Search results for "Marker"
showing 10 items of 3799 documents
Differences in metabolic profiles of planktonic and biofilm cells in Staphylococcus aureus - (1)H Nuclear Magnetic Resonance search for candidate bio…
2013
Staphylococcus aureus is responsible for many types of infections related to biofilm presence. As the early diagnostics remains the best option for prevention of biofilm infections, the aim of the work presented was to search for differences in metabolite patterns of S. aureus ATCC6538 biofilm vs. free-swimming S. aureus planktonic forms. For this purpose, Nuclear Magnetic Resonance (NMR) spectroscopy was applied. Data obtained were supported by means of Scanning Electron Microscopy, quantitative cultures and X-ray computed microtomography. Metabolic trends accompanying S. aureus biofilm formation were found using Principal Component Analysis (PCA). Levels of isoleucine, alanine and 2,3-but…
dglars: An R Package to Estimate Sparse Generalized Linear Models
2014
dglars is a publicly available R package that implements the method proposed in Augugliaro, Mineo, and Wit (2013), developed to study the sparse structure of a generalized linear model. This method, called dgLARS, is based on a differential geometrical extension of the least angle regression method proposed in Efron, Hastie, Johnstone, and Tibshirani (2004). The core of the dglars package consists of two algorithms implemented in Fortran 90 to efficiently compute the solution curve: a predictor-corrector algorithm, proposed in Augugliaro et al. (2013), and a cyclic coordinate descent algorithm, proposed in Augugliaro, Mineo, and Wit (2012). The latter algorithm, as shown here, is significan…
Lead-time and overdiagnosis estimation in neuroblastoma screening.
2003
In Germany, neuroblastoma is the most frequent extracranial solid childhood tumour. Its properties made it seem an ideal candidate for screening. A German trial assessed the effect of screening at one year of age from 1995-2001 in a nationwide project. We present here the methods developed for the estimation of lead-time and overdiagnosis in this project. Follow up on 1.5 million screened children and 2.1 million control children is currently available until June 2002. Ascertainment of control cohort cases and false negative cases is complete up to this date. A method for determining an empirical lead-time distribution and overdiagnosis estimate from comparing the age specific incidences in…
Towards next-generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomics.
2020
5 páginas, 2 figuras. AVAILABILITY AND IMPLEMENTATION: The database of non-tuberculous mycobacteria assemblies can be accessed at: 10.5281/zenodo.3374377. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online: http://dx.doi.org/10.1093/bioinformatics/btz729
Recent advances in surface plasmon resonance biosensors for microRNAs detection
2020
miRNAs are a large family of non-coding RNAs which play important roles in translational and post-transcriptional regulation of gene expression and biological processes. Abnormal expression of miRNAs is related to the initiation and progression of different diseases which make them be promising candidates for early medical diagnostics. Thus, accurate detection of miRNAs has great significance for disorder diagnosis. Nevertheless, their intrinsic characteristics such as short sequence, low concentration and sequence homology challenge routine techniques. The detection assays need to be extremely sensitive and selective in small value of intricate RNA samples. Biosensor-based strategies have …
Il ruolo dell’infiammazione nella prognosi del recupero funzionale dei pazienti in assistenza domiciliare integrata
2010
This study has correlated the functional recovery achieved by patients treated in integrated home care following a stroke or a fracture with biochemical parameters, lipid profile and nutritional status. The study involved 51 patients (average age 79.5 years) who were receiving home rehabilitation treatment. A statistically significant association between functional improvement and lower levels of fibrinogen, PCR, LDL-cholesterol and BUN emerged. The study supports the need for further investigation on the predictive role of inflammatory markers.
Discourse Markers in Speech: Distinctive Features and Corpus Annotation
2017
It is generally acknowledged that discourse markers are used differently in speech and writing, yet many general descriptions and most annotation frameworks are written-based, thus partially unfit to be applied in spoken corpora. This paper identifies the major distinctive features of discourse markers in spoken language, which can be associated with problems related to their scope and structure, their meaning and their tendency to co-occur. The description is based on authentic examples and is followed by methodological recommendations on how to deal with these phenomena in more exhaustive, speech-friendly annotation models.
El valor estructurador de ¿no? un estudio a través de la conversación, la entrevista y el monólogo
2018
En este artículo se pretenden detallar los valores como estructurador de la información del marcador del discurso ¿no?, un elemento cuyo carácter interpersonal resulta el rasgo de mayor prominencia. Para ello, se lleva a cabo un estudio que se centra en el comportamiento de esta forma en tres géneros discursivos orales: la conversación, la entrevista y el monólogo. A través de un análisis con corpus, se presenta, por una parte, una macrofunción que pretende explicar el valor estructurador de ¿no? desde su naturaleza interactiva y, por otra, un inventario de funciones que recogen la manera concreta en la que este marcador estructura la información.
Genetic Variability and Taxonomical Considerations about Six Species of European Cardueline Finches (Aves, Passeriformes)
1997
Abstract Electrophoretic patterns of seven enzyme systems and two nonenzymatic proteins, albumin and haemoglobin, representing 13 loci, have been investigated in six species of cardueline finches with Palearctic distribution. A new locus, SOD-3, has been characterized in this subfamily. The two nonenzymatic proteins turned out to be the best genetic markers. From the analysis of the genetic distances it emerges that the mean values between species are higher than those reported for other groups of birds. However, the same results were obtained for other species of the same subfamily native to North America. In both cases this result is probably due to a classification that disagrees with th…
Violent and/or delinquent women: a vision from the biopsychosocial perspective
2015
Violence and/or delinquency in women have been masked to some extent by society. Thus, the main goal of this work is to deeply analyse the published works on these matters, in order to understand this phenomenon from a neurobiological perspective. Firstly, the theory of the cycle of violence as a facilitating mechanism of violence in women will be analysed, with a special emphasis on neuroanatomical correlates. Subsequently, the relation between drug consumption and violence in women will be explained. Finally, the main biological correlates known as facilitating mechanisms of violence in women will be exhaustively described. The main risk factors for the facilitation of violence and/or del…