Search results for "Major"
showing 10 items of 1120 documents
"Table 100" of "Studies of QCD at e+ e- centre-of-mass energies between 91-GeV and 209-GeV."
2004
Thrust Major distribution at c.m. energy 200.00 GeV.
Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth.
2013
International audience; Dacarbazine (DTIC) is a cytotoxic drug widely used for melanoma treatment. However, the putative contribution of anticancer immune responses in the efficacy of DTIC has not been evaluated. By testing how DTIC affects host immune responses to cancer in a mouse model of melanoma, we unexpectedly found that both natural killer (NK) and CD8(+) T cells were indispensable for DTIC therapeutic effect. Although DTIC did not directly affect immune cells, it triggered the upregulation of NKG2D ligands on tumor cells, leading to NK cell activation and IFNγ secretion in mice and humans. NK cell-derived IFNγ subsequently favored upregulation of major histocompatibility complex cl…
Gynecomastia
2020
Gynecomastia is a swelling of the male breast as a result of the growth of two components: The adipose and the glandular tissue, sometimes unilateral, but more often occurring in bilateral form. Several classification systems were proposed, based on the hypertrophy of the tissue and the position of the nipple-areola complex. The clinical examination and blood analysis play an important role in excluding endocrine tumors or hormone balance modification and in choosing the treatment. The management of gynecomastia considers the drug therapy in case of hormones disorder. But surgical procedures, such as the combined adenectomy/liposuction, represent the gold standard of treatment. Skin redunda…
Sleep disorders in the elderly with and without chronic airflow obstruction: the SARA study
2003
Objectives: Our objectives were to test the hypothesis that, in the geriatric population, chronic airway obstruction is associated with a higher prevalence of sleep disturbances; to identify the main correlates of sleep disturbances, and to verify whether asthma and COPD patients have different patterns of sleep disturbances. Methods: The EPESE questionnaire was administered to 734 patients aged 65 years and over with asthma or chronic obstructive pulmonary disease (cases) and 1237 individuals of comparable age who were free of respiratory disease but not of other chronic conditions (controls). Four sleep disturbances were quantified: difficulty in falling asleep, nocturnal awakening, morni…
EPA guidance on physical activity as a treatment for severe mental illness: a meta-review of the evidence and Position Statement from the European Ps…
2018
AbstractPhysical activity (PA) may be therapeutic for people with severe mental illness (SMI) who generally have low PA and experience numerous life style-related medical complications. We conducted a meta-review of PA interventions and their impact on health outcomes for people with SMI, including schizophrenia-spectrum disorders, major depressive disorder (MDD) and bipolar disorder. We searched major electronic databases until January 2018 for systematic reviews with/without meta-analysis that investigated PA for any SMI. We rated the quality of studies with the AMSTAR tool, grading the quality of evidence, and identifying gaps, future research needs and clinical practice recommendations.…
Towards an Understanding of the Causes of Difficulties in Debugging
2018
Debugging remains one of the areas that have seen little progress since the early days of programming. We argue that the academic approach of observational studies is incapable of capturing the essence of debugging in complex software. Instead, reflections by programmers may provide a better description of the debugging nature and challenges. In this article, we describe a study where we capture the reflections of programmers on thorny bugs that exemplify the major sources of difficulties in debugging. More importantly, we provide suggestions on what could have been done to avoid such thorny bugs from occurring with the same level of difficulties. As a major conclusion, we argue that the be…
Deconstructing incubation behaviour in response to ambient temperature over different timescales
2021
Avian embryos need a stable thermal environment to develop optimally, while incubat-ing females need to allocate time to self-maintenance off the nest. In species with female-only incubation, eggs are exposed to ambient temperatures that usually cool them down during female absences. The lower the ambient temperature the sooner females should return to re-warm the eggs. When incubation constraints ease at increasing ambient temperatures, females respond by increasing either incubation effort or self-maintenance time. These responses are population-dependent even within the same species; but it is uncertain whether they are caused by local environmental conditions or they are an artefact fro…
Transferencia valor-experiencia a través del patrocinio deportivo : antecedentes y consecuencias
2021
El estudio propone un modelo de patrocinio deportivo que toma como eje la transferencia entre evento y marca en términos de valor y experiencia, abundando en sus antecedentes y efectos. Encuestando en 2012 a 364 asistentes al GP de Fórmula 1 de València se concluye que no se transfiere el valor del evento a la marca, pero sí la experiencia. Asimismo, se observa que ambos términos (experiencia y valor) están significativamente relacionados. Adicionalmente, se confirma que motivación, identificación e implicación son antecedentes del eje del modelo, junto con todos los efectos propuestos. This study proposes a general model for sports sponsorship which takes as its central concept the transfe…
Sterile neutrino portal to Dark Matter I: the U(1) B−L case
2017
In this paper we explore the possibility that the sterile neutrino and Dark Matter sectors in the Universe have a common origin. We study the consequences of this assumption in the simple case of coupling the dark sector to the Standard Model via a global $U(1)_{B-L}$, broken down spontaneously by a dark scalar. This dark scalar provides masses to the dark fermions and communicates with the Higgs via a Higgs portal coupling. We find an interesting interplay between Dark Matter annihilation to dark scalars - the CP-even that mixes with the Higgs and the CP-odd which becomes a Goldstone boson, the Majoron - and heavy neutrinos, as well as collider probes via the coupling to the Higgs. Moreove…
Distinguishing Majorana Zero Modes from Impurity States through Time-Resolved Transport
2019
We study time-resolved charge transport in a superconducting nanowire using time-dependent Landauer-B{\"u}ttiker theory. We find that the steady-state Majorana zero-bias conductance peak emerges transiently accompanied by characteristic oscillations after a bias-voltage quench. These oscillations are absent for a trivial impurity state that otherwise shows a very similar steady-state signal as the Majorana zero mode. In addition, we find that Andreev bound states or quasi-Majorana states in the topologically trivial bulk phase can give rise to a zero-bias conductance peak, also retaining the transient properties of the Majorana zero mode. Our results imply that (1) time-resolved transport m…