Search results for "Mace"
showing 10 items of 4713 documents
Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum
2012
WOS: 000306752700042
Polymeric nanoparticles for siRNA delivery: Production and applications
2017
Gene therapy through the use of siRNA and a polymeric carrier are becoming an efficient therapeutic option to conventional pharmaceutical formulations for the treatment of deadly diseases, such as cancer, pulmonary, ocular and neurodegenerative diseases. However, several considerations regarding the stability, formulation, and efficacy have to be faced up until these systems could be considered to be a marketable pharmaceutical products for to extend siRNA application to clinical practice. This review is focused on the key challenges of siRNA therapeutics, with special attention on the faced obstacles and on the formulation-related difficulties, providing a list of requirements needed for o…
Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.
2021
Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…
Inulin Derivatives Obtained Via Enhanced Microwave Synthesis for Nucleic Acid Based Drug Delivery
2015
A new class of therapeutic agents with a high potential for the treatment of different socially relevant human diseases is represented by Nucleic Acid Based Drugs (NABD), including small interfering RNAs (siRNA), decoy oligodeoxynucleotides (decoy ODN) and antisense oligonucleotides (ASOs). Although NABD can be engineered to be specifically directed against virtually any target, their susceptibility to nuclease degradation and the difficulty of delivery into target tissues severely limit their use in clinical practice and require the development of an appropriate nanostructured delivery system. For delivery of NABD, Inulin (Inu), a natural, water soluble and biocompatible polysaccharide, wa…
Valorization of Side Stream Products from Sea Cage Fattened Bluefin Tuna (Thunnus thynnus): Production and In Vitro Bioactivity Evaluation of Enriche…
2022
The valorization of side streams from fishery and aquaculture value-chains is a valuable solution to address one of the challenges of the circular economy: turning wastes into profit. Side streams produced after filleting of sea cage fattened bluefin tuna (Thunnus thynnus) were analyzed for proximate composition and fatty acid profile to evaluate the possibility of producing tuna oil (TO) as a valuable source of ω-3 polyunsaturated fatty acids (PUFA) and testing its bioactivity in vitro. Ethyl esters of total fatty acids (TFA), obtained from TO, were pre-enriched by urea complexation (PUFA-Ue) and then enriched by short path distillation (SPD) up to almost 85% of the PUFA fraction (PU…
UPTAKE OF SILICA COVERED QUANTUM DOTS ON LIVING CELLS: LONG TERM VITALITY AND MORPHOLOGY STUDY ON HYALURONIC ACID BIOMATERIALS
2015
In this work we prepared colloidal CdSe-CdS core-shell nanocrystal emitting @625 nm and, by a micro-emulsion procedure of water in oil inverse micelle, we encapsulated a single dot inside each silica sphere. In this way the nanoparticles became biocompatible, are simply to prepare and could be used also in a water based environment. Moreover, the silica shield is transparent to the wavelengths of interest.
DELIVERY DI SOSTANZE ATTIVE DEL SISTEMA NERVOSO CENTRALE MEDIANTE PROFARMACI O SISTEMI PARTICELLARI
2012
Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals
2021
This study proposes a review on hyaluronic acid (HA) known as hyaluronan or hyaluronate and its derivates and their application in cosmetic formulations. HA is a glycosaminoglycan constituted from two disaccharides (N-acetylglucosamine and D-glucuronic acid), isolated initially from the vitreous humour of the eye, and subsequently discovered in different tissues or fluids (especially in the articular cartilage and the synovial fluid). It is ubiquitous in vertebrates, including humans, and it is involved in diverse biological processes, such as cell differentiation, embryological development, inflammation, wound healing, etc. HA has many qualities that recommend it over other substances used…
Microneedle-Based Delivery: An Overview of Current Applications and Trends
2020
Microneedle arrays (MNA) are considered as one of the most promising resources to achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally invasive, painless system which can bypass the stratum corneum, overcoming the potential drawbacks of subcutaneous injections and other transdermal delivery systems such as chemical enhancers, nano and microparticles, or physical treatments. As a trendy field in pharmaceutical and biomedical research, its applications are constantly evolving, even though they are based on very well-established techniques. The number of molecules administered by MNA are also increasing, with insulin and vaccines administration being the …
Assessment of the moisturizing potential of a two-phase topical care product containing vegetable oils, glycerin, panthenol, and sodium hyaluronate -…
2022
The presence of moisturizing substances and lipid substances determines the integrity of the epidermis cells and their barrier functions because it protects the interior of the body against environmental changes: temperature, humidity, ultraviolet radiation, pollution, and the effects of detergents. In this study, we performed a non-invasive, preliminary evaluation of the effects of a biphasic facial skin care product containing plant oils, hyaluronic acid, glycerin, and panthenol on skin hydration levels and transepidermal water loss compared to a control group using only shea butter. The topical care product formed as a two-phase emulsion was tested. The research was carried out with the …