Search results for "Marr"
showing 10 items of 776 documents
The Role of Erythropoietin in Neuroprotection: Therapeutic Perspectives
2007
Nervous system diseases are very complex conditions comprising a large variety of local and systemic responses. Several therapeutic agents interfering with all or in part the biochemical steps that ultimately cause neuronal death have been demonstrated to be neuroprotective in preclinical models. However, all the agents so far investigated have inexorably failed in the phase III trials carried out. A large body of evidence suggests that the hormone erythropoietin (EPO), besides its well-known hematopoietic action, exerts beneficial effects in the central nervous system. EPO's effect has been assessed in several experimental models of brain and spinal cord injury thus becoming a serious cand…
Pathogenesis of circulatory reactions triggered by nervous reflexes during the implantation of bone cements.
1983
Circulatory and respiratory reactions during the implantation of joint endoprostheses have been observed for years. The components of the bone cements used for anchoring (methyl methacrylate monomer) or the outpour of bone marrow substances from the affected bone marrow cavity are thought to be chiefly responsible for these effects. However, our previous investigations demonstrated unambiguously that reactions of this type can be attributed to direct nervous-reflex mechanisms triggered by the pressure rise in the medullary canal, and that, in addition, bone marrow embolism plays a part in serious circulatory incidents. The investigations on which the present paper is based have confirmed th…
Electronmicroscopical Contrast by Palladium Chloride
1986
Thin sections of glutaraldehyde-fixed, epoxy resin-embedded bone marrow from rats were treated with 2% palladium chloride in 2% concentrated HCl. This procedure was found to induce high electron density in chromatin from all cell types and in cytoplasmic granules of neutrophils and eosinophils. In the latter, the crystalline body showed more contrast than the matrix.
From Missionary to Military Discourse: Economic Expansion and Rhetorical Shifting in the Nineteenth Century Adventure Story
2010
The essay aims at establishing the nature of the relationship between the development of the 19th century adventure story, the systematization of colonial enterprise and rise of imperialism and the construction of the concept of Britishness intended as a superior and missionary identity category. The analysis of Marryat’s Masterman Ready (1842), Ballantyne’s Coral Island (1857), Stevenson’s Treasure Island (1882) and Haggard’s King Solomon’s Mines (1885) will show how the rhetorical pattern of the 19th century adventure story, with particular reference to space and characters, goes through transformations in accordance with the economic transitions the system undergoes shifting from mission…
Tradizioni carnevalesche a Mezzojuso: dal Mastro di Campo al rogo del Nannu
2023
Il Mastro di Campo di Mezzojuso è una performance carnevalesca tradizionale che presenta un articolato simbolismo rituale riconducibile al pattern delle cerimonie di capodanno. In particolare si osservano il tema della ierogamia e della lotta rituale come elementi di promozione della fecondità. Ambedue i simboli rituali, la rappresentazione di una danza o di uno scontro armato, con l'eventuale coinvolgimento degli astanti e la celebrazione di un matrimonio, correlati o disgiunti, sono, come è noto, costitutivi ab antico delle cerimonie di capodanno, segnatamente di quelle primaverili. Altri rituali carnevaleschi europei hanno una simile articolazione. Il saggio presenta una serie di esempi …
"Wstępuje do świętego związku małżeńskiego" : śluby katolików w parafii oleskiej w latach 1819-1829
2022
The study takes up the subject of the history of the Catholic community living in the town of Olesno and the surrounding villages, belonging to the Olesno parish. Thanks to the marriage records in Polish language from 1819-1829, preserved in the National Archives in Opole, it is possible to present using statistical methods: how many weddings took place in the parish in particular months of the year, what day of the week was most often chosen for a wedding, what was the marital status of the newlyweds, their age at the time of marriage, along with their social and geographical origin. On the basis of the resulting data, it can be concluded that Olesno in the previously mentioned years was a…
Rituximab in vivo purging is safe and effective in combination with CD34-positive selected autologous stem cell transplantation for salvage therapy i…
2002
The purpose of this study was to evaluate feasibility and efficacy of Rituximab included into a sequential salvage protocol for CD20(+) B-NHL in relapse or induction failure. Twenty-seven patients with CD20(+) B-NHL in relapse or induction failure received Rituximab combined with DexaBEAM (R-DexaBEAM) for stem cell mobilization. Additional ex vivo selection of CD34-positive cells was performed using the CliniMacs device. Two doses of Rituximab were included in the high-dose therapy regimen (HDT). R-DexaBEAM was well tolerated and 26 of 27 patients mobilized sufficient numbers of CD34(+) blood stem cells. Application of R-DexaBEAM resulted in significant depletion of peripheral B cells. No t…
Effect of granulocyte-macrophage colony-stimulating factor on neutropenia and related morbidity induced by myelotoxic chemotherapy.
1990
Abstract purpose: A phase Ib/II clinical study was undertaken to assess the efficacy of recombinant human (rh) granulocyte-macrophage colony-stimulating (GM-CSF) factor in attenuating neutropenia and associated morbidity caused by high-dose anticancer chemotherapy administered in the presence or absence of autologous bone marrow support. patients and methods: Twenty-two patients with various solid tumors and lymphoid neoplasias were treated with a single daily subcutaneous dose of rh GM-CSF (250/μg/m 2 ) 48 hours after receiving a second cycle of highly myelotoxic chemotherapy for a period of 10 days. Within-subject comparisons on neutropenia-related clinical and laboratory variables were m…
Chromosomal abnormalities in women with breast cancer after autologous stem cell transplantation are infrequent and may not predict development of th…
2000
We determined prospectively the incidence of chromosomal abnormalities in patients with high-risk breast cancer (HRBC) after high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT), and correlated the cytogenetic abnormalities with the development of post-transplant myelodysplastic syndrome or acute myeloid leukemia (MDS/AML). From 1990 to 1999, 229 women with HRBC underwent ASCT. Cytogenetic analysis of bone marrow (BM) cells was performed 12–59 months after ASCT in 60 consecutive women uniformly treated with six courses of FAC/FEC followed by HDCT and ASCT. With a median follow-up of 36 months after ASCT, there were no cases of MDS/AML among the 229 patients. In the …
Single nucleotide polymorphism array karyotyping: A diagnostic and prognostic tool in myelodysplastic syndromes with unsuccessful conventional cytoge…
2013
Cytogenetic aberrations identified by metaphase cytogenetics (MC) have diagnostic, prognostic, and therapeutic implications in myelodysplastic syndromes (MDS). However, in some MDS patients MC study is unsuccesful. Single nucleotide polymorphism array (SNP-A) based karyotyping could be helpful in these cases. We performed SNP-A in 62 samples from bone marrow or peripheral blood of primary MDS with an unsuccessful MC study. SNP-A analysis enabled the detection of aberrations in 31 (50%) patients. We used the copy number alteration information to apply the International Prognostic Scoring System (IPSS) and we observed differences in survival between the low/intermediate-1 and intermediate-2/h…