Search results for "Maxim"
showing 10 items of 1236 documents
Los viajes de Maximiliano a España y Brasil: el largo camino hacia el imperio mexicano
1970
En mayo de 1864 Maximiliano de Austria llega a la costa mexicana en el que será su último viaje, que culminará con su ejecución tres años después. Mucho se ha escrito sobre las razones que le impulsaron a aceptar la corona de México, un país tan alejado en todos los sentidos de su entorno cultural, sin embargo, años antes Maximiliano había viajado a España y a Brasil (a España en dos ocasiones) y estas experiencias, si no determinantes, influyeron en gran medida en la decisión del Archiduque, que vio la oportunidad de hacer realidad un sueño que se gestó en su viaje a España y se afianzó durante su estancia en Brasil, como se puede extraer de sus memorias de viaje. In May of 1864, Maximilia…
Semantic Models and Translating
1994
Abstract: This paper examines the relevance of three semantic models for translation. Structural semantics, more specifically semantic feature analysis, has given rise to the maxim that we should translate "bundles of semantic features". Prototype semantics suggests that word-meanings have cores and fuzzy edges which are influenced by culture. For translation this means that we do not necessarily translate bundles of features but have to decide whether to focus on the core or the fuzzy edges of the meaning of a particular word. Scenes-and-frames semantics suggests that word meaning is influenced by context and the situation we are in. Word-meaning is thus not static but dynamic, and it is t…
Deterministic Linkage as a Preceding Filter for Other Record Linkage Methods
2015
Deterministic record linkage (RL) is frequently regarded as a rival to more sophisticated strategies like probabilistic RL. We investigate the effect of combining deterministic linkage with other linkage techniques. For this task, we use a simple deterministic linkage strategy as a preceding filter: a data pair is classified as ‘match' if all values of attributes considered agree exactly, otherwise as ‘nonmatch'. This strategy is separately combined with two probabilistic RL methods based on the Fellegi–Sunter model and with two classification tree methods (CART and Bagging). An empirical comparison was conducted on two real data sets. We used four different partitions into training data a…
Accounting for haplotype phase uncertainty in linkage disequilibrium estimation
2007
The characterization of linkage disequilibrium (LD) is applied in a variety of studies including the identification of molecular determinants of the local recombination rate, the migration and population history of populations, and the role of positive selection in adaptation. LD suffers from the phase uncertainty of the haplotypes used in its calculation, which reflects limitations of the algorithms used for haplotype estimation. We introduce a LD calculation method, which deals with phase uncertainty by weighting all possible haplotype pairs according to their estimated probabilities as evaluated by PHASE. In contrast to the expectation-maximization (EM) algorithm as implemented in the HA…
Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors.
2013
International audience; BACKGROUND: Lipids A, the lipophilic partial structure of lipopolysaccharides, induce regression of several tumor types in animal models. Rather than exerting direct cytotoxic effect, these compounds trigger the immune system which in turn stimulates secretion of cytokines, and activates the inducible nitric oxide synthase, as well as immune cell infiltration of tumors. OM-174 is an analogue of lipid A with dual action on toll-like receptors 2 and 4. In an experimental model of peritoneal carcinomatosis induced in BDIX rats by intraperitoneal injection of syngeneic PROb colon cancer cells, it induced a complete regression of tumors. The present phase I trial was cond…
HPLC-UV/Vis-APCI-MS/MS Determination of Major Carotenoids and Their Bioaccessibility from "Delica" (Cucurbita maxina) and "Violina" (Cucurbita moscha…
2018
Carotenoids are a widespread group of fat-soluble pigments, and their major nutritional importance comes from their pro-vitamin A activity and their antioxidant capacity. In this study, two different pumpkin cultivars (Cucurbita maxima, also named `Delica&rsquo
A Nonlinear Observer for Rotor Flux Estimation of Induction Motor Considering the Estimated Magnetization Characteristic
2017
This paper proposes a nonlinear observer for induction machine drives based on space-vector dynamic model of induction machine, expressed in state form, which presents the peculiarity of taking into consideration the magnetic saturation of the iron core. This observer is particularly suitable in order to obtain high accuracy in rotor flux estimation, in both amplitude and phase position, during working conditions characterized by varying flux, among which the most important are those during electrical losses minimization. A Lyapunov-based convergence analysis is proposed in order to suitably compute the numerical observer gain guaranteeing the convergence of the estimation error. The propos…
Molecular signaling in muscle is affected by the specificity of resistance exercise protocol
2010
Mammalian target of rapamycin and mitogen-activated protein kinase (MAPK) signaling pathways have been highlighted as important for muscle adaptations and thus, they may distinguish adaptations to different exercises. Typically, resistance exercise designed for muscle hypertrophy has moderate intensity (60-80% of one repetition maximum, 1 RM) while one prioritizing maximal strength with minor hypertrophy has a higher intensity (≥90% of 1 RM). Eight untrained men (28.4 ± 3.7 years) conducted two different bilateral leg press exercise protocols: hypertrophic (5 × 10 RM) and pure maximal strength (15 × 1 RM) in a counterbalanced, cross-over design with 1 week between exercises. Vastus laterali…
Bispecific T-Cell Engager (BiTE) Antibody Construct Blinatumomab for the Treatment of Patients With Relapsed/Refractory Non-Hodgkin Lymphoma : Final …
2016
Purpose Blinatumomab is a CD19/CD3 BiTE (bispecific T-cell engager) antibody construct for the treatment of Philadelphia chromosome–negative acute B-lymphoblastic leukemia. We evaluated blinatumomab in relapsed/refractory B-cell non-Hodgkin lymphoma (NHL). Patients and Methods This 3 + 3 design, phase I dose-escalation study determined adverse events and the maximum tolerated dose (MTD) of continuous intravenous infusion blinatumomab in patients with relapsed/refractory NHL. Blinatumomab was administered over 4 or 8 weeks at seven different dose levels (0.5 to 90 μg/m2/day). End points were incidence of adverse events, pharmacokinetics, pharmacodynamics, and overall response rate. Results B…
Neuronal nitric oxide synthase is involved in CB/TRPV1 signalling: Focus on control of hippocampal hyperexcitability
2017
Cannabinoids (CB), transient receptors potential vanilloid type 1 (TRPV1) and nitric oxide (NO) were found to be interlinked in regulating some neuronal functions such as membrane excitability and synaptic transmission. TRPV1 play a fundamental role since it represents a synaptic target for CB that triggers several downstream cellular pathways. In this regard, recent evidence report that TRPV1 could influence NO production by modulating neuronal NO synthase (nNOS) activity. In the present research, we pointed to manipulate nNOS function to assess its role on TRPV1 signalling in hyperexcitability conditions elicited in the dentate gyrus of hippocampal formation. The activation of TRPV1 recep…