Search results for "Marr"
showing 10 items of 776 documents
Editorial: Genetics and gene therapy of lysosomial storage disorders
2018
Non applicabile in quanto editoriale
Recensione di: Addio alla Natura, Gianfranco Marrone, Torino, Einaudi, 2011
2021
Review of the volume by Gianfranco Marrone: Farewell to nature published by Einaudi, 2011
Recensione a: La competenza esperta. Tipologie e trasmissione, Gianfranco Marrone et Tiziana Migliore (a cura di), Milan, Meltemi, 2021
2022
Review to: Expert competence. Types and transmission, Gianfranco Marrone and Tiziana Migliore (edited by), Milan, Meltemi
Cytomegalovirus inhibits the engraftment of donor bone marrow cells by downregulation of hemopoietin gene expression in recipient stroma
1998
ABSTRACT Cytomegalovirus (CMV) disease after bone marrow (BM) transplantation is often associated with BM graft failure. There are two possible reasons for such a correlation. First, a poor hematopoietic reconstitution of unrelated etiology could promote the progression of CMV infection by the lack of immune control. Alternatively, CMV infection could interfere with the engraftment of donor BM cells in recipient BM stroma. Evidence for a causative role of CMV in BM aplasia came from studies in long-term BM cultures and from the murine in vivo model of CMV-induced aplastic anemia. A deficiency in the expression of essential stromal hemopoietins, such as stem cell factor (SCF), has indicated …
Can bone marrow-derived multipotent adult progenitor cells regenerate infarcted myocardium?
2006
Objectives: To assess the functional effects of multipotent adult progenitor cells (MAPCs) transplanted in a rat model of chronic myocardial infarction. Methods: Forty-four rats underwent coronary ligation and, 14 days later, were randomly allocated to receive in-scar injections (5×106 cells/150 μL) of green fluorescent protein (eGFP)-transduced allogeneic MAPCs ( n =25) or culture medium (controls, n =19). Nine of the MAPC-treated hearts were employed for functional studies while the remaining 16 received cells co-labeled with Resovist™ and were only used for serial histological assessments. Left ventricular (LV) function was assessed echocardiographically before transplantation and 1 mont…
Die Entwicklung der Myelofibrose bei der "präfibrotischen"cIMF
2002
Zusammenfassung Wegen des erst kurzlich mit Erscheinen der neuen WHO-Klassifikation der chronischen myeloproliferativen Erkrankungen (CMPE) aufgegebenen Festhaltens an einer Knochenmarksfibrose als wesentliches Merkmal der chronischen idiopathischen Myelofibrose (cIMF) sind Verlaufsuntersuchungen zu der Entwicklung einer Myelofibrose (MF) bei dieser Entitat nur von fibrotischen Stadien mit widerspruchlichen Ergebnissen bekannt. Deshalb wurde eine retrospektive Studie an Verlaufsbiopsien von 38 Patienten mit cIMF ohne initiale Fibrose mit der Frage nach der Haufigkeit, der Geschwindigkeit sowie dem Ausmas der Entwicklung einer MF durchgefuhrt. Unabhangig von einer Chemotherapie fanden wir ei…
Chromosomenuntersuchungen aus Lymphocyten und Knochenmark von Psoriasis-Kranken nach Langzeitbehandlung mit Methotrexat
1970
4 Psoriasis-Patienten, 3 davon mit zuruckliegender Arsenexposition, hatten Gesamtmengen zwischen 570 und 2735 mg Methotrexat erhalten. Bei diesen Patienten wurden Chromosomendarstellungen aus dem Knochenmark und aus Lymphocytenkulturen durchgefuhrt. Im Knochenmark (ohne Kultur in vitro) fanden sich keine eindeutigen Aberrationen, wahrend in den Lymphocyten in 2 Fallen gehauft (24%) ein Chromosom regellos fehlte, und bei einem Patienten einzelne Bruche zu finden waren. Soweit aus diesen Beobachtungen in Verbindung mit den Daten der Literatur Schlusse gezogen werden durfen, werden sie bezuglich der Chromosomenmutationen diskutiert.
Moraltheologische Probleme der pluralistischen Gesellschaft nach Amoris laetitia am Beispiel von Oberschlesien
2017
Posynodalna adhortacja apostolska o miłości w rodzinie Amoris laetitia jest owocem i inspiracją do pogłębionej refleksji na temat złożonych problemów życia małżeńskiego i rodzinnego. W teologii refleksja ta powinna być wierna tradycji Kościoła, ale zarazem mocno związana z rzeczywistością. Oznacza to jedność nauczania i działania w zakresie rozumienia współczesnych problemów małżeństwa i rodziny oraz poszukiwania konkretnych rozwiązań duszpasterskich w tym względzie, co nie przeszkadza różnorodności sposobów interpretacji pewnych aspektów nauczania lub niektórych wynikających z niego konsekwencji. Z racji różnorodności tradycji i wyzwań w poszczególnych krajach i regionach, papież Francisze…
Lower secondary school pupils’ written descriptions of their experiences with bullying and the tendency to seek help
2021
The purpose of this study was to examine lower secondary school students’ (n = 223) descriptions of bullying and their experiences with the phenomenon. Students at three schools in Norway completed a survey containing open-ended questions. We employed a mixed-methods analytical approach in which responses were coded thematically and then quantified. Findings indicate that students viewed bullying in a manner consistent with prevalent definitions in the literature. However, they were often unsure whether social conflicts they had experienced would be considered bullying. School was clearly featured as the primary arena for bullying, although bullying in free-time activities and on social med…
Contact Sensitizers Specifically Increase MHC Class II Expression on Murine Immature Dendritic Cells
2000
Contact sensitivity is a T-cell-mediated immune disease that can occur when low-molecular-weight chemicals penetrate the skin. In vivo topical application of chemical sensitizers results in morphological modification of Langerhans cells (LC). Moreover, within 18 h, LC increase their major histocompatibility complex (MHC) class II antigens expression and migrate to lymph nodes where they present the sensitizer to T lymphocytes. We wanted to determine if such an effect could also be observed in vitro. However, because of the high genetic diversity encountered in humans, assays were performed with dendritic cells (DC) obtained from a Balb/c mouse strain. The capacity of a strong sensitizer, DN…