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STRUMENTI E METODI PER INTEGRARE GLI ASPETTI AMBIENTALI NELLA MANUTENZIONE DEL PATRIMONIO ARCHITETTONICO
2022
La corretta e costante applicazione della manutenzione può assumere un ruolo chiave per garantire la qualità del patrimonio costruito e il soddisfacimento delle più recenti classi di requisiti ambientali. A tal fine, è necessario che le strategie che guidano la programmazione delle attività di manutenzione siano modellate sulle caratteristiche del manufatto in esame. In Italia una larga parte degli edifici risulta edificata prima del 1946 e, molti di questi seppur non strettamente tutelati dalla legge, possono presentare rilevanti caratteri morfologici o costruttivi che vanno opportunamente conservati. La manutenzione, condotta in un’ottica sistemica e multiscalare, comprendendo interventi …
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides
2012
Irreversible epidermal growth factor receptor (EGFR) inhibitors contain a reactive warhead which covalently interacts with a conserved cysteine residue in the kinase domain. The acrylamide fragment, a commonly employed warhead, effectively alkylates Cys797 of EGFR, but its reactivity can cause rapid metabolic deactivation or nonspecific reactions with off-targets. We describe here a new series of irreversible inhibitors containing a 3-aminopropanamide linked in position 6 to 4-anilinoquinazoline or 4-anilinoquinoline-3- carbonitrile driving portions. Some of these compounds proved to be as efficient as their acrylamide analogues in inhibiting EGFR-TK (TK = tyrosine kinase) autophosphorylati…
Dissection of the relative contribution of the Schizosaccharomyces pombe Ctr4 and Ctr5 proteins to the copper transport and cell surface delivery fun…
2011
The Ctr1 family of proteins mediates high-affinity copper (Cu) acquisition in eukaryotic organisms. In the fission yeastSchizosaccharomyces pombe, Cu uptake is carried out by a heteromeric complex formed by the Ctr4 and Ctr5 proteins. Unlike human andSaccharomyces cerevisiaeCtr1 proteins, Ctr4 and Ctr5 are unable to function independently in Cu acquisition. Instead, both proteins physically interact with each other to form a Ctr4–Ctr5 heteromeric complex, and are interdependent for secretion to the plasma membrane and Cu transport activity. In this study, we usedS. cerevisiaemutants that are defective in high-affinity Cu uptake to dissect the relative contribution of Ctr4 and Ctr5 to the Cu…
Identification of a specific type of PD from acoustic emission frequency spectra
2001
The paper presents an attempt to apply spectral analysis tools in processing acoustic emission (AE) pulses generated by partial discharge (FD). The experimental part of the paper describes spark gaps generating four types of PD and specifies parameters of measured acoustic signals and recalls the system used for measurement and analysis of the frequency spectra. Also, a spectral analysis procedure is presented, and frequency-domain descriptors characterizing AE pulses are defined. The results of the analysis are given both as time plots and amplitude and energy density spectra, related to values of the associated descriptors. The spectral analysis results cover AE pulses generated in system…
Comparative analysis of acoustic emission signals generated by electrical discharges measured by the hydrophone and the wideband contact transducer
2005
The paper presents a comparative analysis of the acoustic emission (AE) pulses and signals generated by PDs. For this purpose the measurements of the acoustic emission signals generated by PDs were taken in the multipoint-plane system using a hydrophone placed directly in the area of discharge generation, and the AE pulses using a piezoelectric contact transducer which was on a side wall of a power transformer tub. Next, time runs and amplitude density spectra were drawn. Also the descriptors describing signals in the frequency domain were determined and the time-frequency analysis was carried out, which determined spectrograms for the energy density spectrum.
Investigating the level of significance of the coherence function in cardiovascular variability analysis
2002
Although the presence of significant coupling between cardiovascular variability series is usually verified according to the threshold value of 0.5 in the coherence function (CF), spectral estimator parameters should also be considered. In this study, the surrogate data technique was introduced to define the level of significance of the CF. The proposed method determined a frequency-dependent threshold over which the hypothesis of zero coherence was rejected. The weighted covariance method and the autoregressive method were used to estimate the CF on simulated series with different degrees of linear coupling and on real cardiovascular data. The threshold was dependent on the type and parame…
The Navier–Stokes equations in exterior Lipschitz domains: L -theory
2020
Abstract We show that the Stokes operator defined on L σ p ( Ω ) for an exterior Lipschitz domain Ω ⊂ R n ( n ≥ 3 ) admits maximal regularity provided that p satisfies | 1 / p − 1 / 2 | 1 / ( 2 n ) + e for some e > 0 . In particular, we prove that the negative of the Stokes operator generates a bounded analytic semigroup on L σ p ( Ω ) for such p. In addition, L p - L q -mapping properties of the Stokes semigroup and its gradient with optimal decay estimates are obtained. This enables us to prove the existence of mild solutions to the Navier–Stokes equations in the critical space L ∞ ( 0 , T ; L σ 3 ( Ω ) ) (locally in time and globally in time for small initial data).
Découverte d'un ex-voto particulier sur le site cultuel d'Essarois (Côte-d'Or) : un cas de polydactylie chez les Gallo-Romains ?
2011
During geo-archaeological research on the slope where the source associated with the Essarois (Côte-d'Or) cult site is located, in the locality of La Cave, an anatomic votive offering of a human foot was discovered in the alluvial sedimentary deposits. Carved from local oolitic limestone, it is rather crude in appearance but it is possible to make out that it has the unusual number of six toes. Although it may have been a blunder or the result of negligence by the sculptor, the phenomenon may equally have been a deliberate representation of a case of polydactyly, a malformation that was known in Antiquity.
Angiotensin Receptor Neprilysin Inhibition Compared With Enalapril on the Risk of Clinical Progression in Surviving Patients With Heart Failure
2015
Background— Clinical trials in heart failure have focused on the improvement in symptoms or decreases in the risk of death and other cardiovascular events. Little is known about the effect of drugs on the risk of clinical deterioration in surviving patients. Methods and Results— We compared the angiotensin-neprilysin inhibitor LCZ696 (400 mg daily) with the angiotensin-converting enzyme inhibitor enalapril (20 mg daily) in 8399 patients with heart failure and reduced ejection fraction in a double-blind trial. The analyses focused on prespecified measures of nonfatal clinical deterioration. In comparison with the enalapril group, fewer LCZ696-treated patients required intensification of med…
Mass Accretion Processes in Young Stellar Objects: Role of Intense Flaring Activity
2014
According to the magnetospheric accretion scenario, young low-mass stars are surrounded by circumstellar disks which they interact with through accretion of mass. The accretion builds up the star to its final mass and is also believed to power the mass outflows, which may in turn have a significant role in removing the excess angular momentum from the star-disk system. Although the process of mass accretion is a critical aspect of star formation, some of its mechanisms are still to be fully understood. On the other hand, strong flaring activity is a common feature of young stellar objects (YSOs). In the Sun, such events give rise to perturbations of the interplanetary medium. Similar but mo…