The effect of gestational age and cervical length measurements in the prediction of spontaneous preterm birth in twin pregnancies : an individual patient level meta-analysis

6533b86dfe1ef96bd12ca928

RESEARCH PRODUCT

The effect of gestational age and cervical length measurements in the prediction of spontaneous preterm birth in twin pregnancies : an individual patient level meta-analysis

Liona C. Poon Liona C. Poon Kypros H. Nicolaides David A. Macintyre Ewoud Schuit Ben W.j. Mol T. G. Teoh Vicente Serra Arianne C. Lim Stefano Cacciatore Nathan S. Fox Phillip R. Bennett Alfredo Perales Frederik J.r. Hermans Ara Darzi Sophie Liem L Kindinger L Kindinger

subject

medicine.medical_specialty Population Gestational Age Cervix Uteri Review Research Support 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Pregnancy medicine Journal Article Humans 030212 general & internal medicine Non-U.S. Gov't education Twin Pregnancy Gynecology education.field_of_study Pregnancy 030219 obstetrics & reproductive medicine business.industry Obstetrics Research Support Non-U.S. Gov't prematurity Twin Obstetrics and Gynecology Gestational age preterm birth twin pregnancy medicine.disease Cervical Length Measurement Multicenter Study individual patient meta-analysis Premature birth Cervical Length Measurement Predictive value of tests Pregnancy Twin Gestation Premature Birth Female business Cervical length Meta-Analysis

description

OBJECTIVE: To assess the effect of gestational age (GA) and cervical length (CL) measurements at transvaginal ultrasound (TVUS) in the prediction of preterm birth in twin pregnancy. DESIGN: Individual patient data (IPD) meta-analysis. SETTING: International multicentre study. POPULATION: Asymptomatic twin pregnancy. METHODS: MEDLINE and EMBASE searches were performed and IPD obtained from authors of relevant studies. Multinomial logistic regression analysis determined probabilities for birth at ≤28(+0) , 28(+1) to 32(+0) , 32(+1) to 36(+0) , and ≥36(+1) weeks as a function of GA at screening and CL measurements. MAIN OUTCOME MEASURES: Predicted probabilities for preterm birth at ≤28(+0) , 28(+1) to 32(+0) , and 32(+1) to 36(+0) . RESULTS: A total of 6188 CL measurements were performed on 4409 twin pregnancies in 12 studies. Both GA at screening and CL had a significant and non-linear effect on GA at birth. The best prediction of birth at ≤28(+0) weeks was provided by screening at ≤18(+0) weeks (P 22(+0) weeks is most predictive of delivery at 28(+1) to 36(+0) weeks. In twins, we recommend CL screening in twins to commence from ≤18(+0) weeks. TWEETABLE ABSTRACT: An individual patient meta-analysis assessing gestation and CL in the prediction of preterm birth in twins.

year	journal	country	edition	language
2016-05-01

https://dspace.library.uu.nl/handle/1874/343511