Search results for "Mania"
showing 10 items of 710 documents
La movilidad geográfica de búlgaros y rumanos durante la Gran Recesión en España
2021
El objetivo de este artículo es analizar las pautas de movilidad de los inmigrantes procedentes de Bulgaria y Rumania durante la grave crisis económico-laboral que afecta a España. La información utilizada procede de entrevistas en profundidad a migrantes búlgaros y rumanos, que se completa con datos del Instituto Nacional de Estadística y del Ministerio de Empleo y Seguridad Social. Los resultados muestran el fuerte incremento de la movilidad interprovincial de trabajadores, sobre todo en los primeros años y con un destacado protagonismo de los varones, y el progresivo aumento de la migración internacional, que adopta diversas formas: retorno, migración circular entre el lugar de origen y …
Implementing Intellectual Property Policies in a Romanian State University
2018
The paper presents a series of contributions on the possibility of implementing intellectual property policies in a Romanian State University. Starting with the worldwide, well-known examples of universities with a tradition in this field of intellectual property protection, the paper presents practical solutions for the implementation of some intellectual property policies taking into account the mentality which currently exists in Romania on this subject. The study is based on the important experience gained by authors in a European research project involving 15 partners from 9 countries, where the results were remarkable. The University must represent a pole of excellence in research, bu…
Computational Identification of Chemical Compounds with Potential Activity against Leishmania amazonensis using Nonlinear Machine Learning Techniques.
2019
Leishmaniasis is a poverty-related disease endemic in 98 countries worldwide, with morbidity and mortality increasing daily. All currently used first-line and second-line drugs for the treatment of leishmaniasis exhibit several drawbacks including toxicity, high costs and route of administration. Consequently, the development of new treatments for leishmaniasis is a priority in the field of neglected tropical diseases. The aim of this work is to develop computational models those allow the identification of new chemical compounds with potential anti-leishmanial activity. A data set of 116 organic chemicals, assayed against promastigotes of Leishmania amazonensis, is used to develop the the…
In vitro leishmanicidal activity of pyrazole-containing polyamine macrocycles which inhibit the Fe-SOD enzyme of Leishmania infantum and Leishmania b…
2014
The in vitro leishmanicidal activity and cytotoxicity of pyrazole-containing macrocyclic polyamines 1-4 was assayed on Leishmania infantum and Leishmania braziliensis species. Compounds 1-4 were more active and less toxic than glucantime and both infection rates and ultrastructural alterations confirmed that 1 and 2 were highly leishmanicidal and induced extensive parasite cell damage. Modifications in the excretion products of parasites treated with 1-3 were also consistent with substantial cytoplasm alterations. Compound 2 was highlighted as a potent inhibitor of Fe-SOD in both species, whereas its effect on human CuZn-SOD was poor. Molecular modelling suggested that 2 could deactivate Fe…
In vitro and in silico studies of polycondensed diazine systems as anti-parasitic agents
2012
Abstract Parasitic diseases caused by protozoarian agents are still relevant today more than ever. Recently, we synthesized several polycondensed diazine derivatives by means 1,3-dipolar cycloaddition reactions. A broad selection of these compounds were submitted to in vitro biological screening against Plasmodium falciparum , Leishmania infantum , Trypanosoma brucei , and Trypanosoma cruzi , resulting active at micromolar level. Induced Fit Docking/MM-GBSA studies were performed giving interesting indications about the probable mechanism of action of the most active compounds
2015
Characterization of host-pathogen interactions is a fundamental approach in microbiological and immunological oriented disciplines. It is commonly accepted that host cells start to change their phenotype after engulfing pathogens. Techniques such as real time PCR or ELISA were used to characterize the genes encoding proteins that are associated either with pathogen elimination or immune escape mechanisms. Most of such studies were performed in vitro using primary host cells or cell lines. Consequently, the data generated with such approaches reflect the global RNA expression or protein amount recovered from all cells in culture. This is justified when all host cells harbor an equal amount o…
Multivariate regression analysis applied to the calibration of equipment used in pig meat classification in Romania.
2016
This paper highlights the statistical methodology used in a dissection experiment carried out in Romania to calibrate and standardize two classification devices, OptiGrade PRO (OGP) and Fat-o-Meat'er (FOM). One hundred forty-five carcasses were measured using the two probes and dissected according to the European reference method. To derive prediction formulas for each device, multiple linear regression analysis was performed on the relationship between the reference lean meat percentage and the back fat and muscle thicknesses, using the ordinary least squares technique. The root mean squared error of prediction calculated using the leave-one-out cross validation met European Commission (EC…
Sentieri interrotti. Musicisti europei nel crepuscolo dell'Occidente
2012
Il volume descrive il contesto in cui vedono la luce le due mostre dedicate all’Arte Degenerata (Monaco 1937) e alla Musica Degenerata (Düsseldorf 1938), soffermandosi in modo particolare sui percorsi biografici e artistici di quattro compositori la cui biografia venne sconvolta dalla politica culturale nazista: Franz Schreker, Alexander Zemlinsky, Erich Wolfgang Korngold e Viktor Ullmann. Si tratta di autori di origine ebraica, legati in vario modo alla vita musicale di città come Berlino, Vienna e Praga, assai diversi per formazione e linguaggio, ma tutti travolti da una serie di eventi (l'avvento al potere di Hitler, la guerra, la Shoah) che trasformarono i loro percorsi biografici in al…
Esuberanza e mistero
2011
Il testo è stato realizzato in occasione di un'esecuzione della Sinfonia n. 8 in sol maggiore op. 88 di Antonìn Dvoràk e di due brani vocali di Johannes Brahms: "Schicksalslied" per coro e orchestra op. 54 e "Naenie" per coro e orchestra op. 82. In particolare, per quanto riguarda le opere di Brahms, viene analizzato il contesto biografico in cui vedono la luce e il rapporto fra la struttura musicale e i testi poetici di Hoelderlin e di Schiller.
Destino della musica europea nell'epoca dei regimi totalitari
2001
Il saggio descrive, con particolare riferimento all'ambito della musica colta, i principali aspetti della politia culturale nell'Italia fascista, nella Germania nazista e in Unione Sovietica.