Search results for "Matrix"
showing 10 items of 3205 documents
Type-II transmembrane prolyl dipeptidases and matrix metalloproteinases in membrane vesicles of active endothelial cells.
2006
Conclusions: Endothelia cells in sparse culture are migratory and increase the production of gelatinases of serine- and metallo-classes in membrane vesicles. Collectively, proteases associated with membrane vesicles degrade extracellular matrix components including type-I and type-IV collagens, laminin and fibronectin. Inhibitor studies suggest the existence of small gelatinases that were derived from these serine- and metallo-proteases. Thus, further studies are warranted to demonstrate the cooperative action of metallo- and serine proteases on cell surfaces and in extracellular vesicles during endothelial cell migration in 3D collagenous matrices, and potential proteolytic activation mech…
Robust fault detection design for unknown inputs Takagi-Sugeno models with parametric uncertainties and time-varying delays
2014
This paper deals with the design of robust fault detection system for Takagi-Sugeno (T-S) modes with parametric uncertainties and time-varying delay. An Unknown Input Observer (UIO) is designed such that the unknown inputs are thoroughly decoupled from residual signals while they show the maximum possible sensitivity to the faults and the minimum possible sensitivity to the external disturbances. Since the system under consideration is subjected to parametric uncertainties, the H ∞ model matching approach is used to design an optimal observer. Design procedure is given in terms of Linear Matrix Inequalities (LMIs). Finally, a numerical example is presented to show the effectiveness of the p…
Empirical Autotuning of Two-level Parallel Linear Algebra Routines on Large cc-NUMA Systems
2012
In large cc-NUMA systems the efficient use of the different levels of the memory hierarchy is not an easy task, and the performance of multithreading implementations of the libraries decreases when the number of cores used increases, so producing an important lost of efficiency. To alleviate this problem, routines with multilevel parallelism can be developed by combining OpenMP and BLAS parallelism. In that way, higher performance can be achieved, but it is necessary to develop some autotuning technique for the appropriate selection of the number of threads to use at each level. The selection can be made through theoretical models of the execution time or some installation methodology. This…
Taurine in the interphotoreceptor matrix
2014
TAURINE IN THE INTERPHOTORECEPTOR MATRIX Gueli Maria Concetta Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BioNEC), Università degli Studi di Palermo Taurine (Tau) is the most abundant amino compound free in the retina. It is concentrated in the photoreceptor inner segment, in the outer nuclear layer and in the synapses. The retina synthesizes and receives Tau from choroidal blood via the pigment epithelium (PE). The high content in the retina suggest the possibily of verifying whether it was present in the interphotoreceptor matrix (IPM), which occupies the subretinal space. In this study we have determined the Tau level in the IPM, separating it from other soluble ami…
Benchmarking of strength models for unidirectional composites under longitudinal tension
2018
© 2018 Elsevier Ltd Several modelling approaches are available in the literature to predict longitudinal tensile failure of fibre-reinforced polymers. However, a systematic, blind and unbiased comparison between the predictions from the different models and against experimental data has never been performed. This paper presents a benchmarking exercise performed for three different models from the literature: (i) an analytical hierarchical scaling law for composite fibre bundles, (ii) direct numerical simulations of composite fibre bundles, and (iii) a multiscale finite-element simulation method. The results show that there are significant discrepancies between the predictions of the differe…
Comparison of GTR, T-PRF and open-flap debridement in the treatment of intrabony defects with endo-perio lesions : a randomized controlled trial
2019
Background Titanium- prepared platelet rich fibrin (T-PRF) is an autologous hemo-component with a high concentration of platelets that also incorporates leukocytes, and growth factors into the dense fibrin matrix and can be used as a healing biomaterial. This study assesses the adjunctive use of T-PRF in intrabony defects (IBDs) with open flap debridement (OFD) in comparison with guided tissue regeneration (GTR) as a gold standard and OFD alone as a control. Material and Methods A total of 45 patients (15 per group) were randomized as either T-PRF (test group), GTR (test group), or OFD alone (control group) sites. Probing depth (PD), clinical attachment level (CAL), and IBD were recorded. T…
Early stages of test formation in larva of Ascidia malaca (Tunicata, Ascidiacea): ultrastructural and cytochemical investigations.
2003
Abstract The swimming larvae of ascidians are entirely covered by a hyalin coat called tunic, or test. This covering consists of two cuticular layers, C 1 and C 2 , which surround an inner compartment composed of an amorphous hyalin matrix with numerous fibrils dispersed inside. Data from the literature agree on the key role played by the cells of the larval ectodermic layer in the synthesis and secretion of larval test components. In the present article are reported ultrastructural and cytochemical investigations made during test formation in the swimming larva of Ascidia malaca . Besides confirming the role played by ectodermic cells during the early stages of test formation, the investig…
Cytotoxic phytochemicals from the crude extract of Tetrapleura tetraptera fruits towards multi-factorial drug resistant cancer cells.
2020
Abstract Ethnopharmacological relevance Tetrapleura tetraptera is an African medicinal spice used in traditional medicine to treat several ailments including cancer. Aim of the study The present study was designed to evaluate the cytotoxicity of the dichloromethane-methanol (1:1) extract of the fruits of Tetrapleura tetraptera (TTF) and its constituents: (3R, 4S)-3,4-dimethyloxetan-2-one (1), luteolin (2), stigmasterol (4), 3-O-[6′-O-undecanoyl-β-D-glucopyranosyl]stigmasterol (6), olean-12-en-3-β-O-D-glucopyranoside (7), 3-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosylurs-12-en-28-oic acid (8), 3-O-β-D-glucopyranosyl-(1 → 3)-β-D-glucopyranosyl-27-hydroxyolean-12-ene-28-oic acid (9), methyl…
DECORIN EFFECTS ON PROTEOMIC PROFILING OF BREAST CANCER CELLS: AN UPDATED STUDY
2015
The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells, among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect, the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules, the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin, belongs to the family of small leucine-rich proteoglycans (SLRP) and is involv…
MuLiMs-MCoMPAs: A Novel Multiplatform Framework to Compute Tensor Algebra-Based Three-Dimensional Protein Descriptors
2019
This report introduces the MuLiMs-MCoMPAs software (acronym for Multi-Linear Maps based on N-Metric and Contact Matrices of 3D Protein and Amino-acid weightings), designed to compute tensor-based 3D protein structural descriptors by applying two- and three-linear algebraic forms. Moreover, these descriptors contemplate generalizing components such as novel 3D protein structural representations, (dis)similarity metrics, and multimetrics to extract geometrical related information between two and three amino acids, weighting schemes based on amino acid properties, matrix normalization procedures that consider simple-stochastic and mutual probability transformations, topological and geometrical…