Search results for "Measurement"
showing 10 items of 2918 documents
Differential changes in purine nucleotides after Doxorubicin treatment of human cancer cells in vitro
2002
The present investigation was performed to elucidate the role of purine nucleotides as potential indicators of chemosensitivity of malignant tumors. Drug-sensitive (s) and -resistant (r) tumor cell lines grown as monolayers (s: T47D, MCF-7 wild-type; r: NCI/ADR-RES, MCF-7/MDR) or as multicellular spheroids (T47D; NCI/ADR-RES) were exposed to 0.1, 1.0, and 10.0 microM Doxorubicin for up to 24 h. Purine nucleotides were assayed using HPLC and with some selected spheroids using imaging bioluminescence. The data show that in the time frame of the experiments reproducible and statistically significant changes in the nucleotides only occur at the highest drug concentration investigated. Under the…
Continuous Analysis of Running Mechanics by Means of an Integrated INS/GPS Device
2019
This paper describes a single body-mounted sensor that integrates accelerometers, gyroscopes, compasses, barometers, a GPS receiver, and a methodology to process the data for biomechanical studies. The sensor and its data processing system can accurately compute the speed, acceleration, angular velocity, and angular orientation at an output rate of 400 Hz and has the ability to collect large volumes of ecologically-valid data. The system also segments steps and computes metrics for each step. We analyzed the sensitivity of these metrics to changing the start time of the gait cycle. Along with traditional metrics, such as cadence, speed, step length, and vertical oscillation, this system est…
Experimental validation of a quaternion-based attitude estimation with direct input to a quadcopter control system
2013
This paper presents a method to calculate the attitude quaternion of a quadcopter with few calculations. The quaternion calculation is based on accelerometers and gyroscopes from an Inertial Measurement Unit (IMU). The quaternion from the accelerometer is calculated as the shortest rotation arc from the gravity vector in the navigation frame. The quaternion from the gyroscope is calculated based on equations of the quaternion derivative. A complementary filter is combining the two quaternions with a componentwise comparison. The attitude estimation is calculated without any trigonometric functions. The quaternion is directly used as an input to the attitude controller. The attitude controll…
Cross-cultural adaptation and test-retest reliability of the spanish ROWAN foot pain assessment questionnaire (ROFPAQ-S)
2020
Background The ROWAN Foot Pain Assessment Questionnaire (ROFPAQ) may be considered as a self-reported health questionnaire with 45 items to measure foot health problems such as foot pain. To date, the ROFPAQ has only been validated into an English-language version. Objectives Therefore this study aim was to perform the cross-cultural adaptation and test-retest reliability of the Spanish ROFPAQ version (ROFPAQ-S). Study design A cross-sectional descriptive study. Settings Podiatry and physiotherapy clinical centers. Methods The recommended forward/backward translation protocol was applied for the procedure of translation and cross-cultural adaptation from United Kingdom to Spain. Results An …
Effect of foot health and quality of life in patients with Parkinson disease: A prospective case-control investigation.
2022
Financiado para publicación en acceso aberto: Universidade da Coruña/CISUG [Abstract] Background Parkinson's disease (PD) is a common neurodegenerative disorder, characterised by the presence of motor disturbances. Therefore, it can be related to musculoskeletal and orthopaedic problems, particularly in the foot status, that are linked to a negative effect on overall health, mobility and social function. Objective The aim was to analyse the impact of foot health and quality of life in patients with Parkinson's disease and people without Parkinson's disease, with normalised reference scores, in the light of the values recorded with regard to foot health status and overall health. Material an…
Validation of the Italian version of the abbreviated expanded prostate Cancer index composite (EPIC-26) in men with prostate Cancer
2019
Abstract Background This study aims to validate and evaluate the psychometric properties and reliability of the Italian version of the Expanded Prostate Cancer Index Composite – Short Form (EPIC-26), a measure of quality of life (QoL) for prostate cancer patients. Methods Two hundred and eighty-four prostate cancer patients completed the Italian version of the EPIC-26 questionnaire at 45 days (T1) and 3 months (T2) after robot-assisted radical prostatectomy (RARP). Psychometric properties were evaluated using structural equation modeling: the goodness of fit of the correlated five-factor model (CFFM) for the EPIC-26 was assessed using the confirmatory factor analysis (CFA), while longitudin…
Randomized controlled trial of postoperative exercise rehabilitation program after lumbar spine fusion: study protocol
2012
Abstract Background Lumbar spine fusion (LSF) effectively decreases pain and disability in specific spinal disorders; however, the disability rate following surgery remains high. This, combined with the fact that in Western countries the number of LSF surgeries is increasing rapidly it is important to develop rehabilitation interventions that improve outcomes. Methods/design In the present RCT-study we aim to assess the effectiveness of a combined back-specific and aerobic exercise intervention for patients after LSF surgery. One hundred patients will be randomly allocated to a 12-month exercise intervention arm or a usual care arm. The exercise intervention will start three months after su…
Polymer brushes on flat and curved surfaces: How computer simulations can help to test theories and to interpret experiments
2012
Theoretical descriptions of static properties of polymer brushes are reviewed, with an emphasis on monodisperse macromolecules grafted to planar, cylindrical, or spherical substrates. Blob concepts and resulting scaling relations are outlined, and various versions of the self-consistent field theory are summarized: the classical approximation and the strong stretching limit, as well as the lattice formulation. The physical justification of various inherent assumptions is discussed, and computer simulation results addressing the test of the validity of these approximations are reviewed. Also, alternative theories, such as the single chain mean field theory and the density functional theory, …
Monte Carlo simulations of polymer dynamics: Recent advances
1997
A brief review is given of applications of Monte Carlo simulations to study the dynamical properties of coarse-grained models of polymer melts, emphasizing the crossover from the Rouse model toward reptation, and the glass transition. The extent to which Monte Carlo algorithms can mimic the actual chain dynamics is critically examined, and the need for the use of coarse-grained rather than fully atomistic models for such simulations is explained. It is shown that various lattice and continuum models yield qualitatively similar results, and the behavior agrees with the findings of corresponding molecular dynamics simulations and experiments, where available. It is argued that these simulatio…
Understanding Civic Engagement on Social Media Based on Users’ Motivation to Contribute
2021
Social media offer various opportunities for civic engagement by, e.g., liking, sharing, or posting relevant content. Users’ motivation to contribute to relevant topics is quite divers and can stem from an intrinsic motivation to do good or external incentives such as being recognised and rewarded by other users. In our study, we adopt self-determination theory, which defines motivation as broad continuum ranging from intrinsic motivation to external regulation. We conducted a quantitative survey with 667 Facebook users to identify how the different kinds of motivation impact the users’ behaviour in terms of reading, liking, sharing, commenting, and posting topics relevant to civic engageme…