Search results for "Marck"

Curcumin modulates chronic myelogenous leukemia exosomes composition and affects angiogenic phenotype, via exosomal miR-21

2016

Abstract: Tumor derived exosomes are vesicles which contain proteins and microRNAs that mediate cell-cell communication and are involved in angiogenesis and tumor progression. Curcumin derived from the plant Curcuma longa, shows anticancer effects. Exosomes released by CML cells treated with Curcumin contain a high amount of miR-21 that is shuttled into the endothelial cells in a biologically active form. The treatment of HUVECs with CML Curcu-exosomes reduced RhoB expression and negatively modulated endothelial cells motility. We showed that the addition of CML control exosomes to HUVECs caused an increase in IL8 and VCAM1 levels, but Curcu-exosomes reversed these effects thus attenuating …

Solid-Phase Synthesis and Biological Evaluation of a Teleocidin Library—Discovery of a Selective PKC Down Regulator

2000

Protein kinaseC (PKC) is linked to the signal-induced modulation of a wide variety of cellular processes, such as growth, differentiation, secretion, apoptosis, and tumor development. The design and synthesis of small molecules that regulate these different cellular signaling systems is at the forefront of modern drug design. Herein we report a) an efficient method for the synthesis of indolactamV (6), a PKC activator, and its N13-des(methyl) analogues (19) using a regioselective organometallic transformation, a convenient aminomalonate derivative (10) to introduce the appropriate functionality and an enantiospecific enzymic hydrolysis as key steps; b) the use of this method in the first so…

Expression of protein kinase C gene family members is temporally and spatially regulated during neural development in vitro.

1998

We used primary cultures of rat hippocampal neurons and PCC7-Mz1 cells to correlate the expression of the protein kinase C (PKC) gene family with specific events during neural differentiation. Multipotent PCC7-Mz1 embryonic carcinoma stem cells develop into a tissue-like pattern of neuronal, fibroblast-like and astroglial cells by all-trans retinoic acid (RA) treatment. Western blot analyses demonstrate that PKCalpha, betaI, gamma, theta, mu, lambda, and zeta were constitutively expressed but the expression of PKCbetaII, delta, epsilon, and eta was up-regulated three days after addition of RA when cells mature morphologically. While the protein levels of the PKC isoforms betaII, delta and e…

1793 - I BENI NATURALI DIVENTANO BENI CULTURALI

2009

Il 1793 fu l’anno in cui l’istruzione fu riformata in Francia. Erano passati quattro anni dalla Rivoluzione e si imponevano nuovi criteri per l’insegnamento delle Scienze Naturali, che dovevano diventare la base di una nuova cultura, più attenta a tutti i viventi e meno antropocentrica. Come emblemi del passato, le Chiese venivano chiuse, o dedicate ad altre funzioni: così stava per succedere alla Chiesa di Saint Sulpice a Parigi che, dopo una grande festa popolare di inaugurazione, doveva diventare Tempio della Filosofia. Il periodo era assai turbolento e pericoloso, tanto che fu in seguito chiamato Terrore. Il Governo stesso temeva distruzioni e atti di vandalismo, soprattutto verso due s…

Iris bismarckiana in Israel and Jordan—New findings and taxonomic remarks

2001

Iris bismarckiana (Iris section Oncocyclus) was found for the first time in the west Gilead in Jordan. This discovery was utilized to shed some light on the taxonomic relationships among the light-colored irises in the Levant. Morphometric quantitative analysis of the Jordanian population compared to I. bismarckiana allies in Israel (I. bismarckiana in the Galilee and I. hermona in the Golan) suggests that the Jordanian population is I. bismarckiana, despite the large distance from the main distribution area. Cluster analysis, based on the morphology, revealed that some of the populations of I. bismarckiana have closer affinities to I. hermona than to each other. Populations of I. hermona a…

Data from: Phylogenomics of Lophotrochozoa with consideration of systematic error

2021

Phylogenomic studies have improved understanding of deep metazoan phylogeny and show promise for resolving incongruences among analyses based on limited numbers of loci. One region of the animal tree that has been especially difficult to resolve, even with phylogenomic approaches, is relationships within Lophotrochozoa (the animal clade that includes molluscs, annelids, and flatworms among others). Lack of resolution in phylogenomic analyses could be due to insufficient phylogenetic signal, limitations in taxon and/or gene sampling, or systematic error. Here, we investigated why lophotrochozoan phylogeny has been such a difficult question to answer by identifying and reducing sources of sys…

Data from: Phylogenomics of Lophotrochozoa with consideration of systematic error

2016

Phylogenomic studies have improved understanding of deep metazoan phylogeny and show promise for resolving incongruences among analyses based on limited numbers of loci. One region of the animal tree that has been especially difficult to resolve, even with phylogenomic approaches, is relationships within Lophotrochozoa (the animal clade that includes molluscs, annelids, and flatworms among others). Lack of resolution in phylogenomic analyses could be due to insufficient phylogenetic signal, limitations in taxon and/or gene sampling, or systematic error. Here, we investigated why lophotrochozoan phylogeny has been such a difficult question to answer by identifying and reducing sources of sys…

Le conchiglie di Lamarck come beni culturali

2012

Con questo contributo si è voluto ricordare che nella turbolenta Francia nel 1793 per la prima volta i beni naturali vengono ufficialmente riconosciuti anche come beni culturali facenti parte del patrimonio di un popolo, che li deve custodire e tutelare. Il tutto era scaturito dalla necessità di salvare dalla distruzione due acquasantiere costituite da 2 valve di tridacna, una conchiglia esotica, presenti nella Chiesa di S. Sulpice a Parigi. A questo importante evento partecipò attivamente anche Jean Baptiste Lamarck, Professore di Zoologia degli Insetti e dei Vermi presso il Museo Nazionale di Storia Naturale di Parigi. Proprio dallo studio delle conchiglie attuali, comparate con quelle fo…

"Hyi, olenko minä suloinen!" : tyttökirjat tarjoavat samastumiskohteita lukijoille, esimerkkeinä Eevan luokka, Priska ja Rakas Laura

2012

p42 MAPK phosphorylates 80 kDa MARCKS at Ser-113.

1996

Abstract It is demonstrated here that p42 MAPKinase (p42 MAPK) phosphorylates the M yristoylated A lanine- R ich C - K inase S ubstrate (MARCKS) at Ser-113. In permeabilised Swiss 3T3 cells activation of protein kinase C (PKC) leads to p42 MAPK activation, but only the protein kinase C sites in MARCKS become phosphorylated and not Ser-113. The mitogen platelet-derived growth factor (PDGF) elicits the same response. These results demonstrate that while Ser-113 is a substrate for p42 MAPK in vitro and can be phosphorylated in vivo as shown by Taniguchi et al. [(1994) J. Biol. Chem. 269, 18299–18302], its phosphorylation is not subject to acute regulation by p42 MAPK in Swiss 3T3 cells.