Search results for "Marginal"
showing 10 items of 350 documents
A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies.
2011
A20/TNFAIP3 is an ubiquitin-editing enzyme, important for the regulation of the NF-κB pathway. Mutations in the TNFAIP3 gene have been linked to different human autoimmune disorders. In human B-cell lymphomas, the inactivation of A20 results in constitutive NF-κB activation. Recent studies demonstrate that in mice the germline inactivation of A20 leads to early lethality, due to inflammation in multiple organs of the body. In this report, we describe a new mouse strain allowing for the tissue-specific deletion of A20. We show that B-cell-specific deletion of A20 results in a dramatic reduction in marginal zone B cells. Furthermore, A20-deficient B cells display a hyperactive phenotype repre…
Molte Palermo. Temi
2019
Nel tema delle incompiute idee di città possibili si riconoscerà il paradigma connotativo dello stesso divenire di Palermo, lungo un percorso millenario di processi di trasformazione nessuno dei quali portato a compimento, in virtù di quel valore distintivo di exemplum che non necessita di ulteriori e conclusive dimostrazioni. Il corso della storia, del resto, ha imposto a Palermo il ciclico riproporsi di destini interrotti. Tale si rilevò l’invenzione della città capitale, quella della “quadratura geometrica e della croce di strade” sovrimpressa a quella archetipica e fondativa della Pan-ormos scambiatrice. E l’incompiutezza sarà il tratto distintivo della città dei rettifili stradali otto…
Inflation and optimal monetary policy in a model with firm heterogeneity and Bertrand competition
2018
Abstract We study the joint implications of heterogeneity of total factor productivity and strategic price interactions between firms on the dynamics of inflation and the design of optimal monetary policy. In this setting, more productive firms respond less to shocks affecting their marginal costs than less productive firms. As a consequence, economies with a larger proportion of highly productive firms face a flatter Phillips curve. Moreover, when these two features concur, the Ramsey problem gives rise to an optimal non-zero long run inflation that amplifies the differences in relative prices between more efficient and less efficient firms, thus increasing the market share of the former. …
Market Polarization and the Phillips Curve
2021
The Phillips curve has flattened out over the last decades. We develop a model that rationalizes this phenomenon as a result of the observed increase in polarization in many industries, a process along which a few top firms gain an increasing share of their industry market. In the model, firms compete a la Bertrand and there is exit and endogenous market entry, as well as optimal up and downgrading of technology. Firms with larger market shares find optimal to dampen the response of their price changes, thus cushioning the shocks to their marginal costs through endogenous countercyclical markups. Thus, regardless of its causes (technology, competition, barriers to entry, etc.), the recent i…
Intersectional scholarship & positive youth development: Post-modern paradigm shift in understanding adjustment of marginalized youth
2016
Research on intersectionality of marginalized youth is generally situated in the assumption that non-normative identity leads to pathology and victimization. Further, most research to date has studied marginalized youth using a traditional nuclear family paradigm. In this paper we discuss how intersectionality addresses the combination of strengths and challenges of living with stigmatizing identities and family processes, towards developing successful youth adjustment. We apply the three-step intersectionality approach to study findings among a group of racial/ethnic minority and sexual minority identified youth and discuss the particular role of familism and extended kinship support belie…
Indagine preliminare sul germoplasma di Capparis spinosa subsp. rupestris (Sm.) Nyman dell'isola di Linosa
2009
Il cappero è un suffrutice presente nella flora spontanea del Mediterraneo. Nelle isole minori della Sicilia, in particolare a Pantelleria, Salina e di recente anche a Linosa, il cappero si è affermato in coltura specializzata, acquistando una certa importanza sia in termini economici, ma anche sociali ed ambientali. Questa produzione, infatti, molto apprezzata dai turisti, ha creato un certo volume di commercio locale, consentendo agli agricoltori di realizzare buoni utili. Le caratteristiche di rusticità, tipiche della specie, lo sviluppo e l’architettura dell’apparato radicale le conferiscono, inoltre, un ruolo rilevante nella prevenzione dei processi di erosione del suolo. L’attività in…
Mary Wollstonecraft och autonomins uppkomst:
2018
Uppsatsen granskar marginaliseringen av kvinnor i filosofins historia genom att fästa uppmärksamhet vid hur filosofihistorieskrivningen bidragit till denna marginalisering. Utgångspunkten är J. B Schneewinds inflytelserika bok The Invention of Autonomy (1998) och det faktum att Schneewind, trots ett explicit intresse för en egalitär moralfilosofi och ett brett fokus på moralfilosofis utveckling, inte inkluderat en enda kvinnlig tänkare. Uppsatsen består av fem avsnitt. Först presenterar jag några generella synpunkter på filosofihistorieskrivningens marginaliseringsmekanismer. Det andra avsnittet presenterar Schneewinds huvudargument och i det tredje granskar jag hans val att inte inkludera …
Satisfacción laboral de los asalariados en España
2012
El objetivo de este trabajo es identificar los factores determinantes del nivel de satisfacción laboral de los asalariados en España, haciendo especial hincapié en las diferencias de género y de nacionalidad. Para ello, se estima un modelo de respuesta múltiple ordenada, utilizando los datos de la Encuesta de Calidad de Vida en el Trabajo, para el período que abarca desde 2006 a 2010. Los resultados obtenidos muestran que, después de controlar por las características personales y laborales de los asalariados, se obtiene un diferencial positivo en la satisfacción laboral en favor de las mujeres, mientras que no se evidencia la existencia de un efecto diferencial entre los asalariados nativos…
Asunnottomana yhteiskunnassa : helsinkiläisten ja jyväskyläläisten asunnottomien näkemyksiä asioinnista viranomaisten kanssa
2003
Belìce Valley: from earthquake to local development perspectives
2019
This paper aims to retrace, through a critic study of the scientific debate, the Belice Valley’s territorial context after the 1968 violent earthquake and to identify the actual development perspectives of the area. By using official dataset and consolidated bibliography we identify the peculiar weakness of the socio-economical structure of Belice Valley, a marginal territory of Sicily (Italy), when the earthquake stroke, but also the start of a local identity building process in the aftermath of the seism. We also recognize, in the LAG—Local Action Group—strategy, a possibility to strenghten, nowadays, the local development of the area through the utilization of its milieu and its own pote…