Search results for "Marginal"

Creating and sustaining local entrepreneurs: a Schumpeterian view of economic growth

2010

In his Theory of economic development and Business cycles Joseph Schumpeter explained the long and short-run importance of an economy’s credit system to the vitality of entrepreneurship. Famously, the entrepreneur is the key figure in the process of innovating the structure of an economy, according to Schumpeter, which is the secret to the long term growth record of capitalist economies. In this project we use Schumpeter’s ideas about the relationship between credit, innovation, and growth in order to evaluate the current state of this relationship in the Mediterranean region, using Sicily as a case study. Based on the case of Sicily we then suggest ways in which local, as opposed to global…

Marginal abatement cost of carbon dioxide emissions in the provision of urban drinking water

2021

Abstract Reducing greenhouse gas emissions is a major challenge faced by cities seeking to improve their environmental sustainability. Doing so requires a good understanding of the costs associated with lowering emissions and factors that may influence this cost. This study estimated the marginal abatement cost of reducing both direct and indirect CO2 emissions in the provision of drinking water by several water companies in England and Wales. The results indicated that during the years 2013–2018, the average cost to the English and Welsh water industry to prevent 1 kg of CO2 emissions was 0.264₤ which was equivalent to 61% of the price of the delivered drinking water The results of the Mor…

A Critical Review of Statistical Methods for Twin Studies Relating Exposure to Early Life Health Conditions

2021

International audience; When investigating disease etiology, twin data provide a unique opportunity to control for confounding and disentangling the role of the human genome and exposome. However, using appropriate statistical methods is fundamental for exploiting such potential. We aimed to critically review the statistical approaches used in twin studies relating exposure to early life health conditions. We searched PubMed, Scopus, Web of Science, and Embase (2011–2021). We identified 32 studies and nine classes of methods. Five were conditional approaches (within-pair analyses): additive-common-erratic (ACE) models (11 studies), generalized linear mixed models (GLMMs, five studies), gene…

Personality modulates brain responses to emotion in music: Comparing whole-brain and regions-of-variance approaches

2019

AbstractWhether and how personality traits explain the individual variance in neural responses to emotion in music remains unclear. The sparse studies on this topic report inconsistent findings. The present study extends previous work using regions of variance (ROVs) as regions of interest, compared with whole-brain analysis. Fifty-five subjects listened to happy, sad, and fearful music during functional Magnetic Resonance Imaging. Personality was measured with the Big Five Questionnaire. Results confirmed previous observations of Neuroticism being positively related to activation during sad music, in the left inferior parietal lobe. In an exploratory analysis, Openness was positively relat…

Simulation-based marginal likelihood for cluster strong lensing cosmology

2015

Comparisons between observed and predicted strong lensing properties of galaxy clusters have been routinely used to claim either tension or consistency with $\Lambda$CDM cosmology. However, standard approaches to such cosmological tests are unable to quantify the preference for one cosmology over another. We advocate approximating the relevant Bayes factor using a marginal likelihood that is based on the following summary statistic: the posterior probability distribution function for the parameters of the scaling relation between Einstein radii and cluster mass, $\alpha$ and $\beta$. We demonstrate, for the first time, a method of estimating the marginal likelihood using the X-ray selected …

The effect of composite resin preheating on marginal adaptation of class II restorations

2020

Background One of the problems with a high filler content composite resins is gap formation at restorative material-tooth interface. The present study investigated the effect of preheating composite resins on the formation of marginal gap in Cl II restorations. Material and Methods In this in vitro study Sixty Cl II cavities were prepared on the mesial and distal surfaces of 30 extracted premolar teeth. The gingival floor of cavities was placed 1 m below the CEJ. The samples were randomly allocated to 4 groups for restoration placement: group 1, Filtek P60 composite resin at room temperature; group 2, Filtek P60 composite resin at 68°C; group 3, X-tra fil composite resin at room temperature…

La derechización del mundo / 3

2007

Transporter-mediated replacement of extracellular glutamate for GABA in the developing murine neocortex

2013

During early development, cortical neurons migrate from their places of origin to their final destinations where they differentiate and establish synaptic connections. During corticogenesis, radially migrating cells move from deeper zone to the marginal zone, but they do not invade the latter. This "stop" function of the marginal zone is mediated by a number of factors, including glutamate and γ-aminobutyric acid (GABA), two main neurotransmitters in the central nervous system. In the marginal zone, GABA has been shown to be released via GABA transporters (GAT)-2/3, whereas glutamate transporters (EAATs) operate in the uptake mode. In this study, GABAergic postsynaptic currents (GPSCs) were…

Bilateral Monopoly: A Contribution by Francesco Ferrara

2009

In this paper, we propose an interpretation of the application of "cost of reproduction" of Francesco Ferrara to the exchange between two agents to highlight its relevance for the theory of bilateral monopoly. In the Teoria delle Mercedi (1863), Ferrara gives a numerical example to explain price determination in the exchange between one buyer and one seller. Here, this example is translated into a mathematical model that reproduces the fundamental issues of the neoclassical debate on the indeterminacy of price in the Cournot model (1938), and anticipates the solutions proposed by Edgeworth (1881) at the end of this debate.

Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes

2021

Aim: Recessive genetic variation is thought to play a role in non-Hodgkin lymphoma (NHL) etiology. Runs of homozygosity (ROH), defined based on long, continuous segments of homozygous SNPs, can be used to estimate both measured and unmeasured recessive genetic variation. We sought to examine genome-wide homozygosity and NHL risk.Methods: We used data from eight genome-wide association studies of four common NHL subtypes: 3061 chronic lymphocytic leukemia (CLL), 3814 diffuse large B-cell lymphoma (DLBCL), 2784 follicular lymphoma (FL), and 808 marginal zone lymphoma (MZL) cases, as well as 9374 controls. We examined the effect of homozygous variation on risk by: (1) estimating the fraction o…