Search results for "Macro"

A protective role for interleukin 18 in interferon γ-mediated innate immunity to Cryptosporidium parvum that is independent of natural killer cells.

2012

Innate immunity against some intracellular parasitic protozoa involves interleukin 18 (IL-18)-mediated interferon γ (IFN-γ) production by natural killer (NK) cells, but the role of IL-18 in innate resistance to Cryptosporidium infection is unknown. Adult Rag2(-/-)γc(-/-) mice that lack NK cells, T cells, and B cells demonstrated resistance to Cryptosporidium parvum infection that was IFN-γ dependent. Treatment with anti-IL-18-neutralizing antibodies resulted in loss of resistance correlating with reduced intestinal IFN-γ expression. Intestinal mature IL-18 expression increased in vivo during infection and also in the intestinal epithelial cell line CMT-93 following combined IFN-γ treatment/…

Differential expression of mRNA encoding interleukin-12 p35 and p40 subunitsin situ

1994

Interleukin-12 (IL-12) is a heterodimeric cytokine that plays an important role in the regulation of the immune response. For biological activity the expression of both subunits of IL-12, p35 and p40, is required. Moreover, in the mouse the p40 chain of IL-12 specifically inhibits the effects of the IL-12 heterodimer. In the present study we have analyzed by in situ hybridization the expression of the p35 and p40 mRNA in the spleens of BALB/c and mutant (SCID, nude, beige) mice, unstimulated and after in vivo stimulation with lipopolysaccharide (LPS) and with staphylococcal enterotoxin B (SEB). In unstimulated spleens of BALB/c mice p35 and p40 mRNA were only detectable in a few strongly st…

The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment

2020

The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified because of its key role in the regulation of glycogen synthesis. However, it is now well-established that GSK-3 performs critical functions in many cellular processes, such as apoptosis, tumor growth, cell invasion, and metastasis. Aberrant GSK-3 activity has been associated with many human diseases, including cancer, highlighting its potential therapeutic relevance as a target for anticancer therapy. Recently, newly emerging data have demonstrated the pivotal role of GSK-3 in the anticancer immune response. In the last few years, many GSK-3 inhibitors have been developed, and some are currently being te…

Economic Globalization: From Microeconomic Foundation to National Determinants

2015

Abstract For many years, globalization was at the main source of economic growth for the world economy. During and after the 2009 crisis many questions about the positive effects of globalization have arisen. In this paper we argue there are two dimensions of economic globalization, micro and macro, and the perspectives of globalization is more related to the microeconomic determinants. Looking to the definitions and measures of globalization we conclude that for most of the countries the macro dimensions are important and many of them irreversible and not questionable in these days – barriers of trade, political integration, etc., but the microeconomic behavior of individuals and companies…

Mobilities and the network of personal technologies: Refining the understanding of mobility structure

2017

Our ambition here is to refine the various typologies that compose the mobility structure. We aim to complement the work done by Urry and investigate the role played in the structure of mobility by what we call the “network of personal technologies”. Our new model consists of four different levels: macro-mobilities, micro-mobilities, media mobility and disembodied mobilities. By “macro-mobilities,” we refer to the actions which imply consistent physical displacement, such as travels, tours and commuting. By “micro-mobilities,” we mean small-scale displacements, including bodily movements and emotions. With moving media, we refer both to the new mobility provided by the smartphone to the tra…

Incremental elastoplastic analysis for active macro-zones

2012

In this paper a strategy to perform incremental elastoplastic analysis using the symmetric Galerkin boundary element method for multidomain type problems is shown. The discretization of the body is performed through substructures, distinguishing the bem-elements characterizing the so-called active macro-zones, where the plastic consistency condition may be violated, and the macro-elements having elastic behaviour only. Incremental analysis uses the well-known concept of self-equilibrium stress field here shown in a discrete form through the introduction of the influence matrix (self-stress matrix). The nonlinear analysis does not use updating of the elastic response inside each plastic loop…

Un approccio innovativo per la modellazione degli edifici in muratura intelaiata. Applicazione ad un caso di studio

2013

Le strutture in muratura intelaiata rappresentano una parte rilevante delle strutture esistenti e sono ancora largamente adottate come sistema strutturale per la costruzione di edifici residenziali, soprattutto in aree del mondo a forte sismicità non fortemente industrializzate e nelle quali la muratura rappresenta ancora un materiale tradizionale e a basso costo. In questo lavoro viene presentato un approccio per macro-elementi per la valutazione della risposta sismica di strutture in muratura confinata. La complessa interazione tra il telaio e la muratura è simulata mediante un approccio originale in cui il telaio è modellato con aste a plasticità concentrata mentre il contributo della mu…

2016

Background Contractile myofibroblasts (MFs) accumulate in the joint capsules of patients suffering from posttraumatic joint stiffness. MF activation is controlled by a complex local network of growth factors and cytokines, ending in the increased production of extracellular matrix components followed by soft tissue contracture. Despite the tremendous growth of knowledge in this field, inconsistencies remain in practice and prevention.

Silicate modulates the cross-talk between osteoblasts (SaOS-2) and osteoclasts (RAW 264.7 cells): inhibition of osteoclast growth and differentiation

2012

It has been shown that inorganic monomeric and polymeric silica/silicate, in the presence of the biomineralization cocktail, increases the expression of osteoprotegerin (OPG) in osteogenic SaOS-2 sarcoma cells in vitro. In contrast, silicate does not affect the steady-state gene expression level of the osteoclastogenic ligand receptor activator of NF-κB ligand (RANKL). In turn it can be expected that the concentration ratio of the mediators OPG/RANKL increases in the presence of silicate. In addition, silicate enhances the growth potential of SaOS-2 cells in vitro, while it causes no effect on RAW 264.7 cells within a concentration range of 10-100 µM. Applying a co-cultivation assay system,…

Lymphatic vessels of the dura mater: a new discovery?

2015

Aspelund et al. discover the presence of a lymphatic vessel network in the dura mater of the mouse brain and show that these dural lymphatic vessels are important for the clearance of macromolecules from the brain.