Search results for "Map"

A systems biology perspective on cholangiocellular carcinoma development: focus on MAPK-signaling and the extracellular environment.

2008

Background/Aims Multiple genes have been implicated in cholangiocellular carcinoma (CCC) development. However, the overall neoplastic risk is likely associated with a much lower number of critical physiological pathways. Methods To investigate this hypothesis, we extracted all published genetic associations for the development of CCC from PubMed (genetic association studies, but also studies associating genes and CCC in general, i.e. functional studies in cell lines, genetic studies in humans, knockout mice etc.) and integrated CCC microarray data. Results We demonstrated the MAPK pathway was consistently enriched in CCC. Comparing our data to genetic associations in HCC often successfully …

Source localization of event-related potentials to pitch change mapped onto age-appropriate MRIs at 6 months-of-age

2010

Auditory event-related potentials (ERPs) have been used to understand how the brain processes auditory input, and to track developmental change in sensory systems. Localizing ERP generators can provide invaluable insights into how and where auditory information is processed. However, age-appropriate infant brain templates have not been available to aid such developmental mapping. In this study, auditory change detection responses of brain ERPs were examined in 6-month-old infants using discrete and distributed source localization methods mapped onto age-appropriate magnetic resonance images. Infants received a passive oddball paradigm using fast-rate non-linguistic auditory stimuli (tone do…

Spatial representations of the future in Homeric Greek

The aim of this paper is to investigate the space-time mapping of the future in Homeric Greek. It is widely accepted that the spatial adverbs πρόσσω ‘in front’ and ὀπίσσω ‘behind’ in the Homeric poems are used to portray temporal events located in a sequence of aligned entities that follow one after the other on the same path (Dunkel 1983: 66). In such a temporal sequence, or Time-RP model, those adverbs are associated respectively to past and future events in a dichotomous spatial representation of time, without involving a deictic ego-experiencer. After analyzing data from the Homeric poems in a cognitive linguistic perspective, it is found that some temporal uses of the preposition πρό ‘…

Land Surface Temperature

2019

Abstract An introduction to the chapter on Land Surface Temperature (LST). The basic thermal infrared theory is presented with example algorithms for the retrieval of LST and emissivity data are described in the later section. Various methods to validate satellite Land Surface Temperature (LST) products exist, but the most accurate and conclusive method is the direct comparison against in situ LST obtained from spatially representative radiance measurements over homogeneous sites. Some validation results and insights found in the literature are provided and the determination of in situ emissivity and LST with thermal infrared field radiometers is explained. The chapter concludes with an exa…

ICA of full complex-valued fMRI data using phase information of spatial maps.

2015

Background ICA of complex-valued fMRI data is challenging because of the ambiguous and noisy nature of the phase. A typical solution is to remove noisy regions from fMRI data prior to ICA. However, it may be more optimal to carry out ICA of full complex-valued fMRI data, since any filtering or voxel-based processing may disrupt information that can be useful to ICA. New method We enable ICA of the full complex-valued fMRI data by utilizing phase information of estimated spatial maps (SMs). The SM phases are first adjusted to properly represent spatial phase changes of all voxels based on estimated time courses (TCs), and then these are used to segment the voxels into BOLD-related and unwant…

The colour of light for urban spaces

2013

Light in urban spaces was first introduced to prevent crimes against both people and properties and, while there is no study that confirms crimes' reduction in lit spaces, it is undeniable that people feel safer in lit urban spaces. Over the years it became evident that light can also improve the liveability of cities and enhance their characteristics, therefore in the last years a growing attention was paid to urban lighting design taking into account the environmental impact and energy saving requirements too. The will to use the lighting design project to improve the liveability of historical centres it’s clear: the city during the night is no more conceived like a sum of lit architectur…

A directional spectral mixture analysis method: application to multiangular airborne measurements

2006

This study aims at developing an operational approach-namely, directional spectral mixture analysis (DISMA)-for retrieving vegetation parameters like fractional vegetation cover (FVC) and leaf area index (LAI) from multispectral and multiangular data. The approach attempts to highlight the consistency of one-dimensional models and linear mixture approaches. DISMA combines spectral signatures of soil and vegetation components with an analytical approximation of the radiative transfer equation, giving rise to a fast invertible bidirectional reflectance distribution function (BRDF) model of discontinuous canopies. Both the forward model and its inversion using a simple technique based on looku…

Delineation of Malignant Skin Tumors by Hyperspectral Imaging

2018

This chapter outlines a new non-invasive method for delineation of skin lesions such as lentigo maligna and lentigo maligna melanoma. The method is based on the analysis of hyperspectral (HS) images taken in vivo before surgical excision of the lesions. For this, characteristic features of the spectral signatures of diseased pixels and healthy pixels are extracted, which combine the intensities in a few selected wavebands with the coefficients of the wavelet frame transforms of the spectral curves. To reduce dimensionality and to reveal the internal structure of the datasets, the diffusion maps (DM) technique is applied. The averaged Nearest Neighbor and the Classification and Regression Tr…

The Fluorescence Explorer (FLEX) Mission: From Spectral Measurements to High-Level Science Products

2021

The Fluorescence Explorer (FLEX) mission was selected in 2015, by the European Space Agency (ESA), as an Earth Explorer mission, with a launch planned for 2024. The key scientific objective of the mission is the quantitative global mapping of actual photosynthetic activity of terrestrial ecosystems, as a function of variable vegetation health status and environmental stress conditions. The measurements will have a spatial resolution of 300 m, adequate to resolve land surface processes associated to vegetation dynamics at a global scale. To be able to accomplish such objective, the FLEX mission carries the FLORIS spectrometer, specially optimized to map vegetation fluorescence with a spectra…

Detection and localisation of disulphide bonds in a synthetic peptide reproducing the sequence 1-30 of Par j 1.0101 by electrospray ionisation mass s…

2001

The structural characterisation of a synthetic peptide reproducing the sequence 1–30 of Par j 1.0101, a major allergenic protein present in the pollen of Parietaria judaica, by combined use of chemical and enzymatic cleavage, reversed-phase high-performance liquid chromatography (RP-HPLC) and electrospray ionisation mass spectrometry (ESI-MS), is described. Direct ESI-MS of the synthetic peptide after reaction with methyl iodide showed that the product is a mixture of two peptides: one form in which two out of the four cysteine residues present in the sequence are oxidised and a minor amount of another form in which all the cysteines are fully reduced. It was ascertained, using the combined…