Search results for "Mali"
showing 10 items of 3900 documents
A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration
2021
The most recent revision of the World Health Organization (WHO) Classification of Tumours of Endocrine Organs introduced a new variant of follicular thyroid carcinoma (FTC). It is characterized by a “glomeruloid” architectural pattern of growth. We present a case of follicular tumor with glomeruloid features, with Alcian Blue positive mucinous stromal degeneration in foci of questionable capsular microinvasion. At our knowledge, this the second case of glomeruloid follicular tumor in the literature and the first case in which Alcian Blue staining was used to investigate capsular invasion. Moreover, RAS mutation further supports that this is a variant of follicular tumor with uncertain malig…
Particularismes i populismes als països de llengua catalana
2020
[cat] L'article analitza breument l'ampla varietat de conceptes de populisme en la política actual. Aquesta anàlisi intenta mostrar com el populisme ha donat suport als particularismes lingüístics a València i a Mallorca. Aquests particularismes (anomenats blaverisme a València, i gonellisme a Mallorca) no reconeixen la unitat de la comunitat lingüística catalana, i per tant amenacen la recuperació social (normalització) de la llengua catalana.
Fabra i l'Autoritat lingüística al país valencià: l'institut d'estudis valencians (1937-1939)
2020
Davant la dificultat d'acceptar al País Valencià l'autoritat lingüística de l'IEC i la codificació de la llengua catalana, Fabra reconegué en almenys tres declaracions (1918, 1930 i 1937), que corresponia als escriptors valencians la tasca de depurar i de redreçar la llengua i admeté que la constitució d'un centre d'estudis filològics al País Valencià hi podria ajudar. No es pronuncià sobre les Normes de Castelló, però s'interessà per la seua aplicació i, com a president de l'IEC, mantingué una bona relació amb l'Institut d'Estudis Valencians (1937-1939), creat per Francesc Bosch i Morata a imitació de l'IEC. La creació de l'Institut d'Estudis Valencians (= IEV) fou una aspiració constant d…
¿Diccionario? normatiu ¿valencià?
2016
¿Diccionario? normatiu ¿valencià?
Memòria i ficció: metaficció historiogràfica en la narrativa de Jesús Moncada
2017
The critical reception of Jesus Moncada's work has been determined by critical debate that opposed rural literature and urban literature in the eighties of the twentieth century. From this perspective, the narrative of Moncada has been identified with the desire to preserve the memory of Mequinensa, disappeared under the water. The paper proposes a reading of author's work from the historiographic metafiction in which the exercise of memory is not to be understood as the desire to preserve against forgetting a lost world, but as a question about mechanisms of understanding of the real one, about conditionings and limits on access to knowledge of history and about relationship between fictio…
Aproximació a la morfosintaxi dels quantificadors en el català del segle XVII
2018
Our paper intends to analyse the sentences which have the quantifiers u (un), 'one', and cada u (cada un), 'everyone', in the Catalan language of the 17th century. This research studies specifically the cases of masculine singular form in external position in detail. The study shows that historically there are morphological alternations between the apocopated form (u) and non-apocopated form (un). But this variation suggests differences in Catalan dialects. Methodologically, the investigation is based on a large corpus of texts from the main Catalan dialects. We describe, classify and quantify the linguistic uses of the quantifiers studied, which reveals that several factors interact in var…
Altered morphological and electrophysiological properties of Cajal-Retzius cells in cerebral cortex of embryonic Presenilin-1 knockout mice
2004
Mutations of Presenilin-1 are the major cause of familial Alzheimer's disease. Presenilin-1 knockout (PS1-/-) mice develop severe cortical dysplasia related to human type 2 lissencephaly. This overmigration syndrome has been attributed to the premature loss of Cajal-Retzius cells (CRcs), pioneer neurons required for the termination of radial neuronal migration. To elucidate the potential cellular mechanisms responsible for this premature neuronal loss, we investigated the morphological and electrophysiological properties of visually identified CRcs of wild-type (WT) and PS1-/- mouse brains at embryonic day 16.5. The density of CRcs was substantially reduced in the cerebral cortex of PS1-/-.…
The glucose-dependent transport of L-malate in Zygosaccharomyces bailii.
1984
Zygosaccharomyces bailii possesses a constitutive malic enzyme, but only small amounts of malate are decomposed when the cells ferment fructose. Cells growing anaerobically on glucose (glucose cells) decompose malate, whereas fructose cells do not. Only glucose cells show an increase in the intracellular concentration of malate when suspended in a malate-containing solution. The transport system for malate is induced by glucose, but it is repressed by fructose. The synthesis of this transport system is inhibited by cycloheximide. Of the two enantiomers L-malate is transported preferentially. The transport of malate by induced cells is not only inhibited by addition of fructose but also inac…
Synthesis and antiproliferative activity of substituted 3[2-(1H-indol-3-yl)-1,3-thiazol-4-yl]-1H-pyrrolo[3,2-b]pyridines, marine alkaloid nortopsenti…
2014
A large number of indolyl-4-azaindolyl thiazoles, nortopsentin analogues, were conveniently synthesized. The antiproliferative activity of the new derivatives was examined against four human tumor cell lines with different histologic origin. Seven derivatives consistently reduced the growth of the experimental models independently of TP53 gene status and exhibited the highest activity against the malignant peritoneal mesothelioma (STO) cell line. The most active compound of this series acts as a CDK1 inhibitor, and was found to cause cell cycle arrest at G 2 /M phase, to induce apoptosis by preventing the phosphorylation of survivin in Thr 34 and to increase the cytotoxic activity of paclit…
Proliferative activity and tumorigenic conversion: impact on cellular metabolism in 3-D culture
2001
Oxygen consumption, glucose, lactate, and ATP concentrations, as well as glucose and lactate turnover rates, have been studied in a three-dimensional carcinogenesis model of differently transformed rat embryo fibroblasts (spontaneously immortalized Rat1 and myc-transfected M1, and the ras-transfected, tumorigenic descendants Rat1-T1 and MR1) to determine metabolic alterations that accompany tumorigenic conversion. Various bioluminescence techniques, thymidine labeling, measurement of[Formula: see text] distributions with microelectrodes, and determination of cellular oxygen uptake rates (Q˙[Formula: see text]) have been applied. In the ras-transfected, tumorigenic spheroid types, the size d…