phenols and flavonoids content were also determined in order to discuss the possible correlation between these phytochemicals and bioactivity. Antioxidant activity was investigated through different in vitro assays. Sample RO3 from a sub-humid area showed the hi…
Development of high-performance thin layer chromatography method for identification of phenolic compounds and quantification of rosmarinic acid conte…
2020
ABSTRACT Aim: Representatives of Nepetoideae Burnett subfamily are promising species of the Lamiaceae Martinov family because of accumulating such valuable groups of secondary metabolites as terpenoids and polyphenols. A high-performance thin layer chromatography (HPTLC) fingerprint method for the qualitative determination of phenolic compounds and for the quantification of rosmarinic acid (RA) content in methanol extracts of five species of this subfamily was developed for the first time. Materials and Methods: Dried aerial parts of Dracocephalum moldavica L., Ocimum americanum L., Lophanthus anisatus (Nutt.) Benth., Monarda fistulosa L., and Satureja hortensis L. collected in flowering pe…
Tenapanor for the treatment of irritable bowel syndrome with constipation.
2020
Introduction: Irritable bowel syndrome with constipation is associated with higher rates of functional impairment, as compared to other subtypes of the syndrome. Conventional laxative-based pharmacologic therapy of IBS-C, which is mostly symptom-based, is often unsatisfactory. Tenapanor represents a first-in-class orally available inhibitor of NHE3, which is minimally absorbed in the GI tract, what constitutes a significant therapeutic benefit, as it may act on the drug target. Areas covered: Aim of this article is to sum up the evidences about pharmacodynamics and pharmacokinetics of tenapanor, focusing on animal models and in vitro studies, but also discuss clinical trials on tenapanor's …
Condiciones optimas de manipulación para la cuantificación de fibronectina en saliva
2004
Introducción: La fibronectina (Fn) es una glucoproteína presente en múltiples fluidos y tejidos orgánicos, tanto en condiciones fisiológicas como patológicas. También en la saliva puede detectarse aunque en muy pequeñas cantidades y frecuentemente en cadenas fragmentadas, induce agregación bacteriana y sus niveles se reducen cuando aumentan los niveles de bacterias cariogénicas o periodontopatógenas. La capacidad infectiva de la saliva de los pacientes infectados por el virus de la inmunodificiencia humana (VIH) se ha relacionado con los niveles de esta proteína. En algunas enfermedades crónicas de la mucosa oral como es el liquen plano, la concentración de Fn salivar se encuentra reducida.…
Augu izcelsmes un sintētisko caurejas līdzekļu aprite aptiekā no 2015. līdz 2017. gadam un pacientu aptaujas izvērtējums
2017
Aizcietējums ir zarnu trakta traucējums, kas raksturojas ar vēdera izeju retāku par trim reizēm nedēļā. Aizcietējuma laikā novērojami nepatīkami simptomi, kas būtiski traucē dzīves kvalitātei. Maģistra darba mērķis ir analizēt caurejas līdzekļu aprites datus par diviem gadiem un, izmantojot anketēšanas metodi, analizēt iegūtos datus par caurejas līdzekļu lietošanu. Aprites dati parāda, ka visvairāk pārdotie sintētiskie caurejas līdzekļi ir makrogols, Fortrans (osmotiskie caurejas līdzekļi) un bisakodils (stimulējošais caurejas līdzeklis). No augu izcelsmes līdzekļiem visvairāk pārdotie bija sennu saturošie līdzekļi, arī pēc aptaujas datiem sennas preparāti atzīmēti biežāk, no sintētiskajiem…