Search results for "Main"

Social–ecological connections across land, water, and sea demand a reprioritization of environmental management

2022

International audience; Despite many sectors of society striving for sustainability in environmental management, humans often fail to identify and act on the connections and processes responsible for social-ecological tipping points. Part of the problem is the fracturing of environmental management and social-ecological research into ecosystem domains (land, freshwater, and sea), each with different scales and resolution of data acquisition and distinct management approaches. We present a perspective on the social-ecological connections across ecosystem domains that emphasize the need for management reprioritization to effectively connect these domains. We identify critical nexus points rel…

Spatial Forecast Verification Methods Intercomparison Project: Application of the SAL Technique

2009

Abstract In this study, a recently introduced feature-based quality measure called SAL, which provides information about the structure, amplitude, and location of a quantitative precipitation forecast (QPF) in a prespecified domain, is applied to different sets of synthetic and realistic QPFs in the United States. The focus is on a detailed discussion of selected cases and on the comparison of the verification results obtained with SAL and some classical gridpoint-based error measures. For simple geometric precipitation objects it is shown that SAL adequately captures errors in the size and location of the objects, however, not in their orientation. The artificially modified (so-called fake…

Sea-surface temperature co-variability in the Southern Atlantic and Indian Oceans and its connections with the atmospheric circulation in the Souther…

2003

The relationship between sea-surface temperature (SST) inter-annual variability at the subtropical and midlatitudes of the southern Atlantic and Indian Oceans and its links with the atmospheric circulation in the Southern Hemisphere are investigated over the 1950–1999 period. Exploratory analysis using singular value decomposition and further investigations based on simple indices show that a large part of regional SST variability is common between the southwestern parts of both basins at subtropical and midlatitudes during the austral summer. Interestingly, these areas are also significantly associated with the far southwestern Pacific (Tasman Sea area). The patterns and time series of co-…

ZERODUR based optical systems for quantum gas experiments in space

2019

Abstract Numerous quantum technologies make use of a microgravity environment e.g. in space. Operating in this extreme environment makes high demands on the experiment and especially the laser system regarding miniaturization and power consumption as well as mechanical and thermal stability. In our systems, optical modules consisting of ZERODUR® based optical benches with free-space optics are combined with fiber components. Suitability of the technology has been demonstrated in the successful sounding rocket missions FOKUS, KALEXUS and MAIUS-1. Here, we report on our toolkit for stable optical benches including mounts, fixed and adjustable mirrors as well as polarization maintaining fiber …

Étude de l’attractivité et de la fidélisation auprès d’établissements d’accueil de personnes âgées de deux bassins territoriaux

2015

International audience; Actuellement le marché du travail des jeunes subit encore l’instabilité de la conjoncture économique et sociale née à partir du milieu des années soixante dix, à la fin de la période des « trente glorieuses ». Ce marché est également paradoxal car, malgré un taux de chômage élevé de la population des jeunes actifs, certains secteurs d’activité, ne parviennent ni à embaucher, ni à fidéliser leur personnel. Cette communication présente une analyse des mesures prises par des organisations pour attirer et fidéliser une main d’œuvre jeune et pour la faire progresser dans un contexte de précarisation des parcours professionnels qui impacte les pratiques de fidélisation dép…

From Topology to Quasi-Topology. The Complexity of the Notional Domain

2016

This article examines a fundamental metalinguistic construction of the theory of enunciative operations: the notional domain. In particular, we try to explain some elementary topological concepts on which this construction is based and we try to show the key role they play in the description of some basic linguistic operations.

Front propagation in the one-dimensional autocatalyticA+B→2Areaction with decay

1999

We consider front propagation in the autocatalytic scheme $A+\stackrel{\ensuremath{\rightarrow}}{B}2A,$ where we also allow the A particles to decay, $\stackrel{\ensuremath{\rightarrow}}{A}0,$ with a constant decay rate $\ensuremath{\beta}.$ In a one dimensional, discrete, situation the A domain moves as a pulse, and its dynamics differs from what is found in higher dimensions. Thus the velocity of the pulse tends to a finite value when $\ensuremath{\beta}$ approaches from below the critical value ${\ensuremath{\beta}}_{c},$ at which pulses die out. On the other hand, when approaching ${\ensuremath{\beta}}_{c}$ from above, the mean lifetime of the pulse grows as $T\ensuremath{\propto}(\ensu…

2020

BAG3, a multifunctional HSP70 co-chaperone and anti-apoptotic protein that interacts with the ATPase domain of HSP70 through its C-terminal BAG domain plays a key physiological role in cellular proteostasis. The HSP70/BAG3 complex determines the levels of a large number of selective client proteins by regulating their turnover via the two major protein degradation pathways, i.e. proteasomal degradation and macroautophagy. On the one hand, BAG3 competes with BAG1 for binding to HSP70, thereby preventing the proteasomal degradation of its client proteins. By functionally interacting with HSP70 and LC3, BAG3 also delivers polyubiquitinated proteins to the autophagy pathway. BAG3 exerts a numbe…

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3.

2009

The Hsc/Hsp70 co-chaperones of the BAG (Bcl-2-associated athanogene) protein family are modulators of protein quality control. We examined the specific roles of BAG1 and BAG3 in protein degradation during the aging process. We show that BAG1 and BAG3 regulate proteasomal and macroautophagic pathways, respectively, for the degradation of polyubiquitinated proteins. Moreover, using models of cellular aging, we find that a switch from BAG1 to BAG3 determines that aged cells use more intensively the macroautophagic system for turnover of polyubiquitinated proteins. This increased macroautophagic flux is regulated by BAG3 in concert with the ubiquitin-binding protein p62/SQSTM1. The BAG3/BAG1 ra…

Preparation and Characterization of P2 BCh Ring Systems (Ch=S, Se) and Their Reactivity with N-Heterocyclic Carbenes

2018

Four-membered rings with a P2BCh core (Ch = S, Se) have been synthesized via reaction of phosphinidene chalcogenide (Ar*P=Ch) and phosphaborene (Mes*P=BNR2). The mechanistic pathways towards these rings are explained by detailed computational work that confirmed the preference for the formation of P–P, not P–B, bonded systems, which seems counterintuitive given that both phosphorus atoms contain bulky ligands. The reactivity of the newly synthesized heterocycles, as well as that of the known (RPCh)n rings (n = 2, 3), was probed by the addition of Nheterocyclic carbenes, which revealed that all investigated compounds can act as sources of low-coordinate phosphorus species. peerReviewed