Search results for "Maturity"

The effects on offspring of premature parturition

2001

The time of parturition defines the length of the intrauterine period of fetal life, a requisite to achieve adequate adaptation to the external environment. Immaturity, a condition whose severity is inversely related to the length of pregnancy, is the main determinant of the increased morbidity and mortality associated with preterm birth. Despite great advances in medical technology and expertise, mainly after the introduction of the neonatal intensive care units, only one- to two-thirds of infants from the subsets with lower birthweight/gestational age reach survival at discharge. Distinct major neurological and sensorial sequelae, including cerebral palsy, retinopathy of prematurity, and …

Microvascular Sex- and Age- Dependent Phosphodiesterase Expression

2021

Objective: The cyclic nucleotide second messengers, cAMP and cGMP, are pivotal regulators of vascular functions; their cellular levels are tightly controlled by the cyclic nucleotide hydrolases, phosphodiesterases (PDE). Biologic sex and age are recognized as independent factors impacting the mechanisms mediating both vascular health and dysfunction. This study focused on microvessels isolated from male and female rats before (juvenile) and after (adult) sexual maturity under resting conditions. We tested the hypothesis that sexual dimorphism in microvascular PDE expression would be absent in juvenile rats, but would manifest in adult rats.Methods: Abdominal skeletal muscle arterioles and v…

The effect of gestational age and cervical length measurements in the prediction of spontaneous preterm birth in twin pregnancies : an individual pat…

2016

OBJECTIVE: To assess the effect of gestational age (GA) and cervical length (CL) measurements at transvaginal ultrasound (TVUS) in the prediction of preterm birth in twin pregnancy. DESIGN: Individual patient data (IPD) meta-analysis. SETTING: International multicentre study. POPULATION: Asymptomatic twin pregnancy. METHODS: MEDLINE and EMBASE searches were performed and IPD obtained from authors of relevant studies. Multinomial logistic regression analysis determined probabilities for birth at ≤28(+0) , 28(+1) to 32(+0) , 32(+1) to 36(+0) , and ≥36(+1) weeks as a function of GA at screening and CL measurements. MAIN OUTCOME MEASURES: Predicted probabilities for preterm birth at ≤28(+0) , 2…

Specific, concentration-dependent uptake of vitellin by the oocytes ofNereis virens (Annelida, Polychaeta) in vitro

1991

One purpose of this study was the development of methods for radioactive labeling and handling of the yolk protein of Nereis virens, another, the utilization of this tracer in nereid oocyte cultures to describe the kinetics and specificity of yolk protein uptake. Accumulation of labeled yolk protein by growing oocytes is linear over time, specific for yolk protein, and dependent on tracer concentration in the medium. Incorporation of yolk protein follows saturation kinetics which allows us to reproducibly determine the characteristics of this process. The apparent KM of ∼ 1 × 10−8 M indicates the high affinity of the transport system; the Vmax (160–400 pg protein/day × oocyte) reveals that …

Eye disease and mortality, cognition, disease, and modifiable risk factors: an umbrella review of meta-analyses of observational studies

2022

Globally, 2.2 billion people live with some form of vision impairment and/or eye disease. To date, most systematic reviews examining associations have focused on a single eye disease and there is no systematic evaluation of the relationships between eye diseases and diverse physical and mental health outcomes. Moreover, the strength and reliability of the literature is unclear. We performed an umbrella review of observational studies with meta analyses for any physical and/or mental comorbidities associated with eye disease. For each association, random-effects summary effect size, heterogeneity, small-study effect, excess significance bias and 95% prediction intervals were calculated, and …

Factors Predisposing to Hypertension in Subjects Formerly Born Preterm: Renal Impairment, Arterial Stiffness, Endothelial Dysfunction or 
Something E…

2020

: Subjects formerly born preterm subsequently develop arterial - particularly isolated systolic- hypertension more frequently than their peers born at term. : Numerous factors may influence this predisposition, including an incomplete nephrogenesis, implying the presence of kidneys with a reduced number of nephrons and consequent reduction in haematic filtration, increased sodium absorption and activation of renin-angiotensin-aldosterone system, increased arterial rigidity produced by an elastin deficiency previously observed in anatomic specimens of human immature aorta, and reduced endothelial nitric oxide excretion, due to high blood levels of ADMA, a strong direct inhibitor of nitric o…

Impact of Genetic and Cultural Factors on Extra-Virgin Olive Oil Composition

Oznaczenie wykonalności jako nowy element pozwu - wybrane zagadnienia

2019

Attitudes and related perceptions about product placement: a comparison of Finland, Italy and the United States

2015

The primary goal of our study is to explore cross-national differences in attitudes and perceptions about product placements, after investigating measurement invariance. Our cross-national focus includes three countries that have not been compared previously: Finland, Italy and the USA, which differ significantly in terms of the evolution/maturity of product placement markets, regulatory structures and cultural contexts. Motivated by earlier studies, we investigate the cross-national measurement invariance of scales to measure four research constructs related to the product placement domain (attitude toward credibility of advertising, attitude toward advertising-in-general, attitude toward …

Kokonaisarkkitehtuurin laadun ja kypsyystason yhteys

2017

Tässä opinnäytetyössä tarkastellaan, onko kokonaisarkkitehtuurin kypsyystasolla ja kokonaisarkkitehtuurituotteen laadulla keskinäistä yhteyttä. Tämän selvittämiseksi valittiin kirjallisuuslähteistä ne artikkelit, joissa kokonaisarkkitehtuurin laatua tutkitaan laatuattribuuttien (quality attributes) kautta. Näiden artikkeleiden perusteella muodostettiin kahdeksan laatuattribuuttia. Näiden laatuattribuuttien kuvauksia verrattiin kolmen kypsyysmallin (JHKA:n kypsyystasomalli, EAMM, DyAMM) kypsyystasokuvauksiin. Näin haluttiin selvittää, kuuluvatko laatuattribuutit tietyille kypsyystasoille. Tämän tarkastelun perusteella näyttää siltä, että kokonaisarkkitehtuurituotteen laadulla ja kypsyystasol…